Atp2b1 MGI Mouse Gene Detail - MGI:104653 - ATPase, Ca++ transporting, plasma membrane 1

Atp2b1 Gene Detail

Symbol

Atp2b1
Name

ATPase, Ca++ transporting, plasma membrane 1
Synonyms

2810442I22Rik, E130111D10Rik, PMCA1

Feature Type

protein coding gene
IDs

MGI:104653
NCBI Gene: 67972
Gene Overview

MyGene.info: ATP2B1

Sequence Map

Chr10:98914406-99026143 bp, + strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

111738 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 50.97 cM, cytoband C3
Mapping Data

2 experiments

Human Ortholog

ATP2B1, ATPase plasma membrane Ca2+ transporting 1

Vertebrate Orthologs

9

Human Ortholog

ATP2B1, ATPase plasma membrane Ca2+ transporting 1
Orthology source: HomoloGene, HGNC
Synonyms

PMCA1, PMCA1kb
Links

HGNC:814

NCBI Gene ID: 490

neXtProt AC: NX_P20020

UniProt: P20020
Chr Location

12q21.33; chr12:89588049-89709353 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 55597
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: ATP2B1
Gene Tree

Atp2b1

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Phenotype Summary

25 phenotypes from 4 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

1
Gene trapped

16
Targeted

5
Genomic Mutations

1 involving Atp2b1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available

Homozygous null mice display embryonic lethality.

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All GO Annotations

38
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

166
Tissues

125
cDNA Data

15
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ATP2B1

ZFIN atp2b1a

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Atp2b1 interacts with 425 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

74
RefSeq

15
UniProt

13
CCDS

CCDS24145.1

Ensembl

ENSMUSG00000019943 (Evidence)
NCBI Gene

67972

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019943	Ensembl Gene Model \| MGI Sequence Detail	111738	C57BL/6J	± kb
transcript	ENSMUST00000020107	Ensembl \| MGI Sequence Detail	7130	Not Applicable
polypeptide	ENSMUSP00000020107	Ensembl \| MGI Sequence Detail	1220	Not Applicable

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SNPs within 2kb

422 from dbSNP Build 142

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UniProt

13 Sequences
Protein Ontology

PR:000004445 plasma membrane calcium-transporting ATPase 1

(term hierarchy)
EC

3.6.3.8
InterPro Domains

IPR006068 Cation-transporting P-type ATPase, C-terminal

IPR004014 Cation-transporting P-type ATPase, N-terminal

IPR023214 HAD-like domain

IPR030320 Plasma membrane calcium-transporting ATPase 1

IPR022141 Plasma membrane calcium transporting P-type ATPase, C-terminal

IPR001757 P-type ATPase

IPR008250 P-type ATPase, A domain

IPR023299 P-type ATPase, cytoplasmic domain N

IPR018303 P-type ATPase, phosphorylation site

IPR006408 P-type ATPase, subfamily IIB

IPR023298 P-type ATPase, transmembrane domain

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All nucleic 21

Genomic 2

cDNA 17

Primer pair 2

Microarray probesets 5

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MGD-MRK-26093, MGI:1915222, MGI:2444822

Summaries

All 64

Developmental Gene Expression 9

Gene Ontology 7

Phenotypes 24
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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