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Ncan Gene Detail
Summary
  • Symbol
    Ncan
  • Name
    neurocan
  • Synonyms
    Cspg3, Cspg3-rs, Tgfbit
  • Feature Type
    protein coding gene
  • IDs
    MGI:104694
    NCBI Gene: 13004
  • Gene Overview
    MyGene.info: NCAN
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:70093085-70120866 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104694
protein coding gene Chr8:70093085-70120873 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033689
protein coding gene Chr8:70341837-70369272 (-)
A/J MGP_AJ_G0033672
protein coding gene Chr8:67479443-67507475 (-)
AKR/J MGP_AKRJ_G0033597
protein coding gene Chr8:69399893-69427644 (-)
BALB/cJ MGP_BALBcJ_G0033668
protein coding gene Chr8:67709727-67737178 (-)
C3H/HeJ MGP_C3HHeJ_G0033378
protein coding gene Chr8:70045459-70072888 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034185
protein coding gene Chr8:72998375-73027711 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031129
protein coding gene Chr8:62299025-62327268 (-)
CAST/EiJ MGP_CASTEiJ_G0032703
protein coding gene Chr8:69527517-69558495 (-)
CBA/J MGP_CBAJ_G0033356
protein coding gene Chr8:75641710-75675438 (-)
DBA/2J MGP_DBA2J_G0033510
protein coding gene Chr8:67206400-67234193 (-)
FVB/NJ MGP_FVBNJ_G0033451
protein coding gene Chr8:66304831-66335573 (-)
LP/J MGP_LPJ_G0033597
protein coding gene Chr8:70381672-70409140 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033495
protein coding gene Chr8:78303843-78331556 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034203
protein coding gene Chr8:69580315-69608213 (-)
PWK/PhJ MGP_PWKPhJ_G0032411
protein coding gene Chr8:66491115-66519249 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032247
protein coding gene Chr8:68554154-68582997 (-)
WSB/EiJ MGP_WSBEiJ_G0032818
protein coding gene Chr8:69941362-69968851 (-)



Homology
more
  • Human Ortholog
    NCAN, neurocan
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NCAN, neurocan
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CSPG3
  • Links
    NCBI Gene ID: 1463
    neXtProt AC: NX_O14594
    UniProt: O14594

  • Chr Location
    19p13.11; chr19:19211973-19252252 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 3 alleles in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for targeted null mutations are viable and fertile and exhibit normal behavior and brain anatomy; however, mild defects in long term potentiation were noted.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13004 NCBI Gene Model | MGI Sequence Detail 27782 C57BL/6J ±  kb
transcript NM_007789 RefSeq | MGI Sequence Detail 7184 C57BL/6  
polypeptide P55066 UniProt | EBI | MGI Sequence Detail 1268 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 1
    cDNA 16
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-18658, MGD-MRK-27057, MGI:101837, MGI:1097681
References
more
  • Summaries
    All 63
    Developmental Gene Expression 15
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:17902 Weisz PV, et al., Expression of a TGF beta regulated, brain-specific mRNA in serum-free mouse embryo (SFME) cells. Neurosci Lett. 1993 May 14;154(1-2):153-6
  • Latest
    J:258970 Quattromani MJ, et al., Changes in resting-state functional connectivity after stroke in a mouse brain lacking extracellular matrix components. Neurobiol Dis. 2018 Apr;112:91-105

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory