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Crkl
Gene Detail
 Symbol
Name
ID
Crkl
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
MGI:104686
Synonyms 1110025F07Rik, Crkol
Feature Type protein coding gene
Genetic Map
Chromosome 16
10.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:17451987-17486255 bp, + strand
From VEGA annotation of GRCm38

  34269 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38021  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Crkl

Human
homologs
Human Homolog CRKL, v-crk avian sarcoma virus CT10 oncogene homolog-like
NCBI Gene ID 1399
neXtProt AC  NX_P46109
Human Chr (Location)  22q11.21; chr22:20917426-20953749 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(8) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit fetal lethality with abnormal heart, craniofacial, and brain morphology.
 
Human Diseases Modeled Using Mouse Crkl (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Crkl interacts with 295 markers (Mir1b, Mir7-1, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process anterior/posterior pattern specification, blood vessel development, ...
Component cytoplasm, extracellular vesicular exosome
Function poly(A) RNA binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (126)    Tissues (89)    Images (14)
Theiler Stages: 16, 17, 19, 20, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 51
Western blot 35
RT-PCR 40
cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(15) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000025644 (Evidence)
Ensembl Gene ModelENSMUSG00000006134 (Evidence)
Entrez Gene12929 (Evidence)
DFCITC1575607, TC1595336, TC1599647, TC1646756, TC1652972
DoTSDT.101401077, DT.110728188, DT.110728191, DT.111105426, DT.97371464, DT.99850764
NIA Mouse Gene IndexU016872, U101758, U376582
Consensus CDS ProjectCCDS28002.1
International Mouse Knockout Project StatusCrkl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025644 VEGA Gene Model | MGI Sequence Detail 34269 C57BL/6J ±  kb
transcript OTTMUST00000063107 VEGA | MGI Sequence Detail 3863 Not Applicable 
polypeptide OTTMUSP00000031172 VEGA | MGI Sequence Detail 303 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000005883 Crk-like protein
References (Earliest) J:29533 de Jong R, et al., Tyrosine phosphorylation of murine Crkl. Oncogene. 1995 Oct 19;11(8):1469-74
(Latest) J:188772 Voss AK, et al., MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome. Dev Cell. 2012 Sep 11;23(3):652-63
All references(54)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-27049, MGI:1915874, MGI:2146355, MGI:2146414

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory