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Adam5 Gene Detail
Summary
  • Symbol
    Adam5
  • Name
    a disintegrin and metallopeptidase domain 5
  • Synonyms
    tMDCII
  • Feature Type
    protein coding gene
  • IDs
    MGI:104730
    NCBI Gene: 11499
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:24727093-24824369 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      97277 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 13.26 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ADAM5, ADAM metallopeptidase domain 5 (pseudogene)
  • Vertebrate Orthologs
    4
  • Human Ortholog
    ADAM5, ADAM metallopeptidase domain 5 (pseudogene)
    Orthology source: HGNC
  • Synonyms
    ADAM5P, TMDCII
  • Links
    NCBI Gene ID: 255926
    neXtProt AC: NX_Q6NVV9
    UniProt: Q6NVV9

  • Chr Location
    8p11.22; chr8:39314663-39417226 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031764 VEGA Gene Model | MGI Sequence Detail 97277 C57BL/6J ±  kb
transcript OTTMUST00000078694 VEGA | MGI Sequence Detail 2560 Not Applicable  
polypeptide OTTMUSP00000041881 VEGA | MGI Sequence Detail 771 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    132 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 24
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-27093
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:17855 Ballock RT, et al., Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta. J Cell Physiol. 1994 May;159(2):340-6
  • Latest
    J:208737 Li W, et al., Tex101 is essential for male fertility by affecting sperm migration into the oviduct in mice. J Mol Cell Biol. 2013 Oct;5(5):345-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory