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Wbp2 Gene Detail
Summary
  • Symbol
    Wbp2
  • Name
    WW domain binding protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104709
    NCBI Gene: 22378
  • Gene Overview
    MyGene.info: WBP2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:116078573-116086995 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8423 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 80.91 cM, cytoband E2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    WBP2, WW domain binding protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WBP2, WW domain binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DFNB107, GRAMD6, WBP-2
  • Links
    NCBI Gene ID: 23558
    neXtProt AC: NX_Q969T9
    UniProt: Q969T9

  • Chr Location
    17q25.1; chr17:75845699-75855420 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32160
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: WBP2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human WBP2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show progressive high-frequency hearing loss, raised auditory brainstem response (ABR) thresholds, reduced ABR amplitudes, swelling of afferent terminals, inner hair cell synapse defects, and altered expression of AMPA receptor subunits and post-synaptic proteins.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000003690 VEGA Gene Model | MGI Sequence Detail 8423 C57BL/6J ±  kb
    transcript OTTMUST00000008000 VEGA | MGI Sequence Detail 1826 Not Applicable  
    polypeptide OTTMUSP00000003889 VEGA | MGI Sequence Detail 261 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      29 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 224
      cDNA 224

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-27072
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 3
      Gene Ontology 2
      Phenotypes 13
    • Earliest
      J:27757 Sudol M, et al., Characterization of a novel protein-binding module--the WW domain. FEBS Lett. 1995 Aug 1;369(1):67-71
    • Latest
      J:241362 Walko G, et al., A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells. Nat Commun. 2017 Mar 23;8:14744

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory