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Man2a1 Gene Detail
Summary
  • Symbol
    Man2a1
  • Name
    mannosidase 2, alpha 1
  • Synonyms
    Mana2, Mana-2, Map-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104669
    NCBI Gene: 17158
  • Gene Overview
    MyGene.info: MAN2A1
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:64601649-64755110 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 33.76 cM, cytoband E1.2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    799 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104669
protein coding gene Chr17:64600736-64755110 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023974
protein coding gene Chr17:66689491-66850698 (+)
A/J MGP_AJ_G0023932
protein coding gene Chr17:64719699-64874727 (+)
AKR/J MGP_AKRJ_G0023901
protein coding gene Chr17:65602431-65759303 (+)
BALB/cJ MGP_BALBcJ_G0023933
protein coding gene Chr17:64643819-64799858 (+)
C3H/HeJ MGP_C3HHeJ_G0023697
protein coding gene Chr17:66479892-66636938 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024379
protein coding gene Chr17:69309492-69476290 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021825
protein coding gene Chr17:60809394-60966977 (+)
CAST/EiJ MGP_CASTEiJ_G0023179
protein coding gene Chr17:66824721-66987000 (+)
CBA/J MGP_CBAJ_G0023673
protein coding gene Chr17:72061510-72229779 (+)
DBA/2J MGP_DBA2J_G0023801
protein coding gene Chr17:63471180-63627852 (+)
FVB/NJ MGP_FVBNJ_G0023767
protein coding gene Chr17:62951176-63105445 (+)
LP/J MGP_LPJ_G0023883
protein coding gene Chr17:67435549-67595985 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023795
protein coding gene Chr17:72133547-72295580 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024423
protein coding gene Chr17:66060091-66221697 (+)
PWK/PhJ MGP_PWKPhJ_G0022925
protein coding gene Chr17:62734960-62890026 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022736
protein coding gene Chr17:62746146-62938237 (+)
WSB/EiJ MGP_WSBEiJ_G0023245
protein coding gene Chr17:66756349-66926111 (+)



Homology
more
  • Human Ortholog
    MAN2A1, mannosidase alpha class 2A member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MAN2A1, mannosidase alpha class 2A member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AMan II, GOLIM7, MANA2, MANII
  • Links
    NCBI Gene ID: 4124
    neXtProt AC: NX_Q16706
    UniProt: Q16706

  • Chr Location
    5q21.3; chr5:109689366-109869625 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Man2a1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 1 allele in 1 genetic background
    14 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in premature death, dyserythropoiesis, systemic autoimmune disease, including an increase in serum immunoglobulins, glomerulonephritis, and hematuria,
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17158 NCBI Gene Model | MGI Sequence Detail 153462 C57BL/6J ±  kb
    transcript NM_008549 RefSeq | MGI Sequence Detail 6091 C57BL/6  
    polypeptide P27046 UniProt | EBI | MGI Sequence Detail 1150 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000010105 alpha-mannosidase 2
    • EC
    • InterPro Domains
      IPR011013 Galactose mutarotase-like domain superfamily
      IPR027291 Glycoside hydrolase 38, N-terminal domain superfamily
      IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
      IPR028995 Glycoside hydrolase families 57/38, central domain superfamily
      IPR015341 Glycoside hydrolase family 38, central domain
      IPR037094 Glycoside hydrolase family 38, central domain superfamily
      IPR000602 Glycoside hydrolase family 38, N-terminal domain
      IPR013780 Glycosyl hydrolase, all-beta
      IPR011682 Glycosyl hydrolase family 38, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 95
      cDNA 95

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12109, MGD-MRK-12110, MGD-MRK-27032
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 13
      Phenotypes 10
    • Earliest
      J:5798 Dizik M, et al., A gene apparently determining the extent of sialylation of lysosomal alpha-mannosidase in mouse liver. Biochem Genet. 1977 Feb;15(1-2):31-46
    • Latest
      J:193786 Elkis Y, et al., Testosterone deficiency accompanied by testicular and epididymal abnormalities in TMF(-/-) mice. Mol Cell Endocrinol. 2013 Jan 5;365(1):52-63

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory