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Kcnj3
Gene Detail
 Symbol
Name
ID
Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
MGI:104742
Synonyms GIRK1, Kcnf3, Kir3.1
Feature Type protein coding gene
Genetic Map
Chromosome 2
31.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:55435970-55598145 bp, + strand
From VEGA annotation of GRCm38

  162176 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1687  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj3

Human
homologs
Human Homolog KCNJ3, potassium inwardly-rectifying channel, subfamily J, member 3
NCBI Gene ID 3760
neXtProt AC  NX_P48549
Human Synonyms  GIRK1, KGA, KIR3.1
Human Chr (Location)  2q24.1; chr2:154698581-154858352 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(3) Gene trapped(2)
 
Mice homozygous for a targeted null mutation display slightly increased resting heart rates, and blunted responses to both indirect vagal activation and direct adenosine A1 receptor activation (intended to activate the muscarinic-gated atrial potassium channel).
 
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component cell surface, external side of plasma membrane, ...
Function G-protein activated inward rectifier potassium channel activity, inward rectifier potassium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (55)    Tissues (50)    Images (1)
Theiler Stages: 22, 23, 25, 28
Assay TypeResults
RNA in situ 6
RT-PCR 49
cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(12) Genomic(1) cDNA(8) Primer pair(3)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000015447 (Evidence)
Ensembl Gene ModelENSMUSG00000026824 (Evidence)
Entrez Gene16519 (Evidence)
DFCITC1588492, TC1597080, TC1697959
DoTSDT.87049105, DT.91327197, DT.91335983
NIA Mouse Gene IndexU001783
PDB1N9P, 1U4E, 2QKS, 3K6N
Consensus CDS ProjectCCDS16042.1
International Mouse Knockout Project StatusKcnj3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015447 VEGA Gene Model | MGI Sequence Detail 162176 C57BL/6J ±  kb
transcript OTTMUST00000036664 VEGA | MGI Sequence Detail 5215 Not Applicable 
polypeptide OTTMUSP00000016453 VEGA | MGI Sequence Detail 501 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(12) UniProt(3)
Polymorphisms SNPs within 2kb(568 from dbSNP Build 137)    SNPs within 2kb including multiple locations(570)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR016449 Potassium channel, inwardly rectifying, Kir
InterPro IPR003274 Potassium channel, inwardly rectifying, Kir3.1
InterPro IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology PR:000002002 G protein-activated inward rectifier potassium channel 1
References (Earliest) J:18699 Morishige K, et al., Molecular cloning and functional expression of a novel brain-specific inward rectifier potassium channel. FEBS Lett. 1994 Jun 13;346(2-3):251-6
(Latest) J:193179 Wydeven N, et al., Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21492-7
All references(55)
Other
accession IDs
MGD-MRK-16305, MGD-MRK-28033

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory