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Ptpn12
Gene Detail
Symbol

Name
ID
Ptpn12
protein tyrosine phosphatase, non-receptor type 12
MGI:104673
Synonyms
P19-PTP, PTP-P19, PTP-PEST
Feature Type
protein coding gene
Genetic Map
Chromosome 5
9.83 cM, cytoband A3-B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:20986645-21055911 bp, - strand
From VEGA annotation of GRCm38

  69267 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37691  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: non-receptor tyrosine-protein phosphatase, type 12
Gene Tree: Ptpn12

Human
homologs
Human Homolog PTPN12, protein tyrosine phosphatase, non-receptor type 12
NCBI Gene ID 5782
neXtProt AC  NX_Q05209
Human Synonyms  PTPG1, PTP-PEST
Human Chr (Location)  7q11.23; chr7:77537456-77640071 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(10) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in early embryonic lethality, defective embryo turning, improper somitogenesis and vasculogenesis, impaired liver development, truncation of the caudal region and mesenchyme deficiency.
 
Interactions
Ptpn12 interacts with 294 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process dephosphorylation, peptidyl-tyrosine dephosphorylation, ...
Component cell junction, cell projection, ...
Function hydrolase activity, phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (51)    Tissues (27)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 16
Northern blot 5
Western blot 9
RT-PCR 17
cDNA source data(81)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(94) Genomic(8) cDNA(83) Primer pair(2) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000029737 (Evidence)
Ensembl Gene ModelENSMUSG00000028771 (Evidence)
Entrez Gene19248 (Evidence)
UniGene319117
DFCITC1578420, TC1614995
DoTSDT.101378478, DT.103565680, DT.110646033, DT.87050238, DT.94152912
NIA Mouse Gene IndexU025960, U041017
EC3.1.3.48
Consensus CDS ProjectCCDS19102.1
International Mouse Knockout Project StatusPtpn12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029737 VEGA Gene Model | MGI Sequence Detail 69267 C57BL/6J ±  kb
transcript OTTMUST00000073786 VEGA | MGI Sequence Detail 3280 Not Applicable 
polypeptide OTTMUSP00000038239 VEGA | MGI Sequence Detail 775 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(10) UniProt(4)
Polymorphisms
SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR012266 Protein-tyrosine phosphatase, non-receptor type-12
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013450 tyrosine-protein phosphatase non-receptor type 12
References
(Earliest) J:29004 Yi T, et al., Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Blood. 1991 Nov 1;78(9):2222-8
(Latest) J:204493 Rhee I, et al., Macrophage fusion is controlled by the cytoplasmic protein tyrosine phosphatase PTP-PEST/PTPN12. Mol Cell Biol. 2013 Jun;33(12):2458-69
All references(56)
Other
accession IDs
MGD-MRK-27036

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory