Kcnj3
Gene Detail

Symbol Name ID

Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 MGI:104742

Synonyms

GIRK1, Kcnf3, Kir3.1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

31.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:55435970-55598145 bp, + strand From VEGA annotation of GRCm38   162176 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1687  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj3

Human homologs

Human Homolog		KCNJ3, potassium inwardly-rectifying channel, subfamily J, member 3
NCBI Gene ID		3760
neXtProt AC		NX_P48549
Human Synonyms		GIRK1, KGA, KIR3.1
Human Chr (Location)		2q24.1; chr2:155555093-155714864 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Mice homozygous for a targeted null mutation display slightly increased resting heart rates, and blunted responses to both indirect vagal activation and direct adenosine A1 receptor activation (intended to activate the muscarinic-gated atrial potassium channel).

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	ion transport, potassium ion transport, ...
Component	cell surface, external side of plasma membrane, ...
Function	G-protein activated inward rectifier potassium channel activity, inward rectifier potassium channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (55)    Tissues (50)    Images (1)
Theiler Stages: 22, 23, 25, 28

Assay Type	Results
RNA in situ	6
RT-PCR	49

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) Genomic(1) cDNA(8) Primer pair(3)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000015447 (Evidence)
Ensembl Gene Model	ENSMUSG00000026824 (Evidence)
Entrez Gene	16519 (Evidence)
DFCI	TC1588492, TC1597080, TC1697959
DoTS	DT.87049105, DT.91327197, DT.91335983
NIA Mouse Gene Index	U001783
PDB	1N9P, 1U4E, 2QKS, 3K6N
Consensus CDS Project	CCDS16042.1
International Mouse Knockout Project Status	Kcnj3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015447	VEGA Gene Model | MGI Sequence Detail	162176	C57BL/6J
transcript	OTTMUST00000036664	VEGA | MGI Sequence Detail	5215	Not Applicable
polypeptide	OTTMUSP00000016453	VEGA | MGI Sequence Detail	501	Not Applicable

All sequences(37) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(460 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR016449	Potassium channel, inwardly rectifying, Kir
InterPro	IPR003274	Potassium channel, inwardly rectifying, Kir3.1
InterPro	IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology	PR:000002002	G protein-activated inward rectifier potassium channel 1

References

(Earliest) J:18699 Morishige K, et al., Molecular cloning and functional expression of a novel brain-specific inward rectifier potassium channel. FEBS Lett. 1994 Jun 13;346(2-3):251-6
(Latest) J:193179 Wydeven N, et al., Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21492-7
All references(55)

Other accession IDs

MGD-MRK-16305, MGD-MRK-28033