Ambn
Gene Detail

Symbol Name ID

Ambn ameloblastin MGI:104655

Feature Type

protein coding gene

Genetic Map

Chromosome 5

43.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr5:88456011-88468527 bp, + strand From Ensembl annotation of GRCm38   12517 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; pig, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Ambn ± 2 cM)

Gene Tree: Ambn

Human ortholog

AMBN ameloblastin (enamel matrix protein) NCBI Gene ID 258
Human Chr4:71458001-71473005 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygous null mice lack enamel and display abnormal ameloblast and tooth morphology and an increased incidence of dental epithelium derived tumors.

 
Human Diseases Modeled Using Mouse Ambn (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	biomineral tissue development, cell adhesion, ...
Component	extracellular region, proteinaceous extracellular matrix
Function	extracellular matrix structural constituent conferring compression resistance, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (23 records)
Data Summary: Results (86)    Tissues (29)    Images (20)
Theiler Stages: 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	30
Northern blot	16
RT-PCR	40

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(25) cDNA(19) Primer pair(5) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000029288 (Evidence)
Entrez Gene	11698 (Evidence)
UniGene	8437
DFCI	TC1585473, TC1591585
DoTS	DT.60117344, DT.94169515
NIA Mouse Gene Index	U005754
Consensus CDS Project	CCDS51539.1
International Mouse Knockout Project Status	Ambn

Sequences

Length	Strain/Species
genomic	ENSMUSG00000029288	Ensembl Gene Model | MGI Sequence Detail	12517	C57BL/6J
transcript	ENSMUST00000031226	Ensembl | MGI Sequence Detail	1850	Not Applicable
polypeptide	ENSMUSP00000031226	Ensembl | MGI Sequence Detail	407	Not Applicable

All sequences(18) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(12 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007798	Ameloblastin precursor
Protein Ontology	PR:000003985	ameloblastin

References

(Earliest) J:31459 Krebsbach PH, et al., Full-length sequence, localization, and chromosomal mapping of ameloblastin. A novel tooth-specific gene. J Biol Chem. 1996 Feb 23;271(8):4431-5
(Latest) J:193587 Nakagawa E, et al., The novel function of Oct3/4 in mouse tooth development. Histochem Cell Biol. 2012 Mar;137(3):367-76
All references(58)

Other accession IDs

MGD-MRK-26095