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Kcnj2
Gene Detail
Symbol

Name
ID
Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
MGI:104744
Synonyms
IRK1, Kcnf1, Kir2.1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
75.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr11:111066164-111076821 bp, + strand
From VEGA annotation of GRCm38

  10658 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20249  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KCNJ2
Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj2

Human
homologs
KCNJ2, potassium channel, inwardly rectifying subfamily J, member 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3759
neXtProt AC: NX_P63252

Human Synonyms: ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, SQT3

Human Chr (Location): 17q24.3; chr17:70168616-70180044 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human KCNJ2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted null mutation die within 8-12 hours after birth, displaying cyanosis and respiratory distress, as well as complete cleft of the secondary palate, and loss of K+-mediated vasodilatation in cerebral arteries.
 
Interactions
Kcnj2 interacts with 406 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (74)    Tissues (53)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 22
RT-PCR 52
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase kcnj2    NEW 
Molecular
reagents
All nucleic(27) Genomic(4) cDNA(20) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000003324 (Evidence)
Ensembl Gene Model ENSMUSG00000041695 (Evidence)
Entrez Gene 16518 (Evidence)
UniGene 4951
DFCI TC1590854
DoTS DT.481857, DT.87047817
NIA Mouse Gene Index U013507
PDB 2XKY, 2GIX, 1U4F
Consensus CDS Project CCDS25594.1
International Mouse Phenotyping Consortium Status Kcnj2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003324 VEGA Gene Model | MGI Sequence Detail 10658 C57BL/6J ±  kb
transcript OTTMUST00000006982 VEGA | MGI Sequence Detail 5444 Not Applicable 
polypeptide OTTMUSP00000003316 VEGA | MGI Sequence Detail 428 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR016449 Potassium channel, inwardly rectifying, Kir
InterPro IPR003271 Potassium channel, inwardly rectifying, Kir2.1
InterPro IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
InterPro IPR013673 Potassium channel, inwardly rectifying, Kir, N-terminal
Protein Ontology PR:000002056 inward rectifier potassium channel 2
References
(Earliest) J:4135 Kubo Y, et al., Primary structure and functional expression of a mouse inward rectifier potassium channel [see comments]. Nature. 1993 Mar 11;362(6416):127-33
(Latest) J:216531 Hartman ME, et al., Myocardial deletion of transcription factor CHF1/Hey2 results in altered myocyte action potential and mild conduction system expansion but does not alter conduction system function or promote spontaneous arrhythmias. FASEB J. 2014 Jul;28(7):3007-15
All references(70)
Other
accession IDs
MGD-MRK-11578, MGD-MRK-28035

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory