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Man2a1
Gene Detail
Symbol

Name
ID
Man2a1
mannosidase 2, alpha 1
MGI:104669
Synonyms
Mana2, Mana-2, Map-2
Feature Type
protein coding gene
Genetic Map
Chromosome 17
33.76 cM, cytoband E1.2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:64600736-64755110 bp, + strand
From VEGA annotation of GRCm38

  154375 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1777  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: MAN2A1
Protein SuperFamily: lysosomal alpha-mannosidase
Gene Tree: Man2a1

Human
homologs
MAN2A1, mannosidase, alpha, class 2A, member 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4124
neXtProt AC: NX_Q16706

Human Synonyms: AMan II, GOLIM7, MANA2, MANII

Human Chr (Location): 5q21.3; chr5:109689366-109869625 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(5) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in premature death, dyserythropoiesis, systemic autoimmune disease, including an increase in serum immunoglobulins, glomerulonephritis, and hematuria,
 
Human Diseases Modeled in Mice Using Man2a1 (2)    Mutations Annotated to Human Diseases (1)   
Interactions
Man2a1 interacts with 336 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process carbohydrate metabolic process, in utero embryonic development, ...
Component cis-Golgi network, extracellular exosome, ...
Function alpha-mannosidase activity, carbohydrate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (96)    Tissues (95)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 2
cDNA source data(94)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase man2a1    NEW 
Molecular
reagents
All nucleic(94) cDNA(94)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000036800 (Evidence)
Ensembl Gene Model ENSMUSG00000024085 (Evidence)
Entrez Gene 17158 (Evidence)
UniGene 2433
DFCI TC1575328
DoTS DT.494061
NIA Mouse Gene Index U018170
EC 3.2.1.114
Consensus CDS Project CCDS28938.1
International Mouse Phenotyping Consortium Status Man2a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036800 VEGA Gene Model | MGI Sequence Detail 154375 C57BL/6J ±  kb
transcript OTTMUST00000094446 VEGA | MGI Sequence Detail 6991 Not Applicable 
polypeptide OTTMUSP00000052525 VEGA | MGI Sequence Detail 1150 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(800 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011013 Galactose mutarotase-like domain
InterPro IPR027291 Glycoside hydrolase 38/57, N-terminal domain
InterPro IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
InterPro IPR015341 Glycoside hydrolase, family 38, central domain
InterPro IPR000602 Glycoside hydrolase family 38, N-terminal domain
InterPro IPR013780 Glycosyl hydrolase, family 13, all-beta
InterPro IPR011682 Glycosyl hydrolase family 38, C-terminal
Protein Ontology PR:000010105 alpha-mannosidase 2
References
(Earliest) J:5798 Dizik M, et al., A gene apparently determining the extent of sialylation of lysosomal alpha-mannosidase in mouse liver. Biochem Genet. 1977 Feb;15(1-2):31-46
(Latest) J:193786 Elkis Y, et al., Testosterone deficiency accompanied by testicular and epididymal abnormalities in TMF(-/-) mice. Mol Cell Endocrinol. 2013 Jan 5;365(1):52-63
All references(52)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-12109, MGD-MRK-12110, MGD-MRK-27032

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory