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Kcnj2 Gene Detail
Summary
  • Symbol
    Kcnj2
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 2
  • Synonyms
    IRK1, Kcnf1, Kir2.1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104744
    NCBI Gene: 16518
  • Gene Overview
    MyGene.info: KCNJ2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:111066164-111076821 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10658 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 75.23 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    KCNJ2, potassium voltage-gated channel subfamily J member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNJ2, potassium voltage-gated channel subfamily J member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, SQT3
  • Links
    NCBI Gene ID: 3759
    neXtProt AC: NX_P63252
    UniProt: P63252

  • Chr Location
    17q24.3; chr17:70169535-70180044 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with human KCNJ2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation die within 8-12 hours after birth, displaying cyanosis and respiratory distress, as well as complete cleft of the secondary palate, and loss of K+-mediated vasodilatation in cerebral arteries.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000003324 VEGA Gene Model | MGI Sequence Detail 10658 C57BL/6J ±  kb
    transcript OTTMUST00000006982 VEGA | MGI Sequence Detail 5444 Not Applicable  
    polypeptide OTTMUSP00000003316 VEGA | MGI Sequence Detail 428 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      90 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 28
      Genomic 5
      cDNA 20
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
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    MGD-MRK-11578, MGD-MRK-28035
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 11
      Gene Ontology 12
      Phenotypes 9
    • Earliest
      J:32220 Pravtcheva DD, et al., Timing of paternal Pgk-1 expression in embryos of transgenic mice. Development. 1991 Apr;111(4):1109-20
    • Latest
      J:247463 Toib A, et al., Remodeling of repolarization and arrhythmia susceptibility in a myosin-binding protein C knockout mouse model. Am J Physiol Heart Circ Physiol. 2017 Sep 01;313(3):H620-H630

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory