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Kcnj6
Gene Detail
 Symbol
Name
ID
Kcnj6
potassium inwardly-rectifying channel, subfamily J, member 6
MGI:104781
Synonyms GIRK2, KCNJ7, Kir3.2
Feature Type protein coding gene
Genetic Map
Chromosome 16
55.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr16:94749266-94997696 bp, - strand
From Ensembl annotation of GRCm38

  248431 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1688  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj6

Human
homologs
Human Homolog KCNJ6, potassium inwardly-rectifying channel, subfamily J, member 6
NCBI Gene ID 3763
neXtProt AC  NX_P48051
Human Synonyms  BIR1, GIRK2, GIRK-2, hiGIRK2, KATP2, KATP-2, KCNJ7, KIR3.2
Human Chr (Location)  21q22.1; chr21:37624476-37916438 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Spontaneous(1) Targeted(3)
Genomic Mutations involving Kcnj6 (2)
Incidental mutations (data from Mutagenetix , APF )
 
A spontaneous mutation exhibits small size, ataxia, hypotonia, high periweaning mortality, Purkinje cell defects, and male sterility. Homozygotes for a targeted null mutation exhibit increased susceptibility to spontaneous and drug-induced seizures.
 
Phenotype Images(1)
Interactions
Kcnj6 interacts with 307 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component axon, cell surface, ...
Function G-protein activated inward rectifier potassium channel activity, G-protein alpha-subunit binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (346)    Tissues (183)    Images (19)
Theiler Stages: 13, 15, 16, 17, 20, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 271
RT-PCR 75
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) Genomic(11) cDNA(19) Primer pair(7)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000043301 (Evidence)
Entrez Gene16522 (Evidence)
UniGene328720
DFCITC1586450, TC1589017, TC1591533, TC1591775, TC1594041
DoTSDT.101265821, DT.40167239, DT.55225529, DT.87034086, DT.87047690, DT.91279633, DT.91338206
NIA Mouse Gene IndexU111595
PDB2E4F, 3AGW, 3ATA, 3ATB, 3ATD, 3ATE, 3ATF, 3AUW, 3SYA, 3SYC, 3SYO, 3SYP, 3SYQ, 3VSQ, 4KFM, 3AT8, 3AT9
Consensus CDS ProjectCCDS37408.1, CCDS37409.1, CCDS49921.1
International Mouse Knockout Project StatusKcnj6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043301 Ensembl Gene Model | MGI Sequence Detail 248431 C57BL/6J ±  kb
transcript ENSMUST00000099508 Ensembl | MGI Sequence Detail 3086 Not Applicable 
polypeptide ENSMUSP00000097108 Ensembl | MGI Sequence Detail 425 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(10) UniProt(5)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(1951 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR016449 Potassium channel, inwardly rectifying, Kir
InterPro IPR003275 Potassium channel, inwardly rectifying, Kir3.2
InterPro IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology PR:000002003 G protein-activated inward rectifier potassium channel 2
References (Earliest) J:13422 Lane PW, Weaver, wv. Mouse News Lett. 1964;30:32
(Latest) J:205383 Salti A, et al., Expression of early developmental markers predicts the efficiency of embryonic stem cell differentiation into midbrain dopaminergic neurons. Stem Cells Dev. 2013 Feb 1;22(3):397-411
All references(291)
Other
accession IDs
MGD-MRK-15467, MGD-MRK-28073

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory