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T2
Gene Detail
Symbol

Name
ID
T2
brachyury 2
MGI:104658
Feature Type
protein coding gene
Genetic Map
Chromosome 17
4.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:8396629-8422728 bp, + strand
From VEGA annotation of GRCm38

  26100 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:86977  Vertebrate Homology Class
1 mouse; 1 rat

Gene Tree: T2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(2) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for mutations at this locus fail to form an organized caudal notochord and die as embryos. Heterozygotes exhibit an abnormal tail phenotype.
 
Interactions
T2 interacts with 8 markers (Mir154, Mir184, Mir378b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process notochord formation
Component cellular_component
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(5)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(7) Genomic(2) cDNA(5)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000035219 (Evidence)
Ensembl Gene ModelENSMUSG00000058159 (Evidence)
Entrez Gene21331 (Evidence)
UniGene482744
DFCITC1594453
DoTSDT.55252446
NIA Mouse Gene IndexU129118
Consensus CDS ProjectCCDS37434.1
International Mouse Knockout Project StatusT2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035219 VEGA Gene Model | MGI Sequence Detail 26100 C57BL/6J ±  kb
transcript OTTMUST00000089735 VEGA | MGI Sequence Detail 1080 Not Applicable 
polypeptide NP_001155304 RefSeq | MGI Sequence Detail 393 C57BL/6 

For the selected sequences
All sequences(39) RefSeq(23) UniProt(4)
Polymorphisms
SNPs within 2kb(378 from dbSNP Build 137)
References
(Earliest) J:29666 Rennebeck GM, et al., Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice. Dev Biol. 1995 Nov;172(1):206-17
(Latest) J:126311 Wu JI, et al., tint Maps to Mouse Chromosome 6 and May Interact With a Notochordal Enhancer of Brachyury. Genetics. 2007 Oct;177(2):1151-61
All references(19)
Other
accession IDs
MGD-MRK-26098

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory