Kcnj6
Gene Detail

Symbol Name ID

Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 MGI:104781

Synonyms

GIRK2, KCNJ7, Kir3.2

Feature Type

protein coding gene

Genetic Map

Chromosome 16

55.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)

Sequence Map

Chr16:94749266-94997696 bp, - strand From Ensembl annotation of GRCm38   248431 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1688  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj6

Human homologs

Human Homolog		KCNJ6, potassium inwardly-rectifying channel, subfamily J, member 6
NCBI Gene ID		3763
neXtProt AC		NX_P48051
Human Synonyms		BIR1, GIRK2, GIRK-2, hiGIRK2, KATP2, KATP-2, KCNJ7, KIR3.2
Human Chr (Location)		21q22.1; chr21:38996778-39288741 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(1) Gene trapped(1) Spontaneous(1)
 

A spontaneous mutation exhibits small size, ataxia, hypotonia, high periweaning mortality, Purkinje cell defects, and male sterility. Homozygotes for a targeted null mutation exhibit increased susceptibility to spontaneous and drug-induced seizures.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	ion transport, potassium ion transport, ...
Component	axon, cell surface, ...
Function	G-protein activated inward rectifier potassium channel activity, G-protein alpha-subunit binding, ...

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (346)    Tissues (181)    Images (19)
Theiler Stages: 13, 15, 16, 17, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	271
RT-PCR	75

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(37) Genomic(11) cDNA(19) Primer pair(7)
Microarray probesets(8)

Other database links

Ensembl Gene Model	ENSMUSG00000043301 (Evidence)
Entrez Gene	16522 (Evidence)
UniGene	328720
DFCI	TC1586450, TC1589017, TC1591533, TC1591775, TC1594041
DoTS	DT.101265821, DT.40167239, DT.55225529, DT.87034086, DT.87047690, DT.91279633, DT.91338206
NIA Mouse Gene Index	U111595
PDB	2E4F, 3AGW, 3ATA, 3ATB, 3ATD, 3ATE, 3ATF, 3AUW, 3SYA, 3SYC, 3SYO, 3SYP, 3SYQ, 3AT8, 3AT9
Consensus CDS Project	CCDS37408.1, CCDS37409.1, CCDS49921.1
International Mouse Knockout Project Status	Kcnj6

Sequences

Length	Strain/Species
genomic	ENSMUSG00000043301	Ensembl Gene Model | MGI Sequence Detail	248431	C57BL/6J
transcript	ENSMUST00000099508	Ensembl | MGI Sequence Detail	3086	Not Applicable
polypeptide	ENSMUSP00000097108	Ensembl | MGI Sequence Detail	425	Not Applicable

All sequences(61) RefSeq(8) UniProt(5)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(1510 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR016449	Potassium channel, inwardly rectifying, Kir
InterPro	IPR003275	Potassium channel, inwardly rectifying, Kir3.2
InterPro	IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology	PR:000002003	G protein-activated inward rectifier potassium channel 2

References

(Earliest) J:13422 Lane PW, Weaver, wv. Mouse News Lett. 1964;30:32
(Latest) J:193529 Aguado C, et al., Differential maturation of GIRK2-expressing neurons in the mouse cerebellum. J Chem Neuroanat. 2013 Jan;47:79-89
All references(289)

Other accession IDs

MGD-MRK-15467, MGD-MRK-28073