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Ncan
Gene Detail
Symbol

Name
ID
Ncan
neurocan
MGI:104694
Synonyms
Cspg3, Cspg3-rs, Tgfbit
Feature Type
protein coding gene
Genetic Map
Chromosome 8
34.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr8:70093085-70120873 bp, - strand
From VEGA annotation of GRCm38

  27789 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3229  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: NCAN
Gene Tree: Ncan

Human
homologs
NCAN, neurocan
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1463
neXtProt AC: NX_O14594

Human Synonyms: CSPG3

Human Chr (Location): 19p12; chr19:19211964-19252252 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for targeted null mutations are viable and fertile and exhibit normal behavior and brain anatomy; however, mild defects in long term potentiation were noted.
 
Interactions
Ncan interacts with 310 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cell adhesion, central nervous system development, ...
Component extracellular region, proteinaceous extracellular matrix
Function calcium ion binding, carbohydrate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (170)    Tissues (65)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 162
Northern blot 8
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ncan    NEW 
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(15) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000022194 (Evidence)
Ensembl Gene Model ENSMUSG00000002341 (Evidence)
Entrez Gene 13004 (Evidence)
DFCI TC1679619, TC1611851, TC1607954, TC1581272
DoTS DT.55193813, DT.101389061, DT.55269860
NIA Mouse Gene Index U029907
Consensus CDS Project CCDS22358.1
International Mouse Phenotyping Consortium Status Ncan
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022194 VEGA Gene Model | MGI Sequence Detail 27789 C57BL/6J ±  kb
transcript OTTMUST00000052725 VEGA | MGI Sequence Detail 7195 Not Applicable 
polypeptide OTTMUSP00000025040 VEGA | MGI Sequence Detail 1268 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR000538 Link
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000011019 neurocan core protein
References
(Earliest) J:17902 Weisz PV, et al., Expression of a TGF beta regulated, brain-specific mRNA in serum-free mouse embryo (SFME) cells. Neurosci Lett. 1993 May 14;154(1-2):153-6
(Latest) J:197152 Geissler M, et al., Primary hippocampal neurons, which lack four crucial extracellular matrix molecules, display abnormalities of synaptic structure and function and severe deficits in perineuronal net formation. J Neurosci. 2013 May 1;33(18):7742-55
All references(58)
Other
accession IDs
MGD-MRK-18658, MGD-MRK-27057, MGI:101837, MGI:1097681

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory