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Fkbp10 Gene Detail
Summary
  • Symbol
    Fkbp10
  • Name
    FK506 binding protein 10
  • Synonyms
    65kDa, Fkbp1-rs, Fkbp6, FKBP65, Fkbp-rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104769
    NCBI Gene: 14230
  • Gene Overview
    MyGene.info: FKBP10
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100415697-100424824 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.47 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104769
protein coding gene Chr11:100415694-100424840 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019154
protein coding gene Chr11:103174052-103184516 (+)
A/J MGP_AJ_G0019122
protein coding gene Chr11:98863492-98873981 (+)
AKR/J MGP_AKRJ_G0019091
protein coding gene Chr11:101911462-101920145 (+)
BALB/cJ MGP_BALBcJ_G0019096
protein coding gene Chr11:99343925-99353038 (+)
C3H/HeJ MGP_C3HHeJ_G0018905
protein coding gene Chr11:102107715-102119591 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019545
protein coding gene Chr11:106379715-106392793 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017171
protein coding gene Chr11:96280943-96290019 (+)
CAST/EiJ MGP_CASTEiJ_G0018459
protein coding gene Chr11:103079825-103089649 (+)
CBA/J MGP_CBAJ_G0018874
protein coding gene Chr11:110805799-110814906 (+)
DBA/2J MGP_DBA2J_G0018986
protein coding gene Chr11:98401930-98411322 (+)
FVB/NJ MGP_FVBNJ_G0018976
protein coding gene Chr11:97933349-97943100 (+)
LP/J MGP_LPJ_G0019055
protein coding gene Chr11:103719113-103731016 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019007
protein coding gene Chr11:110418155-110428876 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019583
protein coding gene Chr11:102254699-102264485 (+)
PWK/PhJ MGP_PWKPhJ_G0018222
protein coding gene Chr11:99439339-99449814 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018014
protein coding gene Chr11:101971037-101984825 (+)
WSB/EiJ MGP_WSBEiJ_G0018508
protein coding gene Chr11:102239446-102249166 (+)



Homology
more
  • Human Ortholog
    FKBP10, FKBP prolyl isomerase 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FKBP10, FKBP prolyl isomerase 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRKS1, FKBP65, hFKBP65, OI11, OI6, PPIASE
  • Links
    NCBI Gene ID: 60681
    neXtProt AC: NX_Q96AY3
    UniProt: Q96AY3

  • Chr Location
    17q21.2; chr17:41812262-41823217 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7718
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FKBP10
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human FKBP10 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 2 genetic backgrounds
    3 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice do not survive birth, and embryos exhibit delayed growth, tissue fragility, decreased aorta wall thickness, craniofacial and forelimb anomalies, and connective tissue alterations. Mutant MEFs retain procollagen in the cell layer and show dilated endoplasmic reticulum.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001555 Ensembl Gene Model | MGI Sequence Detail 9128 C57BL/6J ±  kb
    transcript ENSMUST00000001595 Ensembl | MGI Sequence Detail 2584 Not Applicable  
    polypeptide ENSMUSP00000001595 Ensembl | MGI Sequence Detail 581 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • EC
    • InterPro Domains
      IPR018247 EF-Hand 1, calcium-binding site
      IPR002048 EF-hand domain
      IPR011992 EF-hand domain pair
      IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
      IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
    Molecular
    Reagents
    less
    • All nucleic 107
      cDNA 107

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-28060, MGD-MRK-9809, MGI:2144131, MGI:95540
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 16
    • Earliest
      J:15604 Simek SL, et al., Sequence and localization of a novel FK506-binding protein to mouse chromosome 11. Genomics. 1993 Nov;18(2):407-9
    • Latest
      J:255301 Lietman CD, et al., Fkbp10 Deletion in Osteoblasts Leads to Qualitative Defects in Bone. J Bone Miner Res. 2017 Jun;32(6):1354-1367

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory