Nrcam
Gene Detail

Symbol Name ID

Nrcam neuron-glia-CAM-related cell adhesion molecule MGI:104750

Synonyms

Bravo, C030017F07Rik, C130076O07Rik, mKIAA0343

Feature Type

protein coding gene

Genetic Map

Chromosome 12

20.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr12:44328885-44601846 bp, + strand From NCBI annotation of GRCm38   272962 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21041  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: neural cell adhesion molecule-like protein
Gene Tree: Nrcam

Human homologs

Human Homolog		NRCAM, neuronal cell adhesion molecule
NCBI Gene ID		4897
neXtProt AC		NX_Q92823
Human Chr (Location)		7q31; chr7:107788071-108096841 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(7) Gene trapped(2) Chemically induced(1)
 

Homozygotes for targeted null mutations exhibit disorganization of lens fibers, cellular disintegration, and accumulation of cellular debris resulting in cataracts. Mutants show mild reductions in cerebellar lobe size.

 
Human Diseases Modeled Using Mouse Nrcam (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	axon guidance, cell adhesion, ...
Component	axon, axon initial segment, ...
Function	ankyrin binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (22 records)
Data Summary: Results (154)    Tissues (123)    Images (47)
Theiler Stages: 18, 19, 20, 21, 22, 24, 28

Assay Type	Results
Immunohistochemistry	56
RNA in situ	97
Western blot	1

cDNA source data(96)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(98) cDNA(96) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000020598 (Evidence)
Entrez Gene	319504 (Evidence)
UniGene	208439
DFCI	TC1578008, TC1585815, TC1586894, TC1593284, TC1599446, TC1610207, TC1611015, TC1628337, TC1640287, TC1737812
DoTS	DT.101382254, DT.101382255, DT.101382257, DT.101382259, DT.101738191, DT.101738192, DT.110920002, DT.110920011, DT.110920041, DT.40172953, DT.55224115, DT.91443873, DT.94271043
NIA Mouse Gene Index	U013910
Consensus CDS Project	CCDS49056.1, CCDS49057.1
International Mouse Knockout Project Status	Nrcam

Sequences

Length	Strain/Species
genomic	319504	NCBI Gene Model | MGI Sequence Detail	272962	C57BL/6J
transcript	NM_176930	RefSeq | MGI Sequence Detail	7572	C57BL/6
polypeptide	Q810U4	UniProt | EBI | MGI Sequence Detail	1256	Not Applicable

All sequences(70) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(2045 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR026966	Fibronectin type III C-terminal domain
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
Protein Ontology	PR:000011420	neuronal cell adhesion molecule

Graphical View of Protein Domain Structure

References

(Earliest) J:22422 Moscoso LM, et al., Expression of four immunoglobulin superfamily adhesion molecules (L1, Nr-CAM/Bravo, neurofascin/ABGP, and N-CAM) in the developing mouse spinal cord. J Comp Neurol. 1995 Feb 13;352(3):321-34
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(69)

Other accession IDs

MGD-MRK-28041, MGI:1924717, MGI:2442157