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Tcf15
Gene Detail
 Symbol
Name
ID
Tcf15
transcription factor 15
MGI:104664
Synonyms bHLH-EC2, Meso1, paraxis
Feature Type protein coding gene
Genetic Map
Chromosome 2
74.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:152143561-152149097 bp, + strand
From VEGA annotation of GRCm38

  5537 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37943  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: basic helix-loop-helix transcription factor, Twist/Epicardin/Musculin types
Gene Tree: Tcf15

Human
homologs
Human Homolog TCF15, transcription factor 15 (basic helix-loop-helix)
NCBI Gene ID 6939
neXtProt AC  NX_Q12870
Human Synonyms  bHLHa40, EC2, PARAXIS
Human Chr (Location)  20p13; chr20:603993-610266 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(6) Targeted(1)
 
In homozygotes for a targeted null mutation, cells of the paraxial mesoderm fail to form epithelia resulting in disrupted somites, patterning defects of the axial skeleton, peripheral nerves, and skeletal muscles, and perinatal lethality.
 
Interactions
Tcf15 interacts with 53 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process anterior/posterior pattern specification, death, ...
Component nucleus
Function DNA binding, protein dimerization activity
External Resources: FuncBase
Expression
Literature Summary: (48 records)
Data Summary: Results (134)    Tissues (43)    Images (65)
Theiler Stages: 2, 3, 11, 12, 13, 14, 15, 16, 17, 19, 28
Assay TypeResults
RNA in situ 90
Northern blot 8
RT-PCR 36
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(18) Primer pair(2) Other(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015848 (Evidence)
Ensembl Gene ModelENSMUSG00000068079 (Evidence)
Entrez Gene21407 (Evidence)
UniGene3881
DFCITC1588161
DoTSDT.523551
NIA Mouse Gene IndexU002636
Consensus CDS ProjectCCDS16878.1
International Mouse Knockout Project StatusTcf15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015848 VEGA Gene Model | MGI Sequence Detail 5537 C57BL/6J ±  kb
transcript OTTMUST00000037667 VEGA | MGI Sequence Detail 980 Not Applicable 
polypeptide OTTMUSP00000016890 VEGA | MGI Sequence Detail 195 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(33 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000016177 transcription factor 15
References (Earliest) J:24364 Burgess R, et al., Paraxis: a basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites. Dev Biol. 1995 Apr;168(2):296-306
(Latest) J:202837 Rowton M, et al., Regulation of mesenchymal-to-epithelial transition by PARAXIS during somitogenesis. Dev Dyn. 2013 Nov;242(11):1332-44
All references(80)
Other
accession IDs
MGD-MRK-26104

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory