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Man2a1
Gene Detail
 Symbol
Name
ID
Man2a1
mannosidase 2, alpha 1
MGI:104669
Synonyms Mana2, Mana-2, Map-2
Feature Type protein coding gene
Genetic Map
Chromosome 17
33.76 cM, cytoband E1.2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:64600736-64755110 bp, + strand
From VEGA annotation of GRCm38

  154375 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1777  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: lysosomal alpha-mannosidase
Gene Tree: Man2a1

Human
homologs
Human Homolog MAN2A1, mannosidase, alpha, class 2A, member 1
NCBI Gene ID 4124
neXtProt AC  NX_Q16706
Human Synonyms  AMan II, GOLIM7, MANA2, MANII
Human Chr (Location)  5q21.3; chr5:109689366-109869625 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(5) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in premature death, dyserythropoiesis, systemic autoimmune disease, including an increase in serum immunoglobulins, glomerulonephritis, and hematuria,
 
Human Diseases Modeled Using Mouse Man2a1 (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Man2a1 interacts with 336 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process carbohydrate metabolic process, in utero embryonic development, ...
Component cis-Golgi network, extracellular vesicular exosome, ...
Function alpha-mannosidase activity, carbohydrate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (96)    Tissues (95)    Images (1)
Theiler Stages: 22, 28
Assay TypeResults
RNA in situ 94
Northern blot 2
cDNA source data(94)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(94) cDNA(94)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036800 (Evidence)
Ensembl Gene ModelENSMUSG00000024085 (Evidence)
Entrez Gene17158 (Evidence)
UniGene2433
DFCITC1575328
DoTSDT.494061
NIA Mouse Gene IndexU018170
EC3.2.1.114
Consensus CDS ProjectCCDS28938.1
International Mouse Knockout Project StatusMan2a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036800 VEGA Gene Model | MGI Sequence Detail 154375 C57BL/6J ±  kb
transcript OTTMUST00000094446 VEGA | MGI Sequence Detail 6991 Not Applicable 
polypeptide OTTMUSP00000052525 VEGA | MGI Sequence Detail 1150 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(800 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011013 Galactose mutarotase-like domain
InterPro IPR027291 Glycoside hydrolase 38/57, N-terminal domain
InterPro IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
InterPro IPR015341 Glycoside hydrolase, family 38, central domain
InterPro IPR000602 Glycoside hydrolase family 38, N-terminal domain
InterPro IPR013780 Glycosyl hydrolase, family 13, all-beta
InterPro IPR011682 Glycosyl hydrolase family 38, C-terminal
Protein Ontology PR:000010105 alpha-mannosidase 2
References (Earliest) J:5798 Dizik M, et al., A gene apparently determining the extent of sialylation of lysosomal alpha-mannosidase in mouse liver. Biochem Genet. 1977 Feb;15(1-2):31-46
(Latest) J:193786 Elkis Y, et al., Testosterone deficiency accompanied by testicular and epididymal abnormalities in TMF(-/-) mice. Mol Cell Endocrinol. 2013 Jan 5;365(1):52-63
All references(54)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-12109, MGD-MRK-12110, MGD-MRK-27032

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory