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Kcnj2
Gene Detail
 Symbol
Name
ID
Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
MGI:104744
Synonyms IRK1, Kcnf1, Kir2.1
Feature Type protein coding gene
Genetic Map
Chromosome 11
75.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr11:111066164-111076821 bp, + strand
From VEGA annotation of GRCm38

  10658 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20249  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj2

Human
homologs
Human Homolog KCNJ2, potassium inwardly-rectifying channel, subfamily J, member 2
NCBI Gene ID 3759
neXtProt AC  NX_P63252
Human Synonyms  ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, SQT3
Human Chr (Location)  17q24.3; chr17:70169535-70180044 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human KCNJ2
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation die within 8-12 hours after birth, displaying cyanosis and respiratory distress, as well as complete cleft of the secondary palate, and loss of K+-mediated vasodilatation in cerebral arteries.
 
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process cardiac muscle cell action potential, cardiac muscle cell action potential involved in contraction, ...
Component dendrite, dendritic spine, ...
Function identical protein binding, inward rectifier potassium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (74)    Tissues (51)    Images (13)
Theiler Stages: 23, 25, 28
Assay TypeResults
RNA in situ 22
RT-PCR 52
cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(27) Genomic(4) cDNA(20) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000003324 (Evidence)
Ensembl Gene ModelENSMUSG00000041695 (Evidence)
Entrez Gene16518 (Evidence)
UniGene4951
DFCITC1590854
DoTSDT.481857, DT.87047817
NIA Mouse Gene IndexU013507
PDB1U4F, 2GIX, 2XKY
Consensus CDS ProjectCCDS25594.1
International Mouse Knockout Project StatusKcnj2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003324 VEGA Gene Model | MGI Sequence Detail 10658 C57BL/6J ±  kb
transcript OTTMUST00000006982 VEGA | MGI Sequence Detail 5444 Not Applicable 
polypeptide OTTMUSP00000003316 VEGA | MGI Sequence Detail 428 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR016449 Potassium channel, inwardly rectifying, Kir
InterPro IPR003271 Potassium channel, inwardly rectifying, Kir2.1
InterPro IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
InterPro IPR013673 Potassium channel, inwardly rectifying, Kir, N-terminal
Protein Ontology PR:000002056 inward rectifier potassium channel 2
References (Earliest) J:32220 Pravtcheva DD, et al., Timing of paternal Pgk-1 expression in embryos of transgenic mice. Development. 1991 Apr;111(4):1109-20
(Latest) J:201349 Luo X, et al., MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation. J Clin Invest. 2013 May 1;123(5):1939-51
All references(69)
Other
accession IDs
MGD-MRK-11578, MGD-MRK-28035

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory