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Kcnj6 Gene Detail
Summary
  • Symbol
    Kcnj6
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 6
  • Synonyms
    GIRK2, KCNJ7, Kir3.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104781
    NCBI Gene: 16522
  • Gene Overview
    MyGene.info: KCNJ6
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:94748683-94997696 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 55.44 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1938 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104781
protein coding gene Chr16:94748683-94997696 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023074
protein coding gene Chr16:96008390-96283870 (-)
A/J MGP_AJ_G0023042
protein coding gene Chr16:91487985-91739070 (-)
AKR/J MGP_AKRJ_G0023012
protein coding gene Chr16:94292652-94543844 (-)
BALB/cJ MGP_BALBcJ_G0023044
protein coding gene Chr16:92028903-92280147 (-)
C3H/HeJ MGP_C3HHeJ_G0022805
protein coding gene Chr16:94807985-95072857 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023491
protein coding gene Chr16:99074325-99343573 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020993
protein coding gene Chr16:89341486-89595901 (-)
CAST/EiJ MGP_CASTEiJ_G0022324
protein coding gene Chr16:95572715-95845884 (-)
CBA/J MGP_CBAJ_G0022774
protein coding gene Chr16:103333111-103595510 (-)
DBA/2J MGP_DBA2J_G0022908
protein coding gene Chr16:91378776-91628046 (-)
FVB/NJ MGP_FVBNJ_G0022882
protein coding gene Chr16:90538814-90792971 (-)
LP/J MGP_LPJ_G0022978
protein coding gene Chr16:95665543-95923655 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022903
protein coding gene Chr16:107656108-107927196 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023509
protein coding gene Chr16:94818318-95081022 (-)
PWK/PhJ MGP_PWKPhJ_G0022069
protein coding gene Chr16:91644130-91901069 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021899
protein coding gene Chr16:94357097-94621826 (-)
WSB/EiJ MGP_WSBEiJ_G0022375
protein coding gene Chr16:95079355-95347889 (-)



Homology
more
  • Human Ortholog
    KCNJ6, potassium voltage-gated channel subfamily J member 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNJ6, potassium voltage-gated channel subfamily J member 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BIR1, GIRK2, GIRK-2, hiGIRK2, KATP2, KATP-2, KCNJ7, KIR3.2, KPLBS
  • Links
    NCBI Gene ID: 3763
    neXtProt AC: NX_P48051
    UniProt: P48051

  • Chr Location
    21q22.13; chr21:37624223-37916438 (-)  GRCh38.p7

Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    77 phenotypes from 3 alleles in 10 genetic backgrounds
    9 phenotypes from multigenic genotypes
    1 images
    257 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
A spontaneous mutation exhibits small size, ataxia, hypotonia, high periweaning mortality, Purkinje cell defects, and male sterility. Homozygotes for a targeted null mutation exhibit increased susceptibility to spontaneous and drug-induced seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16522 NCBI Gene Model | MGI Sequence Detail 249014 C57BL/6J ±  kb
    transcript NM_001025590 RefSeq | MGI Sequence Detail 3637 C57BL/6  
    polypeptide P48542 UniProt | EBI | MGI Sequence Detail 425 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 11
      cDNA 20
      Primer pair 7
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-15467, MGD-MRK-28073
    References
    more
    • Summaries
      All 337
      Developmental Gene Expression 22
      Diseases 3
      Gene Ontology 8
      Phenotypes 257
    • Earliest
      J:5294 Rezai Z, et al., Abnormal rate of granule cell migration in the cerebellum of Weaver mutant mice. Dev Biol. 1972 Sep;29(1):17-26
    • Latest
      J:265374 Gonzalez JC, et al., Constitutive and Synaptic Activation of GIRK Channels Differentiates Mature and Newborn Dentate Granule Cells. J Neurosci. 2018 Jul 18;38(29):6513-6526

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory