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Cplx1 Gene Detail
Summary
  • Symbol
    Cplx1
  • Name
    complexin 1
  • Synonyms
    921-S
  • Feature Type
    protein coding gene
  • IDs
    MGI:104727
    NCBI Gene: 12889
  • Gene Overview
    MyGene.info: CPLX1
Location & Maps
more
  • Sequence Map
    Chr5:108518554-108550024 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31471 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 53.17 cM
Homology
more
  • Human Ortholog
    CPLX1, complexin 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CPLX1, complexin 1
    Orthology source: HomoloGene
  • Synonyms
    CPX1, CPX-I
  • Links
    NCBI Gene ID: 10815
    neXtProt AC: NX_O14810

  • Chr Location
    4p16.3; chr4:784957-826157 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CPLX1 associations

Human Disease Mouse Models
       Wolf-Hirschhorn Syndrome; WHS   OMIM: 194190
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Cplx1
Mice homozygous for disruptions of this gene suffer from ataxia, are unable to reproduce, and die within 2-4 months of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028893 VEGA Gene Model | MGI Sequence Detail 31471 C57BL/6J ±  kb
transcript OTTMUST00000071597 VEGA | MGI Sequence Detail 2189 Not Applicable  
polypeptide OTTMUSP00000036724 VEGA | MGI Sequence Detail 134 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    281 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    Genomic 1
    cDNA 29

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-27090
References
more
  • Summaries
    All 50
    Developmental Gene Expression 8
    Gene Ontology 5
    Phenotypes 24
  • Earliest
    J:29256 McMahon HT, et al., Complexins: cytosolic proteins that regulate SNAP receptor function. Cell. 1995 Oct 6;83(1):111-9
  • Latest
    J:222237 Chang S, et al., Complexin stabilizes newly primed synaptic vesicles and prevents their premature fusion at the mouse calyx of held synapse. J Neurosci. 2015 May 27;35(21):8272-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory