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Cplx1
Gene Detail
Symbol

Name
ID
Cplx1
complexin 1
MGI:104727
Synonyms
921-S
Feature Type
protein coding gene
Genetic Map
Chromosome 5
53.17 cM
Detailed Genetic Map ± 1 cM

Sequence Map
Chr5:108518554-108550024 bp, - strand
From VEGA annotation of GRCm38

  31471 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21324  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CPLX1
Gene Tree: Cplx1

Human
homologs
CPLX1, complexin 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10815
neXtProt AC: NX_O14810

Human Synonyms: CPX1, CPX-I

Human Chr (Location): 4p16.3; chr4:784957-826157 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
 
Mice homozygous for disruptions of this gene suffer from ataxia, are unable to reproduce, and die within 2-4 months of age.
 
Interactions
Cplx1 interacts with 171 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process exocytosis, insulin secretion, ...
Component cell, cytoplasm, ...
Function neurotransmitter transporter activity, SNARE binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (253)    Tissues (55)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 253
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cplx1    NEW 
Molecular
reagents
All nucleic(30) Genomic(1) cDNA(29)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000028893 (Evidence)
Ensembl Gene Model ENSMUSG00000033615 (Evidence)
Entrez Gene 12889 (Evidence)
UniGene 5195
DFCI TC1574668
DoTS DT.101192537, DT.55100555
NIA Mouse Gene Index U026530
Consensus CDS Project CCDS39206.1
International Mouse Phenotyping Consortium Status Cplx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028893 VEGA Gene Model | MGI Sequence Detail 31471 C57BL/6J ±  kb
transcript OTTMUST00000071597 VEGA | MGI Sequence Detail 2189 Not Applicable 
polypeptide OTTMUSP00000036724 VEGA | MGI Sequence Detail 134 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(281 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008849 Synaphin
Protein Ontology PR:000005809 complexin-1
References
(Earliest) J:29256 McMahon HT, et al., Complexins: cytosolic proteins that regulate SNAP receptor function. Cell. 1995 Oct 6;83(1):111-9
(Latest) J:222237 Chang S, et al., Complexin stabilizes newly primed synaptic vesicles and prevents their premature fusion at the mouse calyx of held synapse. J Neurosci. 2015 May 27;35(21):8272-90
All references(52)
Other
accession IDs
MGD-MRK-27090

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory