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Nrcam Gene Detail
Summary
  • Symbol
    Nrcam
  • Name
    neuronal cell adhesion molecule
  • Synonyms
    Bravo, C030017F07Rik, C130076O07Rik, mKIAA0343
  • Feature Type
    protein coding gene
  • IDs
    MGI:104750
    NCBI Gene: 319504
  • Gene Overview
    MyGene.info: NRCAM
Location & Maps
more
  • Sequence Map
    Chr12:44328885-44601846 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      272962 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NRCAM, neuronal cell adhesion molecule
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NRCAM, neuronal cell adhesion molecule
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 4897
    neXtProt AC: NX_Q92823

  • Chr Location
    7q31; chr7:108147626-108456397 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Nrcam mouse models

Human Disease Mouse Models
       Autism   OMIM: 209850 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 7 genetic backgrounds
    28 phenotypes from multigenic genotypes
    4 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    2
  • Gene trapped
    2
  • Targeted
    7
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit disorganization of lens fibers, cellular disintegration, and accumulation of cellular debris resulting in cataracts. Mutants show mild reductions in cerebellar lobe size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020598 Ensembl Gene Model | MGI Sequence Detail 272962 C57BL/6J ±  kb
transcript ENSMUST00000020939 Ensembl | MGI Sequence Detail 7572 Not Applicable  
polypeptide ENSMUSP00000020939 Ensembl | MGI Sequence Detail 1256 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    2890 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011420 neuronal cell adhesion molecule
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013098 Immunoglobulin I-set
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR026966 Neurofascin/L1/NrCAM, C-terminal domain
Molecular
Reagents
less
  • All nucleic 99
    cDNA 96
    Primer pair 1
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-28041, MGI:1924717, MGI:2442157
References
more
  • Summaries
    All 72
    Developmental Gene Expression 24
    Diseases 1
    Gene Ontology 9
    Phenotypes 26
  • Earliest
    J:22422 Moscoso LM, et al., Expression of four immunoglobulin superfamily adhesion molecules (L1, Nr-CAM/Bravo, neurofascin/ABGP, and N-CAM) in the developing mouse spinal cord. J Comp Neurol. 1995 Feb 13;352(3):321-34
  • Latest
    J:219896 Zhang A, et al., Neurofascin 140 is an embryonic neuronal neurofascin isoform that promotes the assembly of the node of Ranvier. J Neurosci. 2015 Feb 4;35(5):2246-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory