About   Help   FAQ
Crkl
Gene Detail
Symbol

Name
ID
Crkl
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
MGI:104686
Synonyms
1110025F07Rik, Crkol
Feature Type
protein coding gene
Genetic Map
Chromosome 16
10.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:17451987-17486255 bp, + strand
From VEGA annotation of GRCm38

  34269 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38021  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CRKL
Gene Tree: Crkl

Human
homologs
CRKL, v-crk avian sarcoma virus CT10 oncogene homolog-like
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1399
neXtProt AC: NX_P46109

Human Chr (Location): 22q11.21; chr22:20917398-20953749 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(8) Targeted(5) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit fetal lethality with abnormal heart, craniofacial, and brain morphology.
 
Human Diseases Modeled in Mice Using Crkl (2)    Mutations Annotated to Human Diseases (1)   
Interactions
Crkl interacts with 295 markers (Mir1b, Mir7-1, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process anterior/posterior pattern specification, blood vessel development, ...
Component cytoplasm, extracellular exosome
Function poly(A) RNA binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (126)    Tissues (89)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 51
Western blot 35
RT-PCR 40
cDNA source data(15)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase crkl ; ZFIN crkl    NEW 
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(15) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000025644 (Evidence)
Ensembl Gene Model ENSMUSG00000006134 (Evidence)
Entrez Gene 12929 (Evidence)
DFCI TC1599647, TC1595336, TC1575607, TC1652972, TC1646756
DoTS DT.110728191, DT.110728188, DT.101401077, DT.111105426, DT.99850764, DT.97371464
NIA Mouse Gene Index U376582, U101758, U016872
Consensus CDS Project CCDS28002.1
International Mouse Phenotyping Consortium Status Crkl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025644 VEGA Gene Model | MGI Sequence Detail 34269 C57BL/6J ±  kb
transcript OTTMUST00000063107 VEGA | MGI Sequence Detail 3863 Not Applicable 
polypeptide OTTMUSP00000031172 VEGA | MGI Sequence Detail 303 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000005883 Crk-like protein
References
(Earliest) J:29533 de Jong R, et al., Tyrosine phosphorylation of murine Crkl. Oncogene. 1995 Oct 19;11(8):1469-74
(Latest) J:220382 Huang Y, et al., CRK proteins selectively regulate T cell migration into inflamed tissues. J Clin Invest. 2015 Mar 2;125(3):1019-32
All references(54)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-27049, MGI:1915874, MGI:2146355, MGI:2146414

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory