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Ncan
Gene Detail
 Symbol
Name
ID
Ncan
neurocan
MGI:104694
Synonyms Cspg3, Cspg3-rs, Tgfbit
Feature Type protein coding gene
Genetic Map
Chromosome 8
34.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr8:70093085-70120873 bp, - strand
From VEGA annotation of GRCm38

  27789 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3229  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Ncan

Human
homologs
Human Homolog NCAN, neurocan
NCBI Gene ID 1463
neXtProt AC  NX_O14594
Human Synonyms  CSPG3
Human Chr (Location)  19p12; chr19:19211964-19252252 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for targeted null mutations are viable and fertile and exhibit normal behavior and brain anatomy; however, mild defects in long term potentiation were noted.
 
Interactions
Ncan interacts with 310 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell adhesion, regulation of synapse structural plasticity
Component extracellular region
Function calcium ion binding, carbohydrate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (170)    Tissues (65)    Images (28)
Theiler Stages: 19, 20, 22, 23, 24, 25, 27, 28
Assay TypeResults
RNA in situ 162
Northern blot 8
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(15) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000022194 (Evidence)
Ensembl Gene ModelENSMUSG00000002341 (Evidence)
Entrez Gene13004 (Evidence)
DFCITC1581272, TC1607954, TC1611851, TC1679619
DoTSDT.101389061, DT.55193813, DT.55269860
NIA Mouse Gene IndexU029907
Consensus CDS ProjectCCDS22358.1
International Mouse Knockout Project StatusNcan
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022194 VEGA Gene Model | MGI Sequence Detail 27789 C57BL/6J ±  kb
transcript OTTMUST00000052725 VEGA | MGI Sequence Detail 7195 Not Applicable 
polypeptide OTTMUSP00000025040 VEGA | MGI Sequence Detail 1268 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR000538 Link
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000011019 neurocan core protein
References (Earliest) J:17902 Weisz PV, et al., Expression of a TGF beta regulated, brain-specific mRNA in serum-free mouse embryo (SFME) cells. Neurosci Lett. 1993 May 14;154(1-2):153-6
(Latest) J:197152 Geissler M, et al., Primary hippocampal neurons, which lack four crucial extracellular matrix molecules, display abnormalities of synaptic structure and function and severe deficits in perineuronal net formation. J Neurosci. 2013 May 1;33(18):7742-55
All references(59)
Other
accession IDs
MGD-MRK-18658, MGD-MRK-27057, MGI:101837, MGI:1097681

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory