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Cct3 Gene Detail
Summary
  • Symbol
    Cct3
  • Name
    chaperonin containing Tcp1, subunit 3 (gamma)
  • Synonyms
    Cctg, Tcp1-rs3, TriC-P5
  • Feature Type
    protein coding gene
  • IDs
    MGI:104708
    NCBI Gene: 12462
  • Gene Overview
    MyGene.info: CCT3
Location & Maps
more
  • Sequence Map
    Chr3:88297116-88321767 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24652 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.79 cM, cytoband F
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    CCT3, chaperonin containing TCP1 subunit 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CCT3, chaperonin containing TCP1 subunit 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CCTG, CCT-gamma, PIG48, TCP-1-gamma, TRIC5
  • Links
    NCBI Gene ID: 7203
    neXtProt AC: NX_P49368

  • Chr Location
    1q23; chr1:156308961-156338415 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4373
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CCT3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from multigenic genotypes
    9 phenotype references
  • All Mutations and Alleles
    56
  • Chemically induced (other)
    1
  • Gene trapped
    53
  • Radiation induced
    1
  • Transgenic
    1
  • Genomic Mutations
    2 involving Cct3
  • Incidental Mutations
Mice homozygous for a transgenic gene disruption may exhibit lethality at E8.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035166 VEGA Gene Model | MGI Sequence Detail 24652 C57BL/6J ±  kb
transcript OTTMUST00000089567 VEGA | MGI Sequence Detail 1977 Not Applicable  
polypeptide OTTMUSP00000048968 VEGA | MGI Sequence Detail 545 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    39 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000005151 T-complex protein 1 subunit gamma
  • PDB
  • InterPro Domains
    IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
    IPR002423 Chaperonin Cpn60/TCP-1 family
    IPR002194 Chaperonin TCP-1, conserved site
    IPR027409 GroEL-like apical domain
    IPR027413 GroEL-like equatorial domain
    IPR012719 T-complex protein 1, gamma subunit
    IPR027410 TCP-1-like chaperonin intermediate domain
Molecular
Reagents
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  • All nucleic 647
    Genomic 1
    cDNA 644
    Primer pair 1
    Other 1

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-16724, MGD-MRK-27071, MGI:2144350
References
more
  • Summaries
    All 50
    Developmental Gene Expression 2
    Gene Ontology 12
    Phenotypes 9
  • Earliest
    J:17100 Joly EC, et al., cDNA encoding a novel TCP1-related protein. Biochim Biophys Acta. 1994 Mar 1;1217(2):224-6
  • Latest
    J:224715 Joachimiak LA, et al., The structural basis of substrate recognition by the eukaryotic chaperonin TRiC/CCT. Cell. 2014 Nov 20;159(5):1042-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory