T2
Gene Detail

Symbol Name ID

T2 brachyury 2 MGI:104658

BioType Conflict

Feature Type

protein coding gene

Genetic Map

Chromosome 17

4.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:8396629-8422728 bp, + strand From VEGA annotation of GRCm38   26100 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:86977  Vertebrate Homology Class
1 mouse; 1 rat

Gene Tree: T2

Alleles and phenotypes

All alleles(3) : Gene trapped(2) Transgenic(1)
 

Homozygotes for mutations at this locus fail to form an organized caudal notochord and die as embryos. Heterozygotes exhibit an abnormal tail phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Process	notochord formation
Component	cellular_component
Function	molecular_function

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(4)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(6) Genomic(2) cDNA(4)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000035219 (Evidence)
Ensembl Gene Model	ENSMUSG00000058159 (Evidence)
Entrez Gene	21331 (Evidence)
UniGene	482744
DFCI	TC1594453
DoTS	DT.55252446
NIA Mouse Gene Index	U129118
Consensus CDS Project	CCDS37434.1
International Mouse Knockout Project Status	T2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035219	VEGA Gene Model | MGI Sequence Detail	26100	C57BL/6J
transcript	OTTMUST00000089735	VEGA | MGI Sequence Detail	1080	Not Applicable
polypeptide	NP_001155304	RefSeq | MGI Sequence Detail	393	C57BL/6

All sequences(17) RefSeq(3) UniProt(2)

Polymorphisms

SNPs(165 from dbSNP Build 128)

References

(Earliest) J:29666 Rennebeck GM, et al., Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice. Dev Biol. 1995 Nov;172(1):206-17
(Latest) J:126311 Wu JI, et al., tint Maps to Mouse Chromosome 6 and May Interact With a Notochordal Enhancer of Brachyury. Genetics. 2007 Oct;177(2):1151-61
All references(19)

Other accession IDs

MGD-MRK-26098