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Ptpn12 Gene Detail
Summary
  • Symbol
    Ptpn12
  • Name
    protein tyrosine phosphatase, non-receptor type 12
  • Synonyms
    P19-PTP, PTP-P19, PTP-PEST
  • Feature Type
    protein coding gene
  • IDs
    MGI:104673
    NCBI Gene: 19248
Location & Maps
more
  • Sequence Map
    Chr5:20986645-21055911 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      69267 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PTPN12, protein tyrosine phosphatase, non-receptor type 12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTPN12, protein tyrosine phosphatase, non-receptor type 12
    Orthology source: HomoloGene
  • Synonyms
    PTPG1, PTP-PEST
  • Links
    NCBI Gene ID: 5782
    neXtProt AC: NX_Q05209

  • Chr Location
    7q11.23; chr7:77537456-77640071 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    2
  • Gene trapped
    10
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    6
  • Genomic Mutations
    4 involving Ptpn12
  • Incidental Mutations
Homozygous mutation of this gene results in early embryonic lethality, defective embryo turning, improper somitogenesis and vasculogenesis, impaired liver development, truncation of the caudal region and mesenchyme deficiency.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029737 VEGA Gene Model | MGI Sequence Detail 69267 C57BL/6J ±  kb
transcript OTTMUST00000073786 VEGA | MGI Sequence Detail 3280 Not Applicable  
polypeptide OTTMUSP00000038239 VEGA | MGI Sequence Detail 775 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    110 from dbSNP Build 137
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013450 tyrosine-protein phosphatase non-receptor type 12
  • EC
  • InterPro Domains
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR029021 Protein-tyrosine phosphatase-like
    IPR012266 Protein-tyrosine phosphatase, non-receptor type-12
    IPR000242 PTP type protein phosphatase
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
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  • All nucleic 94
    Genomic 8
    cDNA 83
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-27036
References
more
  • Summaries
    All 52
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 11
    Phenotypes 21
  • Earliest
    J:29004 Yi T, et al., Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Blood. 1991 Nov 1;78(9):2222-8
  • Latest
    J:224425 Lee HS, et al., Protein tyrosine phosphatase-PEST and beta8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells. Mol Cell Biol. 2015 Apr;35(8):1401-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory