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Adra1b
Gene Detail
Symbol

Name
ID
Adra1b
adrenergic receptor, alpha 1b
MGI:104774
Synonyms
alpha1B-adrenergic receptor
Feature Type
protein coding gene
Genetic Map
Chromosome 11
25.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr11:43774606-43901210 bp, - strand
From VEGA annotation of GRCm38

  126605 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55477  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: ADRA1B
Protein SuperFamily: alpha-1 adrenergic receptor
Gene Tree: Adra1b

Human
homologs
ADRA1B, adrenoceptor alpha 1B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 147
neXtProt AC: NX_P35368

Human Synonyms: ADRA1, ALPHA1BAR

Human Chr (Location): 5q33.3; chr5:159916733-159986178 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(1) Transgenic(1)
Incidental mutations (data from APF )
 
Targeted mutations that inactivate the gene affect atrial contractility and left ventricle function, suggesting their use in modeling chronic heart failure in humans.
 
Interactions
Adra1b interacts with 226 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (82)    Tissues (53)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 64
RT-PCR 18
cDNA source data(13)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: ZFIN adra1bb    NEW 
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(14) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005462 (Evidence)
Ensembl Gene Model ENSMUSG00000050541 (Evidence)
Entrez Gene 11548 (Evidence)
DFCI TC1636872, TC1583084
DoTS DT.91337064, DT.482613, DT.101280064
NIA Mouse Gene Index U032682
Consensus CDS Project CCDS24562.1
International Mouse Phenotyping Consortium Status Adra1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005462 VEGA Gene Model | MGI Sequence Detail 126605 C57BL/6J ±  kb
transcript OTTMUST00000012162 VEGA | MGI Sequence Detail 3331 Not Applicable 
polypeptide OTTMUSP00000005616 VEGA | MGI Sequence Detail 515 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(8) UniProt(5)
Polymorphisms
RFLP(4) : SNPs within 2kb(593 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002233 Adrenergic receptor
InterPro IPR001115 Adrenergic receptor alpha-1B
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001184 alpha-1B adrenergic receptor
References
(Earliest) J:10323 Yang-Feng TL, et al., Chromosomal organization of adrenergic receptor genes. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1516-20
(Latest) J:216177 Labialle S, et al., The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. EMBO J. 2014 Oct 1;33(19):2216-30
All references(88)
Other
accession IDs
MGD-MRK-28066

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory