About   Help   FAQ
Ltb Gene Detail
Summary
  • Symbol
    Ltb
  • Name
    lymphotoxin B
  • Synonyms
    LTbeta, lymphotoxin beta, p33, Tnfc, Tnfsf3
  • Feature Type
    protein coding gene
  • IDs
    MGI:104796
    NCBI Gene: 16994
  • Gene Overview
    MyGene.info: LTB
Location & Maps
more
  • Sequence Map
    Chr17:35194439-35196320 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1882 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.59 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    LTB, lymphotoxin beta
  • Vertebrate Orthologs
    7
  • Human Ortholog
    LTB, lymphotoxin beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p33, TNFC, TNFSF3, TNLG1C
  • Links
    NCBI Gene ID: 4050
    neXtProt AC: NX_Q06643

  • Chr Location
    6p21.3; chr6:31580558-31582425 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 6 alleles in 7 genetic backgrounds
    15 phenotypes from multigenic genotypes
    99 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations lack peripheral lymph nodes, Peyer's patches, splenic germinal centers and follicular dendritic cells. Mutants exhibit lymphocytosis in the circulation and peritoneal cavity with infiltrations of the lung and liver.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037195 VEGA Gene Model | MGI Sequence Detail 1882 C57BL/6J ±  kb
transcript OTTMUST00000095885 VEGA | MGI Sequence Detail 1160 Not Applicable  
polypeptide OTTMUSP00000053527 VEGA | MGI Sequence Detail 306 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 43
    Genomic 17
    cDNA 23
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16192, MGD-MRK-28088, MGI:2146913
References
more
  • Summaries
    All 152
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 99
  • Earliest
    J:30783 Shacks SJ, et al., Studies on in vitro models of cellular immunity: the role of T and B cells in the secretion of lymphotoxin. Cell Immunol. 1973 May;7(2):313-21
  • Latest
    J:229773 Kumar V, et al., A dendritic-cell-stromal axis maintains immune responses in lymph nodes. Immunity. 2015 Apr 21;42(4):719-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/13/2016
MGI 6.05
The Jackson Laboratory