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Adra1a
Gene Detail
 Symbol
Name
ID
Adra1a
adrenergic receptor, alpha 1a
MGI:104773
Synonyms Adra1c
Feature Type protein coding gene
Genetic Map
Chromosome 14
34.60 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:66635251-66733462 bp, + strand
From VEGA annotation of GRCm38

  98212 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68078  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: alpha-1 adrenergic receptor
Gene Tree: Adra1a

Human
homologs
Human Homolog ADRA1A, adrenoceptor alpha 1A
NCBI Gene ID 148
neXtProt AC  NX_P35348
Human Synonyms  ADRA1C, ADRA1L1, ALPHA1AAR
Human Chr (Location)  8p21.2; chr8:26747938-26869486 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene result in hypotension.
 
Interactions
Adra1a interacts with 242 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process activation of phospholipase C activity, adrenergic receptor signaling pathway, ...
Component cytosol, integral component of membrane, ...
Function adrenergic receptor activity, alpha1-adrenergic receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (46)    Tissues (24)    Images (15)
Theiler Stages: 20, 23, 28
Assay TypeResults
RNA in situ 12
In situ reporter (knock in) 26
RT-PCR 8
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034681 (Evidence)
Ensembl Gene ModelENSMUSG00000045875 (Evidence)
Entrez Gene11549 (Evidence)
UniGene57064
DFCITC1588691, TC1591599, TC1594911, TC1670557
DoTSDT.101717947, DT.91328458, DT.91373621, DT.91431272
NIA Mouse Gene IndexU015787
Consensus CDS ProjectCCDS27223.1, CCDS70600.1
International Mouse Knockout Project StatusAdra1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034681 VEGA Gene Model | MGI Sequence Detail 98212 C57BL/6J ±  kb
transcript OTTMUST00000088035 VEGA | MGI Sequence Detail 4282 Not Applicable 
polypeptide OTTMUSP00000047961 VEGA | MGI Sequence Detail 466 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(20) UniProt(4)
Polymorphisms SNPs within 2kb(751 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002233 Adrenergic receptor
InterPro IPR001004 Adrenergic receptor alpha 1C subtype
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001183 alpha-1A adrenergic receptor
References (Earliest) J:14806 Serfas MS, et al., HNF-1 alpha and HNF-1 beta expression in mouse intestinal crypts. Am J Physiol. 1993 Sep;265(3 Pt 1):G506-13
(Latest) J:205510 White CW, et al., Male contraception via simultaneous knockout of alpha1A-adrenoceptors and P2X1-purinoceptors in mice. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20825-30
All references(63)
Other
accession IDs
MGD-MRK-28065

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory