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Kcnj4 Gene Detail
Summary
  • Symbol
    Kcnj4
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 4
  • Synonyms
    IRK3, Kcnf2, Kir 2.3, MB-IRK3
  • Feature Type
    protein coding gene
  • IDs
    MGI:104743
    NCBI Gene: 16520
  • Gene Overview
    MyGene.info: KCNJ4
Location & Maps
more
  • Sequence Map
    Chr15:79483718-79505241 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21524 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    KCNJ4, potassium voltage-gated channel subfamily J member 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KCNJ4, potassium voltage-gated channel subfamily J member 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HIR, HIRK2, HRK1, IRK3, IRK-3, Kir2.3
  • Links
    NCBI Gene ID: 3761
    neXtProt AC: NX_P48050

  • Chr Location
    22q13.1; chr22:38426327-38455199 (-)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    3 involving Kcnj4
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044216 Ensembl Gene Model | MGI Sequence Detail 21524 C57BL/6J ±  kb
transcript ENSMUST00000057801 Ensembl | MGI Sequence Detail 2148 Not Applicable  
polypeptide ENSMUSP00000094075 Ensembl | MGI Sequence Detail 445 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    127 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000002057 inward rectifier potassium channel 4
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR016449 Potassium channel, inwardly rectifying, Kir
    IPR003273 Potassium channel, inwardly rectifying, Kir2.3
    IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Molecular
Reagents
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  • All nucleic 19
    Genomic 7
    cDNA 10
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-16673, MGD-MRK-28034
References
more
  • Summaries
    All 42
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 5
    Phenotypes 21
  • Earliest
    J:18699 Morishige K, et al., Molecular cloning and functional expression of a novel brain-specific inward rectifier potassium channel. FEBS Lett. 1994 Jun 13;346(2-3):251-6
  • Latest
    J:209428 Ragancokova D, et al., TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction. J Clin Invest. 2014 Mar 3;124(3):1214-27

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory