Kcnj4
Gene Detail

Symbol Name ID

Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 MGI:104743

Synonyms

IRK3, Kcnf2, Kir 2.3, MB-IRK3

Feature Type

protein coding gene

Genetic Map

Chromosome 15

37.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr15:79483718-79505241 bp, - strand From Ensembl annotation of GRCm38   21524 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3653  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj4

Human homologs

Human Homolog		KCNJ4, potassium inwardly-rectifying channel, subfamily J, member 4
NCBI Gene ID		3761
neXtProt AC		NX_P48050
Human Synonyms		HIR, HIRK2, HRK1, IRK3, IRK-3, Kir2.3
Human Chr (Location)		22q13.1; chr22:38822332-38851205 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	ion transport, potassium ion transport, ...
Component	basolateral plasma membrane, cytoplasmic vesicle, ...
Function	inward rectifier potassium channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (92)    Tissues (45)    Images (2)
Theiler Stages: 23, 28

Assay Type	Results
RT-PCR	92

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(7) cDNA(10) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000044216 (Evidence)
Entrez Gene	16520 (Evidence)
UniGene	140760
DFCI	TC1584671
DoTS	DT.50315120
Consensus CDS Project	CCDS27641.1
International Mouse Knockout Project Status	Kcnj4

Sequences

Length	Strain/Species
genomic	ENSMUSG00000044216	Ensembl Gene Model | MGI Sequence Detail	21524	C57BL/6J
transcript	ENSMUST00000057801	Ensembl | MGI Sequence Detail	2148	Not Applicable
polypeptide	ENSMUSP00000094075	Ensembl | MGI Sequence Detail	445	Not Applicable

All sequences(22) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(117 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR016449	Potassium channel, inwardly rectifying, Kir
InterPro	IPR003273	Potassium channel, inwardly rectifying, Kir2.3
InterPro	IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology	PR:000002057	inward rectifier potassium channel 4

References

(Earliest) J:18699 Morishige K, et al., Molecular cloning and functional expression of a novel brain-specific inward rectifier potassium channel. FEBS Lett. 1994 Jun 13;346(2-3):251-6
(Latest) J:172665 Chinchilla A, et al., PITX2 Insufficiency Leads to Atrial Electrical and Structural Remodeling Linked to Arrhythmogenesis. Circ Cardiovasc Genet. 2011 Jun 1;4(3):269-79
All references(43)

Other accession IDs

MGD-MRK-16673, MGD-MRK-28034