Hmmr
Gene Detail

Symbol Name ID

Hmmr hyaluronan mediated motility receptor (RHAMM) MGI:104667

Synonyms

CD168, Rhamm

Feature Type

protein coding gene

Genetic Map

Chromosome 11

24.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:40701395-40733422 bp, - strand From VEGA annotation of GRCm38   32028 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8271  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hmmr

Human homologs

Human Homolog		HMMR, hyaluronan-mediated motility receptor (RHAMM)
NCBI Gene ID		3161
neXtProt AC		NX_O75330
Human Synonyms		CD168, IHABP, RHAMM
Human Chr (Location)		5q33.2-qter; chr5:162887517-162918951 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HMMR

Alleles and phenotypes

All alleles(23) : Targeted(4) Gene trapped(19)
 

Mice homozygous for mutations of this gene are viable and show no gross anatomical abnormalities, however fertility is impaired. It has also been shown that mutant mice are less susceptible to the formation of aggressive fibromatosis.

 

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Component	cytoplasm
Function	hyaluronic acid binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
cDNA source data(122)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(130) Genomic(5) cDNA(124) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000005436 (Evidence)
Ensembl Gene Model	ENSMUSG00000020330 (Evidence)
Entrez Gene	15366 (Evidence)
UniGene	116997
DFCI	TC1578268, TC1591925, TC1618835, TC1652733
DoTS	DT.101404079, DT.101737170, DT.103579521, DT.103579525, DT.40163982, DT.87049253, DT.97397410
NIA Mouse Gene Index	U032666
Consensus CDS Project	CCDS24548.1
International Mouse Knockout Project Status	Hmmr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005436	VEGA Gene Model | MGI Sequence Detail	32028	C57BL/6J
transcript	OTTMUST00000012114	VEGA | MGI Sequence Detail	3531	Not Applicable
polypeptide	OTTMUSP00000005604	VEGA | MGI Sequence Detail	794	Not Applicable

All sequences(53) RefSeq(2) UniProt(5)

Polymorphisms

PCR(1) : SNPs(135 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026203	Intracellular hyaluronic acid binding protein
Protein Ontology	PR:000001856	hyaluronan mediated motility receptor

References

(Earliest) J:29333 Hardwick C, et al., Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility [published erratum appears in J Cell Biol 1992 Aug;118(3):753]. J Cell Biol. 1992 Jun;117(6):1343-50
(Latest) J:188584 Tolg C, et al., A RHAMM Mimetic Peptide Blocks Hyaluronan Signaling and Reduces Inflammation and Fibrogenesis in Excisional Skin Wounds. Am J Pathol. 2012 Oct;181(4):1250-70
All references(43)

Other accession IDs

MGD-MRK-26076, MGD-MRK-27030, MGI:3034596