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Lim2
Gene Detail
Symbol

Name
ID
Lim2
lens intrinsic membrane protein 2
MGI:104698
Synonyms
19kDa, MP19
Feature Type
protein coding gene
Genetic Map
Chromosome 7
28.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr7:43430088-43435991 bp, + strand
From VEGA annotation of GRCm38

  5904 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12744  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LIM2
Protein SuperFamily: peripheral myelin protein 22/epithelial membrane protein
Gene Tree: Lim2

Human
homologs
LIM2, lens intrinsic membrane protein 2, 19kDa
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3982
neXtProt AC: NX_P55344

Human Synonyms: CTRCT19, MP17, MP19

Human Chr (Location): 19q13.4; chr19:51379909-51387956 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LIM2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(2) Gene trapped(3) Targeted(1) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants exhibit microphthalmia, total lens opacity, disorganized lens fibers, posterior rupturing of lens capsule, and some have vacuolated lens. Heterozygotes exhibit the same dense cataract, but without microphthalmia or lens rupture.
 
Human Diseases Modeled in Mice Using Lim2 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Lim2 interacts with 195 markers (Mir7b, Mir15a, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process camera-type eye development, lens development in camera-type eye
Component bicellular tight junction, plasma membrane, ...
Function structural constituent of eye lens
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (2)    Tissues (1)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lim2    NEW 
Molecular
reagents
All nucleic(10) Genomic(2) cDNA(8)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000039806 (Evidence)
Ensembl Gene Model ENSMUSG00000004613 (Evidence)
Entrez Gene 233187 (Evidence)
UniGene 267027
DFCI TC1585659
DoTS DT.483866, DT.94172483
NIA Mouse Gene Index U008012
Consensus CDS Project CCDS21168.1
International Mouse Phenotyping Consortium Status Lim2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039806 VEGA Gene Model | MGI Sequence Detail 5904 C57BL/6J ±  kb
transcript OTTMUST00000103473 VEGA | MGI Sequence Detail 879 Not Applicable 
polypeptide OTTMUSP00000057820 VEGA | MGI Sequence Detail 173 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2)
Polymorphisms
RFLP(4) : SNPs within 2kb(89 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000009813 lens fiber membrane intrinsic protein
References
(Earliest) J:23988 Ehling UH, et al., Dominant cataract mutations and specific-locus mutations in mice induced by radiation or ethylnitrosourea. Mutat Res. 1982 Feb 22;92(1-2):181-92
(Latest) J:181598 Shi Y, et al., Further analysis of the lens phenotype in Lim2-deficient mice. Invest Ophthalmol Vis Sci. 2011 Sep;52(10):7332-9
All references(40)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-27061, MGD-MRK-36104, MGI:107534

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory