Adam5 MGI Mouse Gene Detail - MGI:104730 - a disintegrin and metallopeptidase domain 5

Symbol

Adam5
Name

a disintegrin and metallopeptidase domain 5
Synonyms

tMDCII

Feature Type

protein coding gene
IDs

MGI:104730
NCBI Gene: 11499
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr8:25217109-25314385 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 13.26 cM
Mapping Data

3 experiments

SNPs within 2kb

132 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104730	protein coding gene	Chr8:25217109-25314385 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033474	protein coding gene	Chr8:22731755-22808311 (-)
A/J	MGP_AJ_G0033454	protein coding gene	Chr8:21935959-22017163 (-)
AKR/J	MGP_AKRJ_G0033379	protein coding gene	Chr8:22659571-22733588 (-)
BALB/cJ	MGP_BALBcJ_G0033450	protein coding gene	Chr8:22088927-22165063 (-)
C3H/HeJ	MGP_C3HHeJ_G0033164	protein coding gene	Chr8:22850942-22933910 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033966	protein coding gene	Chr8:23634644-23743000 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030916	protein coding gene	Chr8:19243726-19313420 (-)
CAST/EiJ	MGP_CASTEiJ_G0032490	protein coding gene	Chr8:22275419-22357437 (-)
CBA/J	MGP_CBAJ_G0033139	protein coding gene	Chr8:24584674-24669613 (-)
DBA/2J	MGP_DBA2J_G0033294	protein coding gene	Chr8:21903784-21992598 (-)
FVB/NJ	MGP_FVBNJ_G0033238	protein coding gene	Chr8:21690534-21784364 (-)
LP/J	MGP_LPJ_G0033383	protein coding gene	Chr8:22722762-22801155 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033281	protein coding gene	Chr8:24103636-24194450 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033985	protein coding gene	Chr8:22577220-22667403 (-)
PWK/PhJ	MGP_PWKPhJ_G0032201	protein coding gene	Chr8:21510071-21586585 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032035	protein coding gene	Chr8:21940055-22016351 (-)
WSB/EiJ	MGP_WSBEiJ_G0032606	protein coding gene	Chr8:22802419-22867762 (-)

Human Ortholog

ADAM5, ADAM metallopeptidase domain 5 (pseudogene)

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADAM5, ADAM metallopeptidase domain 5 (pseudogene)
Synonyms

ADAM5P, TMDCII
Links

HGNC:212

NCBI Gene ID: 255926

UniProt: Q6NVV9
Chr Location

8p11.22; chr8:39314591-39417378 (+) GRCh38

MGI Vertebrate Homology

Adam5 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ADAM5
Gene Tree

Adam5

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

3
Gene trapped

1
Targeted

7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

57 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

22
cDNA Data

25
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

58
RefSeq

12
UniProt

5
CCDS

CCDS52525.1, CCDS72107.1, CCDS85515.1

Ensembl

ENSMUSG00000031554 (Evidence)
NCBI Gene

11499

			Length	Strain/Species	Flank
genomic	11499	NCBI Gene Model \| MGI Sequence Detail	97277	C57BL/6J	± kb
transcript	NM_001272058	RefSeq \| MGI Sequence Detail	2956	ZRU/MplStud
polypeptide	Q3TTE0	UniProt \| EBI \| MGI Sequence Detail	751	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004554 disintegrin and metalloproteinase domain-containing protein 5

(term hierarchy)
InterPro Domains

IPR006586 ADAM, cysteine-rich domain

IPR018358 Disintegrin, conserved site

IPR001762 Disintegrin domain

IPR036436 Disintegrin domain superfamily

IPR000742 EGF-like domain

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR001590 Peptidase M12B, ADAM/reprolysin

IPR002870 Peptidase M12B, propeptide

IPR034027 Reprolysin domain, adamalysin-type

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All nucleic 26

cDNA 25

Primer pair 1

Microarray probesets 5

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MGD-MRK-27093

Summaries

All 35

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 8
Earliest

J:17855 Ballock RT, et al., Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta. J Cell Physiol. 1994 May;159(2):340-6
Latest

J:208737 Li W, et al., Tex101 is essential for male fertility by affecting sperm migration into the oviduct in mice. J Mol Cell Biol. 2013 Oct;5(5):345-7

TSS for Adam5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr80656	Chr8:25314065-25314075 (-)	315 bp
Tssr80655	Chr8:25314032-25314061 (-)	338 bp
Tssr2522	Chr8:25313995-25314002 (-)	386 bp
Tssr2521	Chr8:25313990-25313994 (-)	393 bp
Tssr80654	Chr8:25308563-25308572 (-)	5,817 bp
Tssr80653	Chr8:25308543-25308552 (-)	5,837 bp
Tssr80652	Chr8:25304134-25304142 (-)	10,247 bp
Tssr80651	Chr8:25304111-25304120 (-)	10,269 bp
Tssr80650	Chr8:25236778-25236792 (-)	77,600 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23