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Lim2 Gene Detail
Summary
  • Symbol
    Lim2
  • Name
    lens intrinsic membrane protein 2
  • Synonyms
    19kDa, MP19
  • Feature Type
    protein coding gene
  • IDs
    MGI:104698
    NCBI Gene: 233187
  • Gene Overview
    MyGene.info: LIM2
Location & Maps
more
  • Sequence Map
    Chr7:43430088-43435996 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5909 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.25 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    LIM2, lens intrinsic membrane protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LIM2, lens intrinsic membrane protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CTRCT19, MP17, MP19
  • Links
    NCBI Gene ID: 3982
    neXtProt AC: NX_P55344

  • Chr Location
    19q13.4; chr19:51379909-51387956 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Lim2 mouse models; 1 with human LIM2 associations

Human Disease Mouse Models
       Cataract 19, Multiple Types; CTRCT19   OMIM: 615277 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 4 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (ENU)
    2
  • Gene trapped
    1
  • Targeted
    1
  • Transgenic
    1
  • Incidental Mutations
Homozygous mutants exhibit microphthalmia, total lens opacity, disorganized lens fibers, posterior rupturing of lens capsule, and some have vacuolated lens. Heterozygotes exhibit the same dense cataract, but without microphthalmia or lens rupture.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039806 VEGA Gene Model | MGI Sequence Detail 5909 C57BL/6J ±  kb
transcript OTTMUST00000103473 VEGA | MGI Sequence Detail 884 Not Applicable  
polypeptide OTTMUSP00000057820 VEGA | MGI Sequence Detail 173 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    91 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000009813 lens fiber membrane intrinsic protein
  • InterPro Domains
    IPR003935 Lens fibre membrane intrinsic protein
    IPR004032 PMP-22/EMP/MP20
    IPR004031 PMP-22/EMP/MP20/Claudin superfamily
Molecular
Reagents
less
  • All nucleic 10
    Genomic 2
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-27061, MGD-MRK-36104, MGI:107534
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Diseases 2
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:23988 Ehling UH, et al., Dominant cataract mutations and specific-locus mutations in mice induced by radiation or ethylnitrosourea. Mutat Res. 1982 Feb 22;92(1-2):181-92
  • Latest
    J:181598 Shi Y, et al., Further analysis of the lens phenotype in Lim2-deficient mice. Invest Ophthalmol Vis Sci. 2011 Sep;52(10):7332-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory