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Adra1a
Gene Detail
Symbol

Name
ID
Adra1a
adrenergic receptor, alpha 1a
MGI:104773
Synonyms
Adra1c
Feature Type
protein coding gene
Genetic Map
Chromosome 14
34.60 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:66635251-66733462 bp, + strand
From VEGA annotation of GRCm38

  98212 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68078  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADRA1A
Protein SuperFamily: alpha-1 adrenergic receptor
Gene Tree: Adra1a

Human
homologs
ADRA1A, adrenoceptor alpha 1A
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 148
neXtProt AC: NX_P35348

Human Synonyms: ADRA1C, ADRA1L1, ALPHA1AAR

Human Chr (Location): 8p21.2; chr8:26742847-26871008 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutations in this gene result in hypotension.
 
Interactions
Adra1a interacts with 241 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (46)    Tissues (24)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 12
In situ reporter (knock in) 26
RT-PCR 8
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100492776    NEW 
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000034681 (Evidence)
Ensembl Gene Model ENSMUSG00000045875 (Evidence)
Entrez Gene 11549 (Evidence)
UniGene 57064
DFCI TC1591599, TC1588691, TC1594911, TC1670557
DoTS DT.91431272, DT.101717947, DT.91373621, DT.91328458
NIA Mouse Gene Index U015787
Consensus CDS Project CCDS27223.1, CCDS70600.1
International Mouse Phenotyping Consortium Status Adra1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034681 VEGA Gene Model | MGI Sequence Detail 98212 C57BL/6J ±  kb
transcript OTTMUST00000088033 VEGA | MGI Sequence Detail 4137 Not Applicable 
polypeptide OTTMUSP00000047959 VEGA | MGI Sequence Detail 466 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(22) UniProt(4)
Polymorphisms
SNPs within 2kb(751 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002233 Adrenergic receptor
InterPro IPR001004 Adrenergic receptor alpha 1C subtype
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001183 alpha-1A adrenergic receptor
References
(Earliest) J:14806 Serfas MS, et al., HNF-1 alpha and HNF-1 beta expression in mouse intestinal crypts. Am J Physiol. 1993 Sep;265(3 Pt 1):G506-13
(Latest) J:215788 Niedermair T, et al., Absence of substance P and the sympathetic nervous system impact on bone structure and chondrocyte differentiation in an adult model of endochondral ossification. Matrix Biol. 2014 Sep;38:22-35
All references(65)
Other
accession IDs
MGD-MRK-28065

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory