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Gast
Gene Detail
 Symbol
Name
ID
Gast
gastrin
MGI:104768
Synonyms GAS
Feature Type protein coding gene
Genetic Map
Chromosome 11
63.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr11:100334407-100336996 bp, + strand
From VEGA annotation of GRCm38

  2590 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:628  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: gastrin
Gene Tree: Gast

Human
homologs
Human Homolog GAST, gastrin
NCBI Gene ID 2520
neXtProt AC  NX_P01350
Human Synonyms  GAS
Human Chr (Location)  17q21; chr17:41712326-41715969 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Targeted(6)
 
Homozygotes for targeted null alleles exhibit an absence of gastric acid secretion, alterations in gastric architecture, fasting hypoglycemia with impaired glucagon response, and increased susceptibility to azoxymethane-induced colon tumors.
 
Interactions
Gast interacts with 10 markers (Mir19b-1, Mir19b-2, Mir184, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process G-protein coupled receptor signaling pathway, signal transduction
Component extracellular region
Function hormone activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (20)    Tissues (11)    Images (14)
Theiler Stages: 19, 21, 22, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 9
RT-PCR 8
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(10) cDNA(16) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000006278 (Evidence)
Ensembl Gene ModelENSMUSG00000017165 (Evidence)
Entrez Gene14459 (Evidence)
UniGene4767
DFCITC1584996
DoTSDT.55118143, DT.55134331
NIA Mouse Gene IndexU013337
Consensus CDS ProjectCCDS25418.1
International Mouse Knockout Project StatusGast
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006278 VEGA Gene Model | MGI Sequence Detail 2590 C57BL/6J ±  kb
transcript OTTMUST00000014209 VEGA | MGI Sequence Detail 460 Not Applicable 
polypeptide OTTMUSP00000006598 VEGA | MGI Sequence Detail 101 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013152 Gastrin/cholecystokinin, conserved site
InterPro IPR001651 Gastrin/cholecystokinin peptide hormone
Protein Ontology PR:000007856 gastrin
References (Earliest) J:78615 Wang TC, et al., Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells. J Clin Invest. 1993 Sep;92(3):1349-56
(Latest) J:205763 Suissa Y, et al., Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas. PLoS One. 2013;8(8):e70397
All references(114)
Other
accession IDs
MGD-MRK-28059

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory