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Lim2
Gene Detail
 Symbol
Name
ID
Lim2
lens intrinsic membrane protein 2
MGI:104698
Synonyms 19kDa, MP19
Feature Type protein coding gene
Genetic Map
Chromosome 7
28.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr7:43430101-43435991 bp, + strand
From NCBI annotation of GRCm38

  5891 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12744  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 2 zebrafish

Protein SuperFamily: peripheral myelin protein 22/epithelial membrane protein

Human
homologs
Human Homolog LIM2, lens intrinsic membrane protein 2, 19kDa
NCBI Gene ID 3982
neXtProt AC  NX_P55344
Human Synonyms  CTRCT19, MP17, MP19
Human Chr (Location)  19q13.4; chr19:51379909-51387956 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human LIM2
Alleles
and
phenotypes
All alleles(6) : Targeted(1) Gene trapped(3) Chemically induced(2)
 
Homozygous mutants exhibit microphthalmia, total lens opacity, disorganized lens fibers, posterior rupturing of lens capsule, and some have vacuolated lens. Heterozygotes exhibit the same dense cataract, but without microphthalmia or lens rupture.
 
Human Diseases Modeled Using Mouse Lim2 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process camera-type eye development, lens development in camera-type eye
Component integral component of membrane, membrane, ...
Function structural constituent of eye lens
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (2)    Tissues (1)    Images (2)
Theiler Stages: 23
Assay TypeResults
RNA in situ 2
cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(10) Genomic(2) cDNA(8)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000039806 (Evidence), OTTMUSG00000042533 (Evidence), OTTMUSG00000039804 (Evidence)
Ensembl Gene ModelENSMUSG00000004613 (Evidence), ENSMUSG00000093639 (Evidence), ENSMUSG00000097437 (Evidence)
Entrez Gene233187 (Evidence)
UniGene267027
DFCITC1585659
DoTSDT.483866, DT.94172483
NIA Mouse Gene IndexU008012
Consensus CDS ProjectCCDS21168.1
International Mouse Knockout Project StatusLim2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 233187 NCBI Gene Model | MGI Sequence Detail 5891 C57BL/6J ±  kb
transcript NM_177693 RefSeq | MGI Sequence Detail 866 C57BL/6 
polypeptide H3BKT1 UniProt | EBI | MGI Sequence Detail 185 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(4)
Polymorphisms RFLP(4) : SNPs within 2kb(89 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003935 Lens fibre membrane intrinsic protein
InterPro IPR004032 PMP-22/EMP/MP20
InterPro IPR004031 PMP-22/EMP/MP20/Claudin
Protein Ontology PR:000009813 lens fiber membrane intrinsic protein
Graphical View of Protein Domain Structure
References (Earliest) J:23988 Ehling UH, et al., Dominant cataract mutations and specific-locus mutations in mice induced by radiation or ethylnitrosourea. Mutat Res. 1982 Feb 22;92(1-2):181-92
(Latest) J:181598 Shi Y, et al., Further analysis of the lens phenotype in Lim2-deficient mice. Invest Ophthalmol Vis Sci. 2011 Sep;52(10):7332-9
All references(44)
Other
accession IDs
MGD-MRK-27061, MGD-MRK-36104, MGI:107534

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory