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Osm Gene Detail
Summary
  • Symbol
    Osm
  • Name
    oncostatin M
  • Synonyms
    OncoM
  • Feature Type
    protein coding gene
  • IDs
    MGI:104749
    NCBI Gene: 18413
  • Gene Overview
    MyGene.info: OSM
Location & Maps
more
  • Genetic Map
    Chromosome 11, 2.94 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    OSM, oncostatin M
  • Vertebrate Orthologs
    7
  • Human Ortholog
    OSM, oncostatin M
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 5008
    neXtProt AC: NX_P13725

  • Chr Location
    22q12.2; chr22:30262826-30266840 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice display decreased noxious responses in models of acute thermal, mechanical, chemical, and visceral pain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005054 VEGA Gene Model | MGI Sequence Detail 4607 C57BL/6J ±  kb
transcript OTTMUST00000011263 VEGA | MGI Sequence Detail 2272 Not Applicable  
polypeptide OTTMUSP00000005249 VEGA | MGI Sequence Detail 263 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    18 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012059 oncostatin-M
  • InterPro Domains
    IPR012351 Four-helical cytokine, core
    IPR009079 Four-helical cytokine-like, core
    IPR001581 Leukemia inhibitory factor /oncostatin
    IPR019827 Leukemia inhibitory factor /oncostatin, conserved site
Molecular
Reagents
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  • All nucleic 15
    cDNA 12
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-28040
References
more
  • Summaries
    All 65
    Developmental Gene Expression 11
    Gene Ontology 9
    Phenotypes 9
  • Earliest
    J:15716 Conover JC, et al., Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells. Development. 1993 Nov;119(3):559-65
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory