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Lim2 Gene Detail
Summary
  • Symbol
    Lim2
  • Name
    lens intrinsic membrane protein 2
  • Synonyms
    19kDa, MP19
  • Feature Type
    protein coding gene
  • IDs
    MGI:104698
    NCBI Gene: 233187
  • Gene Overview
    MyGene.info: LIM2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43430101-43435991 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.25 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104698
protein coding gene Chr7:43427670-43435996 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032121
protein coding gene Chr7:43441611-43449932 (+)
A/J MGP_AJ_G0032106
protein coding gene Chr7:42554599-42562922 (+)
AKR/J MGP_AKRJ_G0032036
protein coding gene Chr7:43924368-43932689 (+)
BALB/cJ MGP_BALBcJ_G0032111
protein coding gene Chr7:42669371-42677692 (+)
C3H/HeJ MGP_C3HHeJ_G0031827
protein coding gene Chr7:44423914-44432235 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032595
protein coding gene Chr7:45635336-45643657 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029618
protein coding gene Chr7:44676533-44684572 (+)
CAST/EiJ MGP_CASTEiJ_G0031157
protein coding gene Chr7:35598612-35607199 (+)
CBA/J MGP_CBAJ_G0031796
protein coding gene Chr7:47077280-47088117 (+)
DBA/2J MGP_DBA2J_G0031945
protein coding gene Chr7:42354376-42362679 (+)
FVB/NJ MGP_FVBNJ_G0031906
protein coding gene Chr7:42074165-42082486 (+)
LP/J MGP_LPJ_G0032024
protein coding gene Chr7:44180289-44188601 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031942
protein coding gene Chr7:46030525-46038846 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032615
protein coding gene Chr7:43053336-43061630 (+)
PWK/PhJ MGP_PWKPhJ_G0030878
protein coding gene Chr7:35793823-35802249 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030717
protein coding gene Chr7:31103567-31112066 (+)
WSB/EiJ MGP_WSBEiJ_G0031271
protein coding gene Chr7:43596138-43604462 (+)



Homology
more
  • Human Ortholog
    LIM2, lens intrinsic membrane protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LIM2, lens intrinsic membrane protein 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CTRCT19, MP17, MP19
  • Links
    NCBI Gene ID: 3982
    neXtProt AC: NX_P55344
    UniProt: P55344

  • Chr Location
    19q13.41; chr19:51379909-51387956 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Lim2 mouse models; 1 with human LIM2 associations

Human Disease Mouse Models
      
IDs
View 4 models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 4 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit microphthalmia, total lens opacity, disorganized lens fibers, posterior rupturing of lens capsule, and some have vacuolated lens. Heterozygotes exhibit the same dense cataract, but without microphthalmia or lens rupture.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 233187 NCBI Gene Model | MGI Sequence Detail 5891 C57BL/6J ±  kb
    transcript NM_177693 RefSeq | MGI Sequence Detail 886 C57BL/6  
    polypeptide P56563 UniProt | EBI | MGI Sequence Detail 173 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 2
      cDNA 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-27061, MGD-MRK-36104, MGI:107534
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Diseases 3
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:23988 Ehling UH, et al., Dominant cataract mutations and specific-locus mutations in mice induced by radiation or ethylnitrosourea. Mutat Res. 1982 Feb 22;92(1-2):181-92
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory