Crkl
Gene Detail

Symbol Name ID

Crkl v-crk sarcoma virus CT10 oncogene homolog (avian)-like MGI:104686

Synonyms

1110025F07Rik, Crkol

Feature Type

protein coding gene

Genetic Map

Chromosome 16

10.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:17451987-17486255 bp, + strand From VEGA annotation of GRCm38   34269 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38021  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Crkl

Human homologs

Human Homolog		CRKL, v-crk sarcoma virus CT10 oncogene homolog (avian)-like
NCBI Gene ID		1399
neXtProt AC		NX_P46109
Human Chr (Location)		22q11.21; chr22:21271714-21308037 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(13) : Targeted(5) Gene trapped(8)
 

Mice homozygous for a null allele exhibit fetal lethality with abnormal heart, craniofacial, and brain morphology.

 
Human Diseases Modeled Using Mouse Crkl (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	anterior/posterior pattern specification, blood vessel development, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (126)    Tissues (82)    Images (14)
Theiler Stages: 16, 17, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	51
Western blot	35
RT-PCR	40

cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(2) cDNA(15) Primer pair(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000025644 (Evidence)
Ensembl Gene Model	ENSMUSG00000006134 (Evidence)
Entrez Gene	12929 (Evidence)
DFCI	TC1575607, TC1595336, TC1599647, TC1646756, TC1652972
DoTS	DT.101401077, DT.110728188, DT.110728191, DT.111105426, DT.97371464, DT.99850764
NIA Mouse Gene Index	U016872, U101758, U376582
Consensus CDS Project	CCDS28002.1
International Mouse Knockout Project Status	Crkl

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025644	VEGA Gene Model | MGI Sequence Detail	34269	C57BL/6J
transcript	OTTMUST00000063107	VEGA | MGI Sequence Detail	3863	Not Applicable
polypeptide	OTTMUSP00000031172	VEGA | MGI Sequence Detail	303	Not Applicable

All sequences(54) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(85 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000980	SH2 domain
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR011511	Variant SH3
Protein Ontology	PR:000005883	Crk-like protein

References

(Earliest) J:29533 de Jong R, et al., Tyrosine phosphorylation of murine Crkl. Oncogene. 1995 Oct 19;11(8):1469-74
(Latest) J:188772 Voss AK, et al., MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome. Dev Cell. 2012 Sep 11;23(3):652-63
All references(52)

Other accession IDs

MGD-MRK-27049, MGI:1915874, MGI:2146355, MGI:2146414