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Soat1
Gene Detail
Symbol

Name
ID
Soat1
sterol O-acyltransferase 1
MGI:104665
Synonyms
8430426K15Rik, Acact, ACAT-1, hid
Feature Type
protein coding gene
Genetic Map
Chromosome 1
67.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr1:156424525-156474331 bp, - strand
From VEGA annotation of GRCm38

  49807 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2333  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: sterol O-acyltransferase, ACAT/DAG/ARE types
Gene Tree: Soat1

Human
homologs
Human Homolog SOAT1, sterol O-acyltransferase 1
NCBI Gene ID 6646
neXtProt AC  NX_P35610
Human Synonyms  ACACT, ACAT, ACAT1, ACAT-1, SOAT, STAT
Human Chr (Location)  1q25; chr1:179293714-179358680 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Chemically induced (ENU)(1) Gene trapped(10) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mutants producing no protein or a truncated protein show depletion of cholesterol esters in adrenal cortex and peritoneal macrophages. Additionally, null mutants have reduced eye openings due to atrophy of meibomian glands or abnromal morphology and arrangement of medullary cells of all hair types.
 
Phenotype Images(7)
Interactions
Soat1 interacts with 307 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cholesterol efflux, cholesterol esterification, ...
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function cholesterol binding, cholesterol O-acyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (147)    Tissues (100)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 147
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(25) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000049652 (Evidence)
Ensembl Gene ModelENSMUSG00000026600 (Evidence)
Entrez Gene20652 (Evidence)
NIA Mouse Gene IndexU021929
EC2.3.1.26
Consensus CDS ProjectCCDS35743.1
International Mouse Knockout Project StatusSoat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049652 VEGA Gene Model | MGI Sequence Detail 49807 C57BL/6J ±  kb
transcript OTTMUST00000126489 VEGA | MGI Sequence Detail 8371 Not Applicable 
polypeptide OTTMUSP00000068389 VEGA | MGI Sequence Detail 540 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(4) UniProt(7)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(692 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004299 Membrane bound O-acyl transferase, MBOAT
InterPro IPR014371 Sterol O-acyltransferase, ACAT/DAG/ARE types
Protein Ontology PR:000015389 sterol O-acyltransferase 1
References
(Earliest) J:166508 ARNESEN K, Constitutional difference in lipid content of adrenals in two strains of mice and their hybrids. Acta Endocrinol (Copenh). 1955 Apr;18(4):396-401
(Latest) J:195664 Rice RH, et al., Differentiating inbred mouse strains from each other and those with single gene mutations using hair proteomics. PLoS One. 2012;7(12):e51956
All references(84)
Other
accession IDs
MGD-MRK-10717, MGD-MRK-1274, MGD-MRK-26105, MGI:1921100, MGI:2138610, MGI:87992, MGI:96088

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory