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Atp2b1 Gene Detail
Summary
  • Symbol
    Atp2b1
  • Name
    ATPase, Ca++ transporting, plasma membrane 1
  • Synonyms
    2810442I22Rik, E130111D10Rik, PMCA1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104653
    NCBI Gene: 67972
  • Gene Overview
    MyGene.info: ATP2B1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr10:98914406-99026143 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      111738 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 50.97 cM, cytoband C3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ATP2B1, ATPase plasma membrane Ca2+ transporting 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ATP2B1, ATPase plasma membrane Ca2+ transporting 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PMCA1, PMCA1kb
  • Links
    NCBI Gene ID: 490
    neXtProt AC: NX_P20020
    UniProt: P20020

  • Chr Location
    12q21.33; chr12:89588049-89709353 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    190
  • Tissues
    145
  • cDNA Data
    21
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019943 Ensembl Gene Model | MGI Sequence Detail 111738 C57BL/6J ±  kb
    transcript ENSMUST00000020107 Ensembl | MGI Sequence Detail 7130 Not Applicable  
    polypeptide ENSMUSP00000020107 Ensembl | MGI Sequence Detail 1220 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      422 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 2
      cDNA 23
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-26093, MGI:1915222, MGI:2444822
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 9
      Gene Ontology 7
      Phenotypes 25
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:256009 Korthals M, et al., A complex of Neuroplastin and Plasma Membrane Ca(2+) ATPase controls T cell activation. Sci Rep. 2017 Aug 21;7(1):8358
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory