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Smyd1
Gene Detail
Symbol

Name
ID
Smyd1
SET and MYND domain containing 1
MGI:104790
Synonyms
4632404M21Rik, Bop
Feature Type
protein coding gene
Genetic Map
Chromosome 6
32.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:71213940-71322233 bp, - strand
From VEGA annotation of GRCm38

  108294 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7645  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: protein methyltransferase, HSKM-B type
Gene Tree: Smyd1

Human
homologs
Human Homolog SMYD1, SET and MYND domain containing 1
NCBI Gene ID 150572
neXtProt AC  NX_Q8NB12
Human Synonyms  BOP, KMT3D, ZMYND18, ZMYND22
Human Chr (Location)  2p11.2; chr2:88067780-88113384 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(74) : Gene trapped(71) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryonic lethality at E10.5. Mutant embryos exhibit an enlarged heart and developmental abnormalities of the right ventricle.
 
Interactions
Smyd1 interacts with 221 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process chromatin remodeling, heart development, ...
Component cytoplasm, nucleus
Function DNA binding, histone-lysine N-methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (27)    Tissues (22)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 15
Northern blot 10
RT-PCR 2
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(23) Primer pair(1) Other(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000022727 (Evidence)
Ensembl Gene ModelENSMUSG00000055027 (Evidence)
Entrez Gene12180 (Evidence)
DFCITC1598061, TC1594332, TC1593180, TC1581269
DoTSDT.101368695, DT.87058790, DT.55193490, DT.55158145
NIA Mouse Gene IndexU027453
EC2.1.1.43
PDB3N71
Consensus CDS ProjectCCDS20227.2, CCDS51805.1
International Mouse Knockout Project StatusSmyd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022727 VEGA Gene Model | MGI Sequence Detail 108294 C57BL/6J ±  kb
transcript OTTMUST00000054509 VEGA | MGI Sequence Detail 3361 Not Applicable 
polypeptide OTTMUSP00000026032 VEGA | MGI Sequence Detail 490 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(4) UniProt(11)
Polymorphisms
SNPs within 2kb(716 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001214 SET domain
InterPro IPR002893 Zinc finger, MYND-type
Protein Ontology PR:000015306 histone-lysine N-methyltransferase SMYD1
References
(Earliest) J:29731 Hwang I, et al., Bop: a new T-cell-restricted gene located upstream of and opposite to mouse CD8b. Immunogenetics. 1995;42(5):353-61
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(49)
Other
accession IDs
MGD-MRK-28082, MGI:2141746

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory