Atp2b1 MGI Mouse Gene Detail - MGI:104653 - ATPase, Ca++ transporting, plasma membrane 1

Symbol

Atp2b1
Name

ATPase, Ca++ transporting, plasma membrane 1
Synonyms

2810442I22Rik, E130111D10Rik, PMCA1

Feature Type

protein coding gene
IDs

MGI:104653
NCBI Gene: 67972
Gene Overview

MyGene.info: ATP2B1
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr10:98914630-99026143 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 50.97 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

422 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104653	protein coding gene	Chr10:98914406-99026143 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017682	protein coding gene	Chr10:100714338-100831744 (+)
A/J	MGP_AJ_G0017661	protein coding gene	Chr10:97082491-97194162 (+)
AKR/J	MGP_AKRJ_G0017621	protein coding gene	Chr10:99873472-99984214 (+)
BALB/cJ	MGP_BALBcJ_G0017625	protein coding gene	Chr10:97358490-97472064 (+)
C3H/HeJ	MGP_C3HHeJ_G0017448	protein coding gene	Chr10:99882583-99997563 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018081	protein coding gene	Chr10:104196681-104320844 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015762	protein coding gene	Chr10:92521680-92628359 (+)
CAST/EiJ	MGP_CASTEiJ_G0017011	protein coding gene	Chr10:100009883-100070376 (+)
CBA/J	MGP_CBAJ_G0017417	protein coding gene	Chr10:108303172-108420710 (+)
DBA/2J	MGP_DBA2J_G0017523	protein coding gene	Chr10:96164229-96276674 (+)
FVB/NJ	MGP_FVBNJ_G0017516	protein coding gene	Chr10:95387224-95498846 (+)
LP/J	MGP_LPJ_G0017597	protein coding gene	Chr10:101293310-101410361 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017546	protein coding gene	Chr10:109562270-109682279 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018119	protein coding gene	Chr10:99779685-99891681 (+)
PWK/PhJ	MGP_PWKPhJ_G0016793	protein coding gene	Chr10:96358758-96417419 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016582	protein coding gene	Chr10:98683251-98800857 (+)
WSB/EiJ	MGP_WSBEiJ_G0017071	protein coding gene	Chr10:99835474-99895796 (+)

Human Ortholog

ATP2B1, ATPase plasma membrane Ca2+ transporting 1

Vertebrate Orthologs

9

Human Ortholog

ATP2B1, ATPase plasma membrane Ca2+ transporting 1
Orthology source: HomoloGene, HGNC
Synonyms

PMCA1, PMCA1kb
Links

HGNC:814

NCBI Gene ID: 490

neXtProt AC: NX_P20020

UniProt: P20020
Chr Location

12q21.33; chr12:89588049-89709353 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 55597
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: ATP2B1
Gene Tree

Atp2b1

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

26 phenotypes from 4 alleles in 5 genetic backgrounds
31 phenotypes from multigenic genotypes
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

1
Gene trapped

16
Targeted

7
Transgenic

1
Genomic Mutations

1 involving Atp2b1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation. Cultured blastocysts form outgrowths with apparent inner cell mass but no trophectoderm or primitive endoderm cells.

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All GO Annotations

60
GO References

14

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

204
Tissues

158
cDNA Data

22
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ATP2B1

Xenbase atp2b1

ZFIN atp2b1a

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Atp2b1 interacts with 425 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

99
RefSeq

16
UniProt

13
CCDS

CCDS24145.1

Ensembl

ENSMUSG00000019943 (Evidence)
NCBI Gene

67972

			Length	Strain/Species	Flank
genomic	67972	NCBI Gene Model \| MGI Sequence Detail	111514	C57BL/6J	± kb
transcript	NM_001359507	RefSeq \| MGI Sequence Detail	7300	C57BL/6
polypeptide	G5E829	UniProt \| EBI \| MGI Sequence Detail	1220	Not Applicable

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UniProt

13 Sequences
Protein Ontology

PR:000004445 plasma membrane calcium-transporting ATPase 1

(term hierarchy)
EC

7.2.2.10
InterPro Domains

IPR006068 Cation-transporting P-type ATPase, C-terminal

IPR004014 Cation-transporting P-type ATPase, N-terminal

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR030320 Plasma membrane calcium-transporting ATPase 1

IPR022141 Plasma membrane calcium transporting P-type ATPase, C-terminal

IPR001757 P-type ATPase

IPR008250 P-type ATPase, A domain superfamily

IPR023299 P-type ATPase, cytoplasmic domain N

IPR018303 P-type ATPase, phosphorylation site

IPR006408 P-type ATPase, subfamily IIB

IPR023298 P-type ATPase, transmembrane domain superfamily

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All nucleic 30

Genomic 2

cDNA 24

Primer pair 4

Microarray probesets 5

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MGD-MRK-26093, MGI:1915222, MGI:2444822

Summaries

All 73

Developmental Gene Expression 10

Diseases 1

Gene Ontology 14

Phenotypes 29
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:271705 Ehara Y, et al., Reduced secretion of parathyroid hormone and hypocalcemia in systemic heterozygous ATP2B1-null hypertensive mice. Hypertens Res. 2018 Sep;41(9):699-707

TSS for Atp2b1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95515	Chr10:98914639-98914721 (+)	50 bp
Tssr95516	Chr10:98915117-98915172 (+)	515 bp
Tssr95517	Chr10:98915181-98915192 (+)	557 bp
Tssr95526	Chr10:98990497-98990512 (+)	75,875 bp
Tssr95532	Chr10:99023408-99023428 (+)	108,788 bp
Tssr95533	Chr10:99023437-99023457 (+)	108,817 bp
Tssr95534	Chr10:99023675-99023687 (+)	109,051 bp
Tssr95535	Chr10:99025411-99025421 (+)	110,786 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 12/10/2019 MGI 6.14