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Kcnj2 Gene Detail
Summary
  • Symbol
    Kcnj2
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 2
  • Synonyms
    IRK1, Kcnf1, Kir2.1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104744
    NCBI Gene: 16518
  • Gene Overview
    MyGene.info: KCNJ2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:111066164-111076821 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 75.23 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    90 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104744
protein coding gene Chr11:111066164-111076825 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019347
protein coding gene Chr11:114736493-114748971 (+)
A/J MGP_AJ_G0019315
protein coding gene Chr11:109772432-109784163 (+)
AKR/J MGP_AKRJ_G0019284
protein coding gene Chr11:113037412-113048091 (+)
BALB/cJ MGP_BALBcJ_G0019289
protein coding gene Chr11:110204701-110215996 (+)
C3H/HeJ MGP_C3HHeJ_G0019098
protein coding gene Chr11:113361383-113374058 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019739
protein coding gene Chr11:118193006-118205834 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017362
protein coding gene Chr11:106935498-106946281 (+)
CAST/EiJ MGP_CASTEiJ_G0018651
protein coding gene Chr11:114545312-114556213 (+)
CBA/J MGP_CBAJ_G0019067
protein coding gene Chr11:123028901-123041861 (+)
DBA/2J MGP_DBA2J_G0019179
protein coding gene Chr11:109242067-109252997 (+)
FVB/NJ MGP_FVBNJ_G0019170
protein coding gene Chr11:108688982-108700546 (+)
LP/J MGP_LPJ_G0019249
protein coding gene Chr11:115148158-115159584 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019201
protein coding gene Chr11:122180653-122194374 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019776
protein coding gene Chr11:113639477-113650119 (+)
PWK/PhJ MGP_PWKPhJ_G0018416
protein coding gene Chr11:110415870-110427118 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018208
protein coding gene Chr11:113446630-113457281 (+)
WSB/EiJ MGP_WSBEiJ_G0018703
protein coding gene Chr11:113573394-113589390 (+)



Homology
more
  • Human Ortholog
    KCNJ2, potassium voltage-gated channel subfamily J member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNJ2, potassium voltage-gated channel subfamily J member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, SQT3
  • Links
    NCBI Gene ID: 3759
    neXtProt AC: NX_P63252
    UniProt: P63252

  • Chr Location
    17q24.3; chr17:70169535-70180044 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with human KCNJ2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation die within 8-12 hours after birth, displaying cyanosis and respiratory distress, as well as complete cleft of the secondary palate, and loss of K+-mediated vasodilatation in cerebral arteries.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041695 Ensembl Gene Model | MGI Sequence Detail 10658 C57BL/6J ±  kb
    transcript ENSMUST00000042970 Ensembl | MGI Sequence Detail 5444 Not Applicable  
    polypeptide ENSMUSP00000037192 Ensembl | MGI Sequence Detail 428 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 5
      cDNA 20
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11578, MGD-MRK-28035
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 12
      Gene Ontology 13
      Phenotypes 9
    • Earliest
      J:32220 Pravtcheva DD, et al., Timing of paternal Pgk-1 expression in embryos of transgenic mice. Development. 1991 Apr;111(4):1109-20
    • Latest
      J:247463 Toib A, et al., Remodeling of repolarization and arrhythmia susceptibility in a myosin-binding protein C knockout mouse model. Am J Physiol Heart Circ Physiol. 2017 Sep 01;313(3):H620-H630

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory