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Fkbp10
Gene Detail
Symbol

Name
ID
Fkbp10
FK506 binding protein 10
MGI:104769
Synonyms
65kDa, Fkbp1-rs, Fkbp6, FKBP65, Fkbp-rs1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
63.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr11:100415697-100424824 bp, + strand
From VEGA annotation of GRCm38

  9128 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7718  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FKBP10
Gene Tree: Fkbp10

Human
homologs
FKBP10, FK506 binding protein 10, 65 kDa
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 60681
neXtProt AC: NX_Q96AY3

Human Synonyms: BRKS1, FKBP65, hFKBP65, OI11, OI6, PPIASE

Human Chr (Location): 17q21.2; chr17:41812262-41823217 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human FKBP10

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Genomic Mutations involving Fkbp10 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Fkbp10 interacts with 119 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process chaperone-mediated protein folding, protein folding, ...
Component cytoplasm, endoplasmic reticulum, ...
Function calcium ion binding, FK506 binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (26)    Tissues (25)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 26
cDNA source data(106)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fkbp10 ; ZFIN fkbp10b    NEW 
Molecular
reagents
All nucleic(106) cDNA(106)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000006274 (Evidence)
Ensembl Gene Model ENSMUSG00000001555 (Evidence)
Entrez Gene 14230 (Evidence)
UniGene 3894
DFCI TC1572591
DoTS DT.91358033
NIA Mouse Gene Index U013338
EC 5.2.1.8
Consensus CDS Project CCDS25422.1
International Mouse Phenotyping Consortium Status Fkbp10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006274 VEGA Gene Model | MGI Sequence Detail 9128 C57BL/6J ±  kb
transcript OTTMUST00000014190 VEGA | MGI Sequence Detail 2584 Not Applicable 
polypeptide OTTMUSP00000006589 VEGA | MGI Sequence Detail 581 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(86 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
InterPro IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
Protein Ontology PR:000007532 peptidyl-prolyl cis-trans isomerase FKBP10
References
(Earliest) J:15604 Simek SL, et al., Sequence and localization of a novel FK506-binding protein to mouse chromosome 11. Genomics. 1993 Nov;18(2):407-9
(Latest) J:213596 Lietman CD, et al., Connective tissue alterations in Fkbp10-/- mice. Hum Mol Genet. 2014 Sep 15;23(18):4822-31
All references(43)
Other
accession IDs
MGD-MRK-28060, MGD-MRK-9809, MGI:2144131, MGI:95540

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory