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Crkl Gene Detail
Summary
  • Symbol
    Crkl
  • Name
    v-crk avian sarcoma virus CT10 oncogene homolog-like
  • Synonyms
    1110025F07Rik, Crkol
  • Feature Type
    protein coding gene
  • IDs
    MGI:104686
    NCBI Gene: 12929
  • Gene Overview
    MyGene.info: CRKL
Location & Maps
more
  • Sequence Map
    Chr16:17451987-17486255 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34269 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 10.82 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CRKL, CRK like proto-oncogene, adaptor protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRKL, CRK like proto-oncogene, adaptor protein
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 1399
    neXtProt AC: NX_P46109

  • Chr Location
    22q11.21; chr22:20917398-20953749 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 38021
    1 human;1 mouse;2 rat;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CRKL
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Crkl mouse models

Human Disease Mouse Models
       DiGeorge Syndrome; DGS   OMIM: 188400 View 1 model
Velocardiofacial Syndrome   OMIM: 192430 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 3 alleles in 4 genetic backgrounds
    19 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Gene trapped
    8
  • Targeted
    7
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for a null allele exhibit fetal lethality with abnormal heart, craniofacial, and brain morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025644 VEGA Gene Model | MGI Sequence Detail 34269 C57BL/6J ±  kb
transcript OTTMUST00000063107 VEGA | MGI Sequence Detail 3863 Not Applicable  
polypeptide OTTMUSP00000031172 VEGA | MGI Sequence Detail 303 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    90 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 2
    cDNA 15
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-27049, MGI:1915874, MGI:2146355, MGI:2146414
References
more
  • Summaries
    All 53
    Developmental Gene Expression 14
    Diseases 1
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:29533 de Jong R, et al., Tyrosine phosphorylation of murine Crkl. Oncogene. 1995 Oct 19;11(8):1469-74
  • Latest
    J:230261 Racedo SE, et al., Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation. Am J Hum Genet. 2015 Feb 5;96(2):235-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory