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Man1a2 Gene Detail
Summary
  • Symbol
    Man1a2
  • Name
    mannosidase, alpha, class 1A, member 2
  • Synonyms
    Man1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:104676
    NCBI Gene: 17156
  • Gene Overview
    MyGene.info: MAN1A2
Location & Maps
more
  • Sequence Map
    Chr3:100562208-100685503 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      123296 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 43.71 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MAN1A2, mannosidase alpha class 1A member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAN1A2, mannosidase alpha class 1A member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MAN1B
  • Links
    NCBI Gene ID: 10905
    neXtProt AC: NX_O60476

  • Chr Location
    1p13; chr1:117367393-117528872 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Man1a2
  • Incidental Mutations
Homozygous mutation of this gene results in respiratory distress and death within a few hours after birth. Lung development is delayed, the alveolar septum is thickened, and hemorrhage occurs in the alveolar region.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007027 VEGA Gene Model | MGI Sequence Detail 123296 C57BL/6J ±  kb
transcript OTTMUST00000016265 VEGA | MGI Sequence Detail 7969 Not Applicable  
polypeptide OTTMUSP00000007449 VEGA | MGI Sequence Detail 641 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    437 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 198
    Genomic 4
    cDNA 190
    Primer pair 4

    Microarray probesets 10
Other
Accession IDs
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MGD-MRK-27039, MGI:2139702, MGI:2139752, MGI:2139837
References
more
  • Summaries
    All 44
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:17517 Herscovics A, et al., Isolation of a mouse Golgi mannosidase cDNA, a member of a gene family conserved from yeast to mammals. J Biol Chem. 1994 Apr 1;269(13):9864-71
  • Latest
    J:205561 Mott R, et al., The Architecture of Parent-of-Origin Effects in Mice. Cell. 2014 Jan 16;156(1-2):332-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory