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Pkia Gene Detail
Summary
  • Symbol
    Pkia
  • Name
    protein kinase inhibitor, alpha
  • Synonyms
    PKIalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:104747
    NCBI Gene: 18767
  • Gene Overview
    MyGene.info: PKIA
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:7366669-7445366 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 1.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    887 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104747
protein coding gene Chr3:7366604-7445366 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027049
protein coding gene Chr3:4182293-4265228 (+)
A/J MGP_AJ_G0027013
protein coding gene Chr3:4462765-4545118 (+)
AKR/J MGP_AKRJ_G0026983
protein coding gene Chr3:4267089-4352669 (+)
BALB/cJ MGP_BALBcJ_G0027022
protein coding gene Chr3:4171372-4256461 (+)
C3H/HeJ MGP_C3HHeJ_G0026762
protein coding gene Chr3:4564716-4648430 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027466
protein coding gene Chr3:4730046-4814842 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024828
protein coding gene Chr3:3548556-3613448 (+)
CAST/EiJ MGP_CASTEiJ_G0026220
protein coding gene Chr3:4559455-4643324 (+)
CBA/J MGP_CBAJ_G0026740
protein coding gene Chr3:4520976-4613673 (+)
DBA/2J MGP_DBA2J_G0026876
protein coding gene Chr3:4063698-4145354 (+)
FVB/NJ MGP_FVBNJ_G0026843
protein coding gene Chr3:3912822-3997104 (+)
LP/J MGP_LPJ_G0026986
protein coding gene Chr3:4687188-4772512 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026863
protein coding gene Chr3:5562626-5659498 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027526
protein coding gene Chr3:4117607-4207563 (+)
PWK/PhJ MGP_PWKPhJ_G0025955
protein coding gene Chr3:4230197-4310812 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025758
protein coding gene Chr3:4243943-4339295 (+)
WSB/EiJ MGP_WSBEiJ_G0026291
protein coding gene Chr3:4125853-4219118 (+)



Homology
more
  • Human Ortholog
    PKIA, cAMP-dependent protein kinase inhibitor alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PKIA, cAMP-dependent protein kinase inhibitor alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PRKACN1
  • Links
    NCBI Gene ID: 5569
    neXtProt AC: NX_P61925
    UniProt: P61925

  • Chr Location
    8q21.13; chr8:78516101-78605267 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit decreased basal and isoproterenol-induced phosphoenolpyruvate carboxykinase expression in muscle, but are phenotypically normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027499 Ensembl Gene Model | MGI Sequence Detail 78698 C57BL/6J ±  kb
transcript ENSMUST00000028999 Ensembl | MGI Sequence Detail 3617 Not Applicable  
polypeptide ENSMUSP00000028999 Ensembl | MGI Sequence Detail 76 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 59
    Genomic 1
    cDNA 55
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-28038, MGI:2139695
References
more
  • Summaries
    All 44
    Developmental Gene Expression 5
    Gene Ontology 9
    Phenotypes 7
  • Earliest
    J:22811 Olsen SR, et al., Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent protein kinase. J Biol Chem. 1991 Jun 15;266(17):11158-62
  • Latest
    J:245325 Kim J, et al., Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A. Structure. 2016 Mar 01;24(3):353-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory