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Atp2b1 Gene Detail
Summary
  • Symbol
    Atp2b1
  • Name
    ATPase, Ca++ transporting, plasma membrane 1
  • Synonyms
    2810442I22Rik, E130111D10Rik, PMCA1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104653
    NCBI Gene: 67972
  • Gene Overview
    MyGene.info: ATP2B1
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:98914406-99026143 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 50.97 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    422 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104653
 protein coding gene Chr10:98914359-99026143 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017682
 protein coding gene Chr10:100714338-100831744 (+)
A/J MGP_AJ_G0017661
 protein coding gene Chr10:97082491-97194162 (+)
AKR/J MGP_AKRJ_G0017621
 protein coding gene Chr10:99873472-99984214 (+)
BALB/cJ MGP_BALBcJ_G0017625
 protein coding gene Chr10:97358490-97472064 (+)
C3H/HeJ MGP_C3HHeJ_G0017448
 protein coding gene Chr10:99882583-99997563 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018081
 protein coding gene Chr10:104196681-104320844 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015762
 protein coding gene Chr10:92521680-92628359 (+)
CAST/EiJ MGP_CASTEiJ_G0017011
 protein coding gene Chr10:100009883-100070376 (+)
CBA/J MGP_CBAJ_G0017417
 protein coding gene Chr10:108303172-108420710 (+)
DBA/2J MGP_DBA2J_G0017523
 protein coding gene Chr10:96164229-96276674 (+)
FVB/NJ MGP_FVBNJ_G0017516
 protein coding gene Chr10:95387224-95498846 (+)
LP/J MGP_LPJ_G0017597
 protein coding gene Chr10:101293310-101410361 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017546
 protein coding gene Chr10:109562270-109682279 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018119
 protein coding gene Chr10:99779685-99891681 (+)
PWK/PhJ MGP_PWKPhJ_G0016793
 protein coding gene Chr10:96358758-96417419 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016582
 protein coding gene Chr10:98683251-98800857 (+)
WSB/EiJ MGP_WSBEiJ_G0017071
 protein coding gene Chr10:99835474-99895796 (+)



Homology
more
  • Human Ortholog
    ATP2B1, ATPase plasma membrane Ca2+ transporting 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ATP2B1, ATPase plasma membrane Ca2+ transporting 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PMCA1, PMCA1kb
  • Links
    NCBI Gene ID: 490
    neXtProt AC: NX_P20020
    UniProt: P20020

  • Chr Location
    12q21.33; chr12:89588049-89709353 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    2 with Atp2b1 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    53 phenotypes from 5 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    190
  • Tissues
    145
  • cDNA Data
    22
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019943 Ensembl Gene Model | MGI Sequence Detail 111738 C57BL/6J ±  kb
    transcript ENSMUST00000020107 Ensembl | MGI Sequence Detail 7130 Not Applicable  
    polypeptide ENSMUSP00000020107 Ensembl | MGI Sequence Detail 1220 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 2
      cDNA 24
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-26093, MGI:1915222, MGI:2444822
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 14
      Phenotypes 27
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:271705 Ehara Y, et al., Reduced secretion of parathyroid hormone and hypocalcemia in systemic heterozygous ATP2B1-null hypertensive mice. Hypertens Res. 2018 Sep;41(9):699-707
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/14/2019
    MGI 6.14     		The Jackson Laboratory