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Ltb
Gene Detail
 Symbol
Name
ID
Ltb
lymphotoxin B
MGI:104796
Synonyms LTbeta, lymphotoxin beta, p33, Tnfc, Tnfsf3
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr17:35194439-35196320 bp, + strand
From VEGA annotation of GRCm38

  1882 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1752  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Ltb

Human
homologs
Human Homolog LTB, lymphotoxin beta (TNF superfamily, member 3)
NCBI Gene ID 4050
neXtProt AC  NX_Q06643
Human Synonyms  p33, TNFC, TNFSF3
Human Chr (Location)  6p21.3; chr6:31580558-31582425 (-)  GRCh38
Alleles
and
phenotypes
All alleles(28) : Gene trapped(17) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations lack peripheral lymph nodes, Peyer's patches, splenic germinal centers and follicular dendritic cells. Mutants exhibit lymphocytosis in the circulation and peritoneal cavity with infiltrations of the lung and liver.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process gene expression, immune response, ...
Component extracellular space, integral component of membrane, ...
Function cytokine activity, tumor necrosis factor receptor binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (12)    Tissues (4)    Images (1)
Theiler Stages: 17, 25, 28
Assay TypeResults
RT-PCR 12
cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(43) Genomic(17) cDNA(23) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037195 (Evidence)
Ensembl Gene ModelENSMUSG00000024399 (Evidence)
Entrez Gene16994 (Evidence)
UniGene1715
DFCITC1600262, TC1625787
DoTSDT.101127043, DT.531106
NIA Mouse Gene IndexU017895
Consensus CDS ProjectCCDS28690.1
International Mouse Knockout Project StatusLtb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037195 VEGA Gene Model | MGI Sequence Detail 1882 C57BL/6J ±  kb
transcript OTTMUST00000095885 VEGA | MGI Sequence Detail 1160 Not Applicable 
polypeptide OTTMUSP00000053527 VEGA | MGI Sequence Detail 306 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006052 Tumour necrosis factor
InterPro IPR006053 Tumour necrosis factor alpha/beta/c
InterPro IPR002961 Tumour necrosis factor c/lymphotoxin-beta
InterPro IPR021184 Tumour necrosis factor, conserved site
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000002205 lymphotoxin-beta
References (Earliest) J:30783 Shacks SJ, et al., Studies on in vitro models of cellular immunity: the role of T and B cells in the secretion of lymphotoxin. Cell Immunol. 1973 May;7(2):313-21
(Latest) J:206381 Yang CY, et al., Trapping of naive lymphocytes triggers rapid growth and remodeling of the fibroblast network in reactive murine lymph nodes. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E109-18
All references(148)
Other
accession IDs
MGD-MRK-16192, MGD-MRK-28088, MGI:2146913

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory