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Kcnj4
Gene Detail
Symbol

Name
ID
Kcnj4
potassium inwardly-rectifying channel, subfamily J, member 4
MGI:104743
Synonyms
IRK3, Kcnf2, Kir 2.3, MB-IRK3
Feature Type
protein coding gene
Genetic Map
Chromosome 15
37.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr15:79483718-79505241 bp, - strand
From Ensembl annotation of GRCm38

  21524 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3653  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj4

Human
homologs
Human Homolog KCNJ4, potassium inwardly-rectifying channel, subfamily J, member 4
NCBI Gene ID 3761
neXtProt AC  NX_P48050
Human Synonyms  HIR, HIRK2, HRK1, IRK3, IRK-3, Kir2.3
Human Chr (Location)  22q13.1; chr22:38426327-38455199 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Radiation induced(1) Targeted(2)
Genomic Mutations involving Kcnj4 (1)
Incidental mutations (data from APF )
Interactions
Kcnj4 interacts with 104 markers (Mir1b, Mir25, Mir29c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process ion transport, potassium ion import, ...
Component basolateral plasma membrane, cell junction, ...
Function inward rectifier potassium channel activity, PDZ domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (92)    Tissues (45)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 92
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(7) cDNA(10) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000044216 (Evidence)
Entrez Gene16520 (Evidence)
UniGene140760
DFCITC1584671
DoTSDT.50315120
Consensus CDS ProjectCCDS27641.1
International Mouse Knockout Project StatusKcnj4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044216 Ensembl Gene Model | MGI Sequence Detail 21524 C57BL/6J ±  kb
transcript ENSMUST00000057801 Ensembl | MGI Sequence Detail 2148 Not Applicable 
polypeptide ENSMUSP00000094075 Ensembl | MGI Sequence Detail 445 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(9) UniProt(5)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(123 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR016449 Potassium channel, inwardly rectifying, Kir
InterPro IPR003273 Potassium channel, inwardly rectifying, Kir2.3
InterPro IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology PR:000002057 inward rectifier potassium channel 4
References
(Earliest) J:18699 Morishige K, et al., Molecular cloning and functional expression of a novel brain-specific inward rectifier potassium channel. FEBS Lett. 1994 Jun 13;346(2-3):251-6
(Latest) J:209428 Ragancokova D, et al., TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction. J Clin Invest. 2014 Mar 3;124(3):1214-27
All references(45)
Other
accession IDs
MGD-MRK-16673, MGD-MRK-28034

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory