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Hsd11b2
Gene Detail
 Symbol
Name
ID
Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
MGI:104720
Synonyms 11(beta)-HSD2, 11HSD2
Feature Type protein coding gene
Genetic Map
Chromosome 8
53.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:105518746-105523984 bp, + strand
From Ensembl annotation of GRCm38

  5239 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20088  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

Protein SuperFamily: retinol dehydrogenase
Gene Tree: Hsd11b2

Human
homologs
Human Homolog HSD11B2, hydroxysteroid (11-beta) dehydrogenase 2
NCBI Gene ID 3291
neXtProt AC  NX_P80365
Human Synonyms  AME, AME1, HSD11K, HSD2, SDR9C3
Human Chr (Location)  16q22; chr16:67431133-67437553 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HSD11B2
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
About half of all mice homozygous for disruptions in this gene die within 48 hours of birth. Survivors are subject to sudden unexplained deaths when between 2 and 4 months of age. They are hypertensive with dilute urine and are hypokalemic and hypochloremic.
 
Human Diseases Modeled Using Mouse Hsd11b2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process glucocorticoid metabolic process, metabolic process, ...
Component cytoplasm, endoplasmic reticulum, ...
Function 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity, 2-hydroxytetrahydrofuran dehydrogenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (196)    Tissues (114)    Images (25)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 186
RT-PCR 10
cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(34) Genomic(1) cDNA(32) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031891 (Evidence)
Entrez Gene15484 (Evidence)
UniGene5079
DFCITC1579884, TC1775557
DoTSDT.102555316, DT.60108886
NIA Mouse Gene IndexU009748
EC1.1.1.-
Consensus CDS ProjectCCDS40460.1
International Mouse Knockout Project StatusHsd11b2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031891 Ensembl Gene Model | MGI Sequence Detail 5239 C57BL/6J ±  kb
transcript ENSMUST00000034363 Ensembl | MGI Sequence Detail 1845 Not Applicable 
polypeptide ENSMUSP00000034363 Ensembl | MGI Sequence Detail 386 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000008772 corticosteroid 11-beta-dehydrogenase isozyme 2
References (Earliest) J:29215 Cole TJ, Cloning of the mouse 11 beta-hydroxysteroid dehydrogenase type 2 gene: tissue specific expression and localization in distal convoluted tubules and collecting ducts of the kidney. Endocrinology. 1995 Oct;136(10):4693-6
(Latest) J:205456 Jiang L, et al., Epithelial-specific deletion of 11beta-HSD2 hinders Apcmin/+ mouse tumorigenesis. Mol Cancer Res. 2013 Sep;11(9):1040-50
All references(56)
Other
accession IDs
MGD-MRK-27083

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory