Kcnj2
Gene Detail

Symbol Name ID

Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 MGI:104744

Synonyms

IRK1, Kcnf1, Kir2.1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

75.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr11:111066164-111076821 bp, + strand From VEGA annotation of GRCm38   10658 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20249  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj2

Human homologs

Human Homolog		KCNJ2, potassium inwardly-rectifying channel, subfamily J, member 2
NCBI Gene ID		3759
neXtProt AC		NX_P63252
Human Synonyms		ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, SQT3
Human Chr (Location)		17q24.3; chr17:68165676-68176185 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human KCNJ2

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a targeted null mutation die within 8-12 hours after birth, displaying cyanosis and respiratory distress, as well as complete cleft of the secondary palate, and loss of K+-mediated vasodilatation in cerebral arteries.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	ion transport, magnesium ion transport, ...
Component	dendrite, integral to membrane, ...
Function	identical protein binding, inward rectifier potassium channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (74)    Tissues (51)    Images (13)
Theiler Stages: 23, 25, 28

Assay Type	Results
RNA in situ	22
RT-PCR	52

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(4) cDNA(20) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000003324 (Evidence)
Ensembl Gene Model	ENSMUSG00000041695 (Evidence)
Entrez Gene	16518 (Evidence)
UniGene	4951
DFCI	TC1590854
DoTS	DT.481857, DT.87047817
NIA Mouse Gene Index	U013507
PDB	1U4F, 2GIX, 2XKY
Consensus CDS Project	CCDS25594.1
International Mouse Knockout Project Status	Kcnj2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003324	VEGA Gene Model | MGI Sequence Detail	10658	C57BL/6J
transcript	OTTMUST00000006982	VEGA | MGI Sequence Detail	5444	Not Applicable
polypeptide	OTTMUSP00000003316	VEGA | MGI Sequence Detail	428	Not Applicable

All sequences(24) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(8 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR016449	Potassium channel, inwardly rectifying, Kir
InterPro	IPR003271	Potassium channel, inwardly rectifying, Kir2.1
InterPro	IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic
InterPro	IPR013673	Potassium channel, inwardly rectifying, Kir, N-terminal
Protein Ontology	PR:000002056	inward rectifier potassium channel 2

References

(Earliest) J:32220 Pravtcheva DD, et al., Timing of paternal Pgk-1 expression in embryos of transgenic mice. Development. 1991 Apr;111(4):1109-20
(Latest) J:192854 Tateyama M, et al., Binding of Gq protein stabilizes the activated state of the muscarinic receptor type 1. Neuropharmacology. 2013 Feb;65:173-81
All references(67)

Other accession IDs

MGD-MRK-11578, MGD-MRK-28035