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Caml Gene Detail
Summary
  • Symbol
    Caml
  • Name
    calcium modulating ligand
  • Synonyms
    Caml
  • Feature Type
    protein coding gene
  • IDs
    MGI:104728
    NCBI Gene: 12328
  • Gene Overview
    MyGene.info: CAMLG
Location & Maps
more
  • Sequence Map
    Chr13:55623005-55632411 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9407 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 30.06 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    CAMLG, calcium modulating ligand
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CAMLG, calcium modulating ligand
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAML, GET2
  • Links
    NCBI Gene ID: 819
    neXtProt AC: NX_P49069

  • Chr Location
    5q23; chr5:134737927-134752160 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Targeted
    4
  • Genomic Mutations
    1 involving Caml
  • Incidental Mutations
Mice lacking both functional copies of this gene die during early gestation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035499 VEGA Gene Model | MGI Sequence Detail 9407 C57BL/6J ±  kb
transcript OTTMUST00000090902 VEGA | MGI Sequence Detail 1382 Not Applicable  
polypeptide OTTMUSP00000049991 VEGA | MGI Sequence Detail 294 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    80 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000004997 calcium signal-modulating cyclophilin ligand
  • InterPro Domains
    IPR016719 Calcium signal-modulating cyclophilin ligand
Molecular
Reagents
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  • All nucleic 51
    cDNA 51

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-27091, MGI:2145224
References
more
  • Summaries
    All 43
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:29210 Kim HS, et al., Cloning of the gene encoding the mouse homologue of the human calcium signal-modulating ligand. Gene. 1995 Oct 3;163(2):323-4
  • Latest
    J:183110 Zane NA, et al., Essential role for CAML in follicular B cell survival and homeostasis. J Immunol. 2012 Apr 1;188(7):3009-18

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory