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Gene Detail
neuronal cell adhesion molecule
Synonyms Bravo, C030017F07Rik, C130076O07Rik, mKIAA0343
Feature Type protein coding gene
Genetic Map
Chromosome 12
20.71 cM
Detailed Genetic Map ± 1 cM

Mapping data(4)
Sequence Map
Chr12:44328885-44601846 bp, + strand
From NCBI annotation of GRCm38

  272962 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:21041  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: neural cell adhesion molecule-like protein
Gene Tree: Nrcam

Human Homolog NRCAM, neuronal cell adhesion molecule
NCBI Gene ID 4897
neXtProt AC  NX_Q92823
Human Chr (Location)  7q31; chr7:108147626-108456717 (-)  GRCh38
alleles, and
All mutations/alleles(10) : Chemically induced (ENU)(1) Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for targeted null mutations exhibit disorganization of lens fibers, cellular disintegration, and accumulation of cellular debris resulting in cataracts. Mutants show mild reductions in cerebellar lobe size.
Human Diseases Modeled Using Mouse Nrcam (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)
Nrcam interacts with 371 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (21 annotations)
Process axon guidance, cell adhesion, ...
Component axon, axon initial segment, ...
Function ankyrin binding, protein binding, ...
External Resources: FuncBase
Literature Summary: (22 records)
Data Summary: Results (154)    Tissues (123)    Images (47)
Theiler Stages: 18, 19, 20, 21, 22, 24, 27, 28
Assay TypeResults
Immunohistochemistry 56
RNA in situ 97
Western blot 1
cDNA source data(96)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(98) cDNA(96) Other(2)
Microarray probesets(3)
Other database
Ensembl Gene ModelENSMUSG00000020598 (Evidence)
Entrez Gene319504 (Evidence)
DFCITC1578008, TC1585815, TC1586894, TC1593284, TC1599446, TC1610207, TC1611015, TC1628337, TC1640287, TC1737812
DoTSDT.101382254, DT.101382255, DT.101382257, DT.101382259, DT.101738191, DT.101738192, DT.110920002, DT.110920011, DT.110920041, DT.40172953, DT.55224115, DT.91443873, DT.94271043
NIA Mouse Gene IndexU013910
Consensus CDS ProjectCCDS49056.1, CCDS49057.1
International Mouse Knockout Project StatusNrcam
Representative SequencesLengthStrain/SpeciesFlank
genomic 319504 NCBI Gene Model | MGI Sequence Detail 272962 C57BL/6J ±  kb
transcript NM_176930 RefSeq | MGI Sequence Detail 7572 C57BL/6 
polypeptide Q810U4 UniProt | EBI | MGI Sequence Detail 1256 Not Applicable 

For the selected sequences
All sequences(124) RefSeq(58) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(2907 from dbSNP Build 137)
InterPro IPR003961 Fibronectin, type III
InterPro IPR026966 Fibronectin type III C-terminal domain
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000011420 neuronal cell adhesion molecule
Graphical View of Protein Domain Structure
References (Earliest) J:22422 Moscoso LM, et al., Expression of four immunoglobulin superfamily adhesion molecules (L1, Nr-CAM/Bravo, neurofascin/ABGP, and N-CAM) in the developing mouse spinal cord. J Comp Neurol. 1995 Feb 13;352(3):321-34
(Latest) J:208118 Amor V, et al., Long-Term Maintenance of Na+ Channels at Nodes of Ranvier Depends on Glial Contact Mediated by Gliomedin and NrCAM. J Neurosci. 2014 Apr 9;34(15):5089-98
All references(72)
Disease annotation references (1)
accession IDs
MGD-MRK-28041, MGI:1924717, MGI:2442157

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory