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Cplx1
Gene Detail
 Symbol
Name
ID
Cplx1
complexin 1
MGI:104727
Synonyms 921-S
Feature Type protein coding gene
Genetic Map
Chromosome 5
53.17 cM
Detailed Genetic Map ± 1 cM

Sequence Map
Chr5:108518554-108550024 bp, - strand
From VEGA annotation of GRCm38

  31471 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21324  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cplx1

Human
homologs
Human Homolog CPLX1, complexin 1
NCBI Gene ID 10815
neXtProt AC  NX_O14810
Human Synonyms  CPX1, CPX-I
Human Chr (Location)  4p16.3; chr4:784957-826157 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
 
Mice homozygous for disruptions of this gene suffer from ataxia, are unable to reproduce, and die within 2-4 months of age.
 
Interactions
Cplx1 interacts with 171 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process exocytosis, insulin secretion, ...
Component cell, cytoplasm, ...
Function neurotransmitter transporter activity, SNARE binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (253)    Tissues (55)    Images (52)
Theiler Stages: 19, 23, 27, 28
Assay TypeResults
RNA in situ 253
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(1) cDNA(29)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000028893 (Evidence)
Ensembl Gene ModelENSMUSG00000033615 (Evidence)
Entrez Gene12889 (Evidence)
UniGene5195
DFCITC1574668
DoTSDT.101192537, DT.55100555
NIA Mouse Gene IndexU026530
Consensus CDS ProjectCCDS39206.1
International Mouse Knockout Project StatusCplx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028893 VEGA Gene Model | MGI Sequence Detail 31471 C57BL/6J ±  kb
transcript OTTMUST00000071597 VEGA | MGI Sequence Detail 2189 Not Applicable 
polypeptide OTTMUSP00000036724 VEGA | MGI Sequence Detail 134 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(281 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008849 Synaphin
Protein Ontology PR:000005809 complexin-1
References (Earliest) J:29256 McMahon HT, et al., Complexins: cytosolic proteins that regulate SNAP receptor function. Cell. 1995 Oct 6;83(1):111-9
(Latest) J:210580 Lin MY, et al., Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems. J Physiol. 2013 May 15;591(Pt 10):2463-73
All references(52)
Other
accession IDs
MGD-MRK-27090

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory