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Kcnj3
Gene Detail
Symbol

Name
ID
Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
MGI:104742
Synonyms
GIRK1, Kcnf3, Kir3.1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
31.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:55435970-55598145 bp, + strand
From VEGA annotation of GRCm38

  162176 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1687  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj3

Human
homologs
Human Homolog KCNJ3, potassium inwardly-rectifying channel, subfamily J, member 3
NCBI Gene ID 3760
neXtProt AC  NX_P48549
Human Synonyms  GIRK1, KGA, KIR3.1
Human Chr (Location)  2q24.1; chr2:154698581-154858352 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation display slightly increased resting heart rates, and blunted responses to both indirect vagal activation and direct adenosine A1 receptor activation (intended to activate the muscarinic-gated atrial potassium channel).
 
Interactions
Kcnj3 interacts with 406 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (55)    Tissues (51)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
RT-PCR 49
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) Genomic(1) cDNA(8) Primer pair(3)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000015447 (Evidence)
Ensembl Gene ModelENSMUSG00000026824 (Evidence)
Entrez Gene16519 (Evidence)
DFCITC1697959, TC1597080, TC1588492
DoTSDT.91327197, DT.87049105, DT.91335983
NIA Mouse Gene IndexU001783
PDB3K6N, 2QKS, 1U4E, 1N9P
Consensus CDS ProjectCCDS16042.1
International Mouse Knockout Project StatusKcnj3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015447 VEGA Gene Model | MGI Sequence Detail 162176 C57BL/6J ±  kb
transcript OTTMUST00000036664 VEGA | MGI Sequence Detail 5215 Not Applicable 
polypeptide OTTMUSP00000016453 VEGA | MGI Sequence Detail 501 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(12) UniProt(5)
Polymorphisms
SNPs within 2kb(568 from dbSNP Build 137)    SNPs within 2kb including multiple locations(570)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR016449 Potassium channel, inwardly rectifying, Kir
InterPro IPR003274 Potassium channel, inwardly rectifying, Kir3.1
InterPro IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology PR:000002002 G protein-activated inward rectifier potassium channel 1
References
(Earliest) J:18699 Morishige K, et al., Molecular cloning and functional expression of a novel brain-specific inward rectifier potassium channel. FEBS Lett. 1994 Jun 13;346(2-3):251-6
(Latest) J:212259 Wydeven N, et al., Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10755-60
All references(57)
Other
accession IDs
MGD-MRK-16305, MGD-MRK-28033

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory