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Ptpn12 Gene Detail
Summary
  • Symbol
    Ptpn12
  • Name
    protein tyrosine phosphatase, non-receptor type 12
  • Synonyms
    P19-PTP, PTP-P19, PTP-PEST
  • Feature Type
    protein coding gene
  • IDs
    MGI:104673
    NCBI Gene: 19248
  • Gene Overview
    MyGene.info: PTPN12
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:20986645-21055911 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 9.83 cM, cytoband A3-B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104673
protein coding gene Chr5:20986645-21055988 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029313
protein coding gene Chr5:18517593-18594886 (-)
A/J MGP_AJ_G0029278
protein coding gene Chr5:17928585-17998784 (-)
AKR/J MGP_AKRJ_G0029229
protein coding gene Chr5:18604487-18678334 (-)
BALB/cJ MGP_BALBcJ_G0029290
protein coding gene Chr5:18355997-18428351 (-)
C3H/HeJ MGP_C3HHeJ_G0029009
protein coding gene Chr5:18671970-18743125 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029743
protein coding gene Chr5:19884257-19966462 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026982
protein coding gene Chr5:16004787-16077145 (-)
CAST/EiJ MGP_CASTEiJ_G0028421
protein coding gene Chr5:18000801-18078431 (-)
CBA/J MGP_CBAJ_G0028976
protein coding gene Chr5:20111339-20191992 (-)
DBA/2J MGP_DBA2J_G0029128
protein coding gene Chr5:18207629-18280778 (-)
FVB/NJ MGP_FVBNJ_G0029086
protein coding gene Chr5:17619488-17689769 (-)
LP/J MGP_LPJ_G0029212
protein coding gene Chr5:18930133-19005675 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029114
protein coding gene Chr5:21424997-21502574 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029776
protein coding gene Chr5:18274808-18347625 (-)
PWK/PhJ MGP_PWKPhJ_G0028144
protein coding gene Chr5:17270958-17339387 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027977
protein coding gene Chr5:17632724-17705568 (-)
WSB/EiJ MGP_WSBEiJ_G0028501
protein coding gene Chr5:18325113-18395500 (-)



Homology
more
  • Human Ortholog
    PTPN12, protein tyrosine phosphatase, non-receptor type 12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTPN12, protein tyrosine phosphatase, non-receptor type 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PTPG1, PTP-PEST
  • Links
    NCBI Gene ID: 5782
    neXtProt AC: NX_Q05209
    UniProt: Q05209

  • Chr Location
    7q11.23; chr7:77537160-77640071 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 3 alleles in 4 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in early embryonic lethality, defective embryo turning, improper somitogenesis and vasculogenesis, impaired liver development, truncation of the caudal region and mesenchyme deficiency.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028771 Ensembl Gene Model | MGI Sequence Detail 69267 C57BL/6J ±  kb
    transcript ENSMUST00000030556 Ensembl | MGI Sequence Detail 3280 Not Applicable  
    polypeptide ENSMUSP00000030556 Ensembl | MGI Sequence Detail 775 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      Genomic 8
      cDNA 84
      Primer pair 3
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-27036
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 11
      Phenotypes 24
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory