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Wbp2 Gene Detail
Summary
  • Symbol
    Wbp2
  • Name
    WW domain binding protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104709
    NCBI Gene: 22378
  • Gene Overview
    MyGene.info: WBP2
Location & Maps
more
  • Sequence Map
    Chr11:116078573-116086995 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8423 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 80.91 cM, cytoband E2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    WBP2, WW domain binding protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WBP2, WW domain binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GRAMD6, WBP-2
  • Links
    NCBI Gene ID: 23558
    neXtProt AC: NX_Q969T9

  • Chr Location
    17q25.1; chr17:75845699-75855420 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 32160
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: WBP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003690 VEGA Gene Model | MGI Sequence Detail 8423 C57BL/6J ±  kb
transcript OTTMUST00000008000 VEGA | MGI Sequence Detail 1826 Not Applicable  
polypeptide OTTMUSP00000003889 VEGA | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    29 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 224
    cDNA 224

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-27072
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 12
  • Earliest
    J:27757 Sudol M, et al., Characterization of a novel protein-binding module--the WW domain. FEBS Lett. 1995 Aug 1;369(1):67-71
  • Latest
    J:229594 Buniello A, et al., Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing. EMBO Mol Med. 2016;8(3):191-207

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory