Dll1
Gene Detail

Symbol Name ID

Dll1 delta-like 1 (Drosophila) MGI:104659

Synonyms

Delta1

Feature Type

protein coding gene

Genetic Map

Chromosome 17

8.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr17:15367354-15376872 bp, - strand From VEGA annotation of GRCm38   9519 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4104  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: delta-like protein
Gene Tree: Dll1

Human homologs

Human Homolog		DLL1, delta-like 1 (Drosophila)
NCBI Gene ID		28514
neXtProt AC		NX_O00548
Human Synonyms		Delta, DELTA1, DL1
Human Chr (Location)		6q27; chr6:170591294-170599697 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(8) Chemically induced(2)
 

Homozygous null embryos do not survive and have mesodermal segments with no cranio-caudal polarity and no epithelial somites develop; caudal sclerotome halves do not condense, the pattern. Mice heterozygous for a knock-out or ENU allele exhibit abnormal metabolic and immunological phenotypes.

 

Gene Ontology (GO) classifications

All GO classifications: (42 annotations)

Process	auditory receptor cell differentiation, auditory receptor cell fate commitment, ...
Component	cytoplasmic vesicle, integral to membrane, ...
Function	calcium ion binding, Notch binding, ...

External Resources: FuncBase

Expression

Literature Summary: (266 records)
Data Summary: Results (868)    Tissues (390)    Images (223)
Theiler Stages: 1, 2, 3, 4, 5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	747
In situ reporter (knock in)	72
Northern blot	5
RT-PCR	41

cDNA source data(44)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(80) Genomic(2) cDNA(49) Primer pair(9) Other(20)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000021037 (Evidence)
Ensembl Gene Model	ENSMUSG00000014773 (Evidence)
Entrez Gene	13388 (Evidence)
UniGene	4875
DFCI	TC1582472, TC1603157, TC1609846
DoTS	DT.527335, DT.94248616
NIA Mouse Gene Index	U037448
Consensus CDS Project	CCDS37452.1
International Mouse Knockout Project Status	Dll1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021037	VEGA Gene Model | MGI Sequence Detail	9519	C57BL/6J
transcript	OTTMUST00000049746	VEGA | MGI Sequence Detail	3581	Not Applicable
polypeptide	OTTMUSP00000023104	VEGA | MGI Sequence Detail	722	Not Applicable

All sequences(34) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(31 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001774	Delta/Serrate/lag-2 (DSL) protein
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR011651	Notch ligand, N-terminal
Protein Ontology	PR:000006523	delta-like protein 1

References

(Earliest) J:28006 Bettenhausen B, et al., Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. Development. 1995 Aug;121(8):2407-18
(Latest) J:194053 Liu B, et al., Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development. 2013 Feb;140(4):780-8
All references(348)

Other accession IDs

MGD-MRK-26099