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Adra1b
Gene Detail
 Symbol
Name
ID
Adra1b
adrenergic receptor, alpha 1b
MGI:104774
Synonyms alpha1B-adrenergic receptor
Feature Type protein coding gene
Genetic Map
Chromosome 11
25.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr11:43774606-43901210 bp, - strand
From VEGA annotation of GRCm38

  126605 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55477  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: alpha-1 adrenergic receptor
Gene Tree: Adra1b

Human
homologs
Human Homolog ADRA1B, adrenoceptor alpha 1B
NCBI Gene ID 147
neXtProt AC  NX_P35368
Human Synonyms  ADRA1, ALPHA1BAR
Human Chr (Location)  5q33.3; chr5:159916733-159985786 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from APF )
 
Targeted mutations that inactivate the gene affect atrial contractility and left ventricle function, suggesting their use in modeling chronic heart failure in humans.
 
Interactions
Adra1b interacts with 227 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process adrenergic receptor signaling pathway, adult heart development, ...
Component cytosol, integral component of membrane, ...
Function adrenergic receptor activity, alpha1-adrenergic receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (82)    Tissues (52)    Images (15)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 64
RT-PCR 18
cDNA source data(13)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(14) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005462 (Evidence)
Ensembl Gene ModelENSMUSG00000050541 (Evidence)
Entrez Gene11548 (Evidence)
DFCITC1583084, TC1636872
DoTSDT.101280064, DT.482613, DT.91337064
NIA Mouse Gene IndexU032682
Consensus CDS ProjectCCDS24562.1
International Mouse Knockout Project StatusAdra1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005462 VEGA Gene Model | MGI Sequence Detail 126605 C57BL/6J ±  kb
transcript OTTMUST00000012162 VEGA | MGI Sequence Detail 3331 Not Applicable 
polypeptide OTTMUSP00000005616 VEGA | MGI Sequence Detail 515 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(6) UniProt(5)
Polymorphisms RFLP(4) : SNPs within 2kb(593 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002233 Adrenergic receptor
InterPro IPR001115 Adrenergic receptor alpha-1B
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001184 alpha-1B adrenergic receptor
References (Earliest) J:10323 Yang-Feng TL, et al., Chromosomal organization of adrenergic receptor genes. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1516-20
(Latest) J:190498 Telegdy G, et al., Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice. Behav Brain Res. 2012 Jul 15;233(1):232-6
All references(88)
Other
accession IDs
MGD-MRK-28066

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory