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Kcnj6
Gene Detail
Symbol

Name
ID
Kcnj6
potassium inwardly-rectifying channel, subfamily J, member 6
MGI:104781
Synonyms
GIRK2, KCNJ7, Kir3.2
Feature Type
protein coding gene
Genetic Map
Chromosome 16
55.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr16:94749266-94997696 bp, - strand
From Ensembl annotation of GRCm38

  248431 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1688  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KCNJ6
Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj6

Human
homologs
KCNJ6, potassium channel, inwardly rectifying subfamily J, member 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3763
neXtProt AC: NX_P48051

Human Synonyms: BIR1, GIRK2, GIRK-2, hiGIRK2, KATP2, KATP-2, KCNJ7, KIR3.2, KPLBS

Human Chr (Location): 21q22.1; chr21:37617482-37919731 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KCNJ6

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Spontaneous(1) Targeted(6)
Genomic Mutations involving Kcnj6 (5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
A spontaneous mutation exhibits small size, ataxia, hypotonia, high periweaning mortality, Purkinje cell defects, and male sterility. Homozygotes for a targeted null mutation exhibit increased susceptibility to spontaneous and drug-induced seizures.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Kcnj6 interacts with 306 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process ion transport, potassium ion import, ...
Component axon, cell surface, ...
Function G-protein activated inward rectifier potassium channel activity, G-protein alpha-subunit binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (346)    Tissues (183)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 271
RT-PCR 75
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) Genomic(11) cDNA(19) Primer pair(7)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000043301 (Evidence)
Entrez Gene 16522 (Evidence)
UniGene 328720
DFCI TC1586450, TC1589017, TC1591533, TC1594041, TC1591775
DoTS DT.40167239, DT.91338206, DT.101265821, DT.91279633, DT.55225529, DT.87047690, DT.87034086
NIA Mouse Gene Index U111595
PDB 3AGW, 2E4F, 3ATB, 3SYA, 3ATA, 3AUW, 3ATD, 3ATF, 3ATE, 3SYP, 3SYO, 3SYC, 3SYQ, 4KFM, 3VSQ, 3AT9, 3AT8
Consensus CDS Project CCDS37408.1, CCDS37409.1, CCDS49921.1
International Mouse Phenotyping Consortium Status Kcnj6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043301 Ensembl Gene Model | MGI Sequence Detail 248431 C57BL/6J ±  kb
transcript ENSMUST00000099508 Ensembl | MGI Sequence Detail 3086 Not Applicable 
polypeptide ENSMUSP00000097108 Ensembl | MGI Sequence Detail 425 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(10) UniProt(5)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(1951 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR016449 Potassium channel, inwardly rectifying, Kir
InterPro IPR003275 Potassium channel, inwardly rectifying, Kir3.2
InterPro IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology PR:000002003 G protein-activated inward rectifier potassium channel 2
References
(Earliest) J:13422 Lane PW, Weaver, wv. Mouse News Lett. 1964;30:32
(Latest) J:221645 Kotecki L, et al., GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner. J Neurosci. 2015 May 6;35(18):7131-42
All references(292)
Other
accession IDs
MGD-MRK-15467, MGD-MRK-28073

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory