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Hmmr Gene Detail
Summary
  • Symbol
    Hmmr
  • Name
    hyaluronan mediated motility receptor (RHAMM)
  • Synonyms
    CD168, Rhamm
  • Feature Type
    protein coding gene
  • IDs
    MGI:104667
    NCBI Gene: 15366
Location & Maps
more
  • Sequence Map
    Chr11:40701395-40733422 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      32028 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 24.40 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HMMR, hyaluronan mediated motility receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HMMR, hyaluronan mediated motility receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD168, IHABP, RHAMM
  • Links
    NCBI Gene ID: 3161
    neXtProt AC: NX_O75330

  • Chr Location
    5q34; chr5:163460511-163491945 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8271
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: HMMR
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human HMMR associations

Human Disease Mouse Models
       Breast Cancer   OMIM: 114480
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Chemically induced (other)
    1
  • Gene trapped
    19
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Hmmr
  • Incidental Mutations
Mice homozygous for mutations of this gene exhibit impaired fertility and are less susceptible to the formation of aggressive fibromatosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005436 VEGA Gene Model | MGI Sequence Detail 32028 C57BL/6J ±  kb
transcript OTTMUST00000012114 VEGA | MGI Sequence Detail 3892 Not Applicable  
polypeptide OTTMUSP00000005604 VEGA | MGI Sequence Detail 794 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    181 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000001856 hyaluronan mediated motility receptor
  • InterPro Domains
    IPR031794 Hyaluronan-mediated motility receptor, C-terminal
    IPR031787 Hyaluronan mediated motility receptor, N-terminal
    IPR026203 Intracellular hyaluronic acid binding protein
Molecular
Reagents
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  • All nucleic 131
    Genomic 5
    cDNA 124
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-26076, MGD-MRK-27030, MGI:3034596
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:29333 Hardwick C, et al., Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility [published erratum appears in J Cell Biol 1992 Aug;118(3):753]. J Cell Biol. 1992 Jun;117(6):1343-50
  • Latest
    J:221355 Li H, et al., RHAMM deficiency disrupts folliculogenesis resulting in female hypofertility. Biol Open. 2015;4(4):562-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory