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Ltb
Gene Detail
Symbol

Name
ID
Ltb
lymphotoxin B
MGI:104796
Synonyms
LTbeta, lymphotoxin beta, p33, Tnfc, Tnfsf3
Feature Type
protein coding gene
Genetic Map
Chromosome 17
18.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr17:35194439-35196320 bp, + strand
From VEGA annotation of GRCm38

  1882 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1752  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: LTB
Gene Tree: Ltb

Human
homologs
LTB, lymphotoxin beta (TNF superfamily, member 3)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4050
neXtProt AC: NX_Q06643

Human Synonyms: p33, TNFC, TNFSF3

Human Chr (Location): 6p21.3; chr6:31580558-31582425 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(17) Targeted(12) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations lack peripheral lymph nodes, Peyer's patches, splenic germinal centers and follicular dendritic cells. Mutants exhibit lymphocytosis in the circulation and peritoneal cavity with infiltrations of the lung and liver.
 
Interactions
Ltb interacts with 17 markers (Mir10a, Mir155, Mir181a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process gene expression, immune response, ...
Component extracellular space, integral component of membrane, ...
Function cytokine activity, tumor necrosis factor receptor binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (12)    Tissues (4)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 12
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ltb    NEW 
Molecular
reagents
All nucleic(43) Genomic(17) cDNA(23) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037195 (Evidence)
Ensembl Gene Model ENSMUSG00000024399 (Evidence)
Entrez Gene 16994 (Evidence)
UniGene 1715
DFCI TC1600262, TC1625787
DoTS DT.531106, DT.101127043
NIA Mouse Gene Index U017895
Consensus CDS Project CCDS28690.1
International Mouse Phenotyping Consortium Status Ltb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037195 VEGA Gene Model | MGI Sequence Detail 1882 C57BL/6J ±  kb
transcript OTTMUST00000095885 VEGA | MGI Sequence Detail 1160 Not Applicable 
polypeptide OTTMUSP00000053527 VEGA | MGI Sequence Detail 306 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006052 Tumour necrosis factor
InterPro IPR006053 Tumour necrosis factor alpha/beta/c
InterPro IPR002961 Tumour necrosis factor c/lymphotoxin-beta
InterPro IPR021184 Tumour necrosis factor, conserved site
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000002205 lymphotoxin-beta
References
(Earliest) J:30783 Shacks SJ, et al., Studies on in vitro models of cellular immunity: the role of T and B cells in the secretion of lymphotoxin. Cell Immunol. 1973 May;7(2):313-21
(Latest) J:220682 Zorca CE, et al., Myosin VI regulates gene pairing and transcriptional pause release in T cells. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1587-93
All references(150)
Other
accession IDs
MGD-MRK-16192, MGD-MRK-28088, MGI:2146913

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory