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Dll1
Gene Detail
Symbol

Name
ID
Dll1
delta-like 1 (Drosophila)
MGI:104659
Synonyms
Delta1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
8.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:15367354-15376872 bp, - strand
From VEGA annotation of GRCm38

  9519 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4104  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: delta-like protein
Gene Tree: Dll1

Human
homologs
Human Homolog DLL1, delta-like 1 (Drosophila)
NCBI Gene ID 28514
neXtProt AC  NX_O00548
Human Synonyms  Delta, DELTA1, DL1
Human Chr (Location)  6q27; chr6:170282200-170290727 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null embryos do not survive and have mesodermal segments with no cranio-caudal polarity and no epithelial somites develop; caudal sclerotome halves do not condense, the pattern. Mice heterozygous for a knock-out or ENU allele exhibit abnormal metabolic and immunological phenotypes.
 
Interactions
Dll1 interacts with 244 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process auditory receptor cell differentiation, auditory receptor cell fate commitment, ...
Component cytoplasmic vesicle, integral component of membrane, ...
Function calcium ion binding, Notch binding, ...
External Resources: FuncBase
Expression
Literature Summary: (280 records)
Data Summary: Results (1071)    Tissues (488)    Images (252)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 955
In situ reporter (knock in) 72
Northern blot 5
RT-PCR 34
cDNA source data(43)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(84) Genomic(2) cDNA(49) Primer pair(11) Other(22)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021037 (Evidence)
Ensembl Gene ModelENSMUSG00000014773 (Evidence)
Entrez Gene13388 (Evidence)
UniGene4875
DFCITC1603157, TC1582472, TC1609846
DoTSDT.527335, DT.94248616
NIA Mouse Gene IndexU037448
Consensus CDS ProjectCCDS37452.1
International Mouse Knockout Project StatusDll1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021037 VEGA Gene Model | MGI Sequence Detail 9519 C57BL/6J ±  kb
transcript OTTMUST00000049746 VEGA | MGI Sequence Detail 3581 Not Applicable 
polypeptide OTTMUSP00000023104 VEGA | MGI Sequence Detail 722 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001774 Delta/Serrate/lag-2 (DSL) protein
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR011651 Notch ligand, N-terminal
Protein Ontology PR:000006523 delta-like protein 1
References
(Earliest) J:28006 Bettenhausen B, et al., Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. Development. 1995 Aug;121(8):2407-18
(Latest) J:214082 Maurer KA, et al., Notch signaling differentially regulates Atoh7 and Neurog2 in the distal mouse retina. Development. 2014 Aug;141(16):3243-54
All references(367)
Other
accession IDs
MGD-MRK-26099

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory