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Adam5 Gene Detail
Summary
  • Symbol
    Adam5
  • Name
    a disintegrin and metallopeptidase domain 5
  • Synonyms
    tMDCII
  • Feature Type
    protein coding gene
  • IDs
    MGI:104730
    NCBI Gene: 11499
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:24727093-24824369 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 13.26 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104730
protein coding gene Chr8:24727093-24824369 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033474
protein coding gene Chr8:22731755-22808311 (-)
A/J MGP_AJ_G0033454
protein coding gene Chr8:21935959-22017163 (-)
AKR/J MGP_AKRJ_G0033379
protein coding gene Chr8:22659571-22733588 (-)
BALB/cJ MGP_BALBcJ_G0033450
protein coding gene Chr8:22088927-22165063 (-)
C3H/HeJ MGP_C3HHeJ_G0033164
protein coding gene Chr8:22850942-22933910 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033966
protein coding gene Chr8:23634644-23743000 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030916
protein coding gene Chr8:19243726-19313420 (-)
CAST/EiJ MGP_CASTEiJ_G0032490
protein coding gene Chr8:22275419-22357437 (-)
CBA/J MGP_CBAJ_G0033139
protein coding gene Chr8:24584674-24669613 (-)
DBA/2J MGP_DBA2J_G0033294
protein coding gene Chr8:21903784-21992598 (-)
FVB/NJ MGP_FVBNJ_G0033238
protein coding gene Chr8:21690534-21784364 (-)
LP/J MGP_LPJ_G0033383
protein coding gene Chr8:22722762-22801155 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033281
protein coding gene Chr8:24103636-24194450 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033985
protein coding gene Chr8:22577220-22667403 (-)
PWK/PhJ MGP_PWKPhJ_G0032201
protein coding gene Chr8:21510071-21586585 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032035
protein coding gene Chr8:21940055-22016351 (-)
WSB/EiJ MGP_WSBEiJ_G0032606
protein coding gene Chr8:22802419-22867762 (-)



Homology
more
  • Human Ortholog
    ADAM5, ADAM metallopeptidase domain 5 (pseudogene)
  • Vertebrate Orthologs
    4
  • Human Ortholog
    ADAM5, ADAM metallopeptidase domain 5 (pseudogene)
    Orthology source: HGNC
  • Synonyms
    ADAM5P, TMDCII
  • Links
    NCBI Gene ID: 255926
    UniProt: Q6NVV9

  • Chr Location
    8p11.22; chr8:39314663-39417226 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 11499 NCBI Gene Model | MGI Sequence Detail 97277 C57BL/6J ±  kb
transcript NM_001272058 RefSeq | MGI Sequence Detail 2956 C57BL/6  
polypeptide Q3TTE0 UniProt | EBI | MGI Sequence Detail 751 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 25
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-27093
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:17855 Ballock RT, et al., Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta. J Cell Physiol. 1994 May;159(2):340-6
  • Latest
    J:208737 Li W, et al., Tex101 is essential for male fertility by affecting sperm migration into the oviduct in mice. J Mol Cell Biol. 2013 Oct;5(5):345-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory