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Hmmr
Gene Detail
 Symbol
Name
ID
Hmmr
hyaluronan mediated motility receptor (RHAMM)
MGI:104667
Synonyms CD168, Rhamm
Feature Type protein coding gene
Genetic Map
Chromosome 11
24.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:40701395-40733422 bp, - strand
From VEGA annotation of GRCm38

  32028 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8271  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Hmmr

Human
homologs
Human Homolog HMMR, hyaluronan-mediated motility receptor (RHAMM)
NCBI Gene ID 3161
neXtProt AC  NX_O75330
Human Synonyms  CD168, IHABP, RHAMM
Human Chr (Location)  5q34; chr5:163460511-163491945 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HMMR
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(19) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for mutations of this gene are viable and show no gross anatomical abnormalities, however fertility is impaired. It has also been shown that mutant mice are less susceptible to the formation of aggressive fibromatosis.
 
Interactions
Hmmr interacts with 214 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Component cytoplasm, membrane
Function hyaluronic acid binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (1)    Images (1)
Theiler Stages: 22
Assay TypeResults
RT-PCR 2
cDNA source data(122)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(131) Genomic(5) cDNA(124) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000005436 (Evidence)
Ensembl Gene ModelENSMUSG00000020330 (Evidence)
Entrez Gene15366 (Evidence)
UniGene116997
DFCITC1578268, TC1591925, TC1618835, TC1652733
DoTSDT.101404079, DT.101737170, DT.103579521, DT.103579525, DT.40163982, DT.87049253, DT.97397410
NIA Mouse Gene IndexU032666
Consensus CDS ProjectCCDS24548.1
International Mouse Knockout Project StatusHmmr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005436 VEGA Gene Model | MGI Sequence Detail 32028 C57BL/6J ±  kb
transcript OTTMUST00000012114 VEGA | MGI Sequence Detail 3892 Not Applicable 
polypeptide OTTMUSP00000005604 VEGA | MGI Sequence Detail 794 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(10) UniProt(5)
Polymorphisms PCR(1) : SNPs within 2kb(183 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026203 Intracellular hyaluronic acid binding protein
Protein Ontology PR:000001856 hyaluronan mediated motility receptor
References (Earliest) J:29333 Hardwick C, et al., Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility [published erratum appears in J Cell Biol 1992 Aug;118(3):753]. J Cell Biol. 1992 Jun;117(6):1343-50
(Latest) J:188584 Tolg C, et al., A RHAMM Mimetic Peptide Blocks Hyaluronan Signaling and Reduces Inflammation and Fibrogenesis in Excisional Skin Wounds. Am J Pathol. 2012 Oct;181(4):1250-70
All references(44)
Other
accession IDs
MGD-MRK-26076, MGD-MRK-27030, MGI:3034596

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory