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Nrcam
Gene Detail
Symbol

Name
ID
Nrcam
neuronal cell adhesion molecule
MGI:104750
Synonyms
Bravo, C030017F07Rik, C130076O07Rik, mKIAA0343
Feature Type
protein coding gene
Genetic Map
Chromosome 12
20.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr12:44328885-44601846 bp, + strand
From Ensembl annotation of GRCm38

  272962 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21041  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: neural cell adhesion molecule-like protein
Gene Tree: Nrcam

Human
homologs
Human Homolog NRCAM, neuronal cell adhesion molecule
NCBI Gene ID 4897
neXtProt AC  NX_Q92823
Human Chr (Location)  7q31; chr7:108147626-108456717 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit disorganization of lens fibers, cellular disintegration, and accumulation of cellular debris resulting in cataracts. Mutants show mild reductions in cerebellar lobe size.
 
Human Diseases Modeled Using Mouse Nrcam (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)
Interactions
Nrcam interacts with 371 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process axon guidance, cell adhesion, ...
Component axon, axon initial segment, ...
Function ankyrin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (154)    Tissues (123)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 56
RNA in situ 97
Western blot 1
cDNA source data(96)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(98) cDNA(96) Other(2)
Microarray probesets(3)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020598 Ensembl Gene Model | MGI Sequence Detail 272962 C57BL/6J ±  kb
transcript ENSMUST00000020939 Ensembl | MGI Sequence Detail 7572 Not Applicable 
polypeptide ENSMUSP00000020939 Ensembl | MGI Sequence Detail 1256 Not Applicable 

For the selected sequences
All sequences(126) RefSeq(58) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(2907 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR026966 Fibronectin type III C-terminal domain
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000011420 neuronal cell adhesion molecule
References
(Earliest) J:22422 Moscoso LM, et al., Expression of four immunoglobulin superfamily adhesion molecules (L1, Nr-CAM/Bravo, neurofascin/ABGP, and N-CAM) in the developing mouse spinal cord. J Comp Neurol. 1995 Feb 13;352(3):321-34
(Latest) J:213066 Namba T, et al., Pioneering axons regulate neuronal polarization in the developing cerebral cortex. Neuron. 2014 Feb 19;81(4):814-29
All references(73)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-28041, MGI:1924717, MGI:2442157

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory