Gt(ROSA)26Sor Gene Detail

Summary

• Symbol
  Gt(ROSA)26Sor
• Name
  gene trap ROSA 26, Philippe Soriano
• Synonyms
  beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1

• Feature Type
  lncRNA gene
• IDs
  MGI:104735
  NCBI Gene: 14910
• Alliance
  genome feature page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr6:113044389-113054205 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 6, 52.73 cM
• Mapping Data
  5 experiments

Strain
Comparison

• SNPs within 2kb
  191 from dbSNP Build 142
• Strain Annotations
  19
• RFLP
  1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104735	lncRNA gene	Chr6:113043843-113055336 (-)
129S1/SvImJ	ENSMUSG00200026343	lncRNA gene	Chr6:110093556-110104007 (-)
A/J	ENSMUSG00195017634	lncRNA gene	Chr6:109765984-109776437 (-)
AKR/J	ENSMUSG00220037462	lncRNA gene	Chr6:108689306-108699753 (-)
BALB/cJ	ENSMUSG00180002409	lncRNA gene	Chr6:110130718-110141170 (-)
C3H/HeJ	ENSMUSG00175034470	lncRNA gene	Chr6:67267291-67277738 (+)
C57BL/6NJ	ENSMUSG00215023071	lncRNA gene	Chr6:110125183-110135635 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0003916	antisense lncRNA gene	Chr6:108147135-108157094 (-)
CAST/EiJ	ENSTCUG00005030839	lncRNA gene	Chr6:109936342-109946798 (-)
CBA/J	ENSMUSG00210020641	lncRNA gene	Chr6:109949228-109959675 (-)
DBA/2J	ENSMUSG00185019103	lncRNA gene	Chr6:110324744-110335184 (-)
FVB/NJ	ENSMUSG00205029584	lncRNA gene	Chr6:109024614-109035040 (-)
JF1/MsJ	ENSUMUG00000030334	lncRNA gene	Chr6:109053959-109064419 (-)
LP/J	ENSMUSG00230049506	lncRNA gene	Chr6:111594894-111605345 (-)
NOD/ShiLtJ	ENSMUSG00190018979	lncRNA gene	Chr6:109523423-109533850 (-)
NZO/HlLtJ	ENSMUSG00225048443	lncRNA gene	Chr6:113539037-113549477 (-)
PWK/PhJ	ENSLUMG00010029547	lncRNA gene	Chr6:108546358-108556825 (-)
SPRET/EiJ	ENSMSPG00010046366	lncRNA gene	Chr6:111324195-111334609 (-)
WSB/EiJ	ENSIUOG00005026206	lncRNA gene	Chr6:110277398-110287849 (-)

Homology

• Human Ortholog
  THUMPD3-AS1, THUMPD3 antisense RNA 1

• Vertebrate Orthologs
  1

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  THUMPD3-AS1, THUMPD3 antisense RNA 1
  
• Synonyms
  SETD5-AS1
• Links
  HGNC:44478

  NCBI Gene ID: 440944

  
  
• Chr Location
  3p25.3; chr3:9349689-9398625 (-)  GRCh38

---

• MGI Vertebrate Homology
  Gt(ROSA)26Sor stringent orthology
  1 human;1 mouse
  
• HCOP
  vertebrate homology predictions: THUMPD3-AS1
• Gene Tree
  Gt(ROSA)26Sor
  

Human Diseases

• Mutations/Alleles
  74 with disease annotations

• References
  98 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2200 phenotypes from multigenic genotypes
  92 images
  26245 phenotype references
  

• All Mutations and Alleles
  2035
• Endonuclease-mediated
  480
• Gene trapped
  176
• Spontaneous
  1
• Targeted
  1377
• Genomic Mutations
  1 involving Gt(ROSA)26Sor
• Find Mice (IMSR)
  1209 strains or lines available
• Recombinase Activity
  Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for the original gene trap insertion and a targeted mutation mimicking the original gene trap exhibit no abnormal phenotype.

Expression

• Assay Results
  630
• Tissues
  13
• cDNA Data
  42
• Literature Summary
  16

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  58
• RefSeq
  3

• Ensembl
  ENSMUSG00000086429 (Evidence)
• NCBI Gene
  14910

Representative Sequences			Length	Strain/Species
genomic	14910	NCBI Gene Model | MGI Sequence Detail	9817	C57BL/6J
transcript	NR_027008	RefSeq | MGI Sequence Detail	1230	ZRU/MplStud

Molecular
Reagents

• All nucleic 48

  Genomic 3

  cDNA 43

  Primer pair 2

  
  

  Microarray probesets 2

Other
Accession IDs

MGD-MRK-27098, MGI:2141626

References

• Summaries
  All 26360

  Developmental Gene Expression 16

  Diseases 98

  Phenotypes 26245
• Earliest
  J:12736 Hayasaka I, et al., Polydactyly Nagoya, Pdn: A new mutant gene in the mouse. Jikken Dobutsu. 1980 Oct;29(4):391-5
• Latest
  J:391828 De Stefano MA, et al., Type 2 deiodinase-dependent surge in thyroid hormone controls muscle stem cell quiescence and self-renewal. J Clin Invest. 2026 May 1;136(9)

TSS for Gt(ROSA)26Sor:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr62430	Chr6:113054198-113054211 (-)	0 bp
Tssr62429	Chr6:113054142-113054164 (-)	52 bp
Tssr62428	Chr6:113053278-113053288 (-)	922 bp