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Atp2b1 Gene Detail
Summary
  • Symbol
    Atp2b1
  • Name
    ATPase, Ca++ transporting, plasma membrane 1
  • Synonyms
    2810442I22Rik, E130111D10Rik, PMCA1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104653
    NCBI Gene: 67972
  • Gene Overview
    MyGene.info: ATP2B1
Location & Maps
more
  • Sequence Map
    Chr10:98915152-99026143 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      110992 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 50.97 cM, cytoband C3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ATP2B1, ATPase plasma membrane Ca2+ transporting 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ATP2B1, ATPase plasma membrane Ca2+ transporting 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PMCA1, PMCA1kb
  • Links
    NCBI Gene ID: 490
    neXtProt AC: NX_P20020

  • Chr Location
    12q21.3; chr12:89588049-89709353 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    1
  • Gene trapped
    16
  • Targeted
    4
  • Genomic Mutations
    1 involving Atp2b1
  • Incidental Mutations
Homozygous null mice display embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019943 Ensembl Gene Model | MGI Sequence Detail 110992 C57BL/6J ±  kb
transcript ENSMUST00000020107 Ensembl | MGI Sequence Detail 7130 Not Applicable  
polypeptide ENSMUSP00000020107 Ensembl | MGI Sequence Detail 1220 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    422 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000004445 plasma membrane calcium-transporting ATPase 1
  • EC
  • InterPro Domains
    IPR006068 Cation-transporting P-type ATPase, C-terminal
    IPR004014 Cation-transporting P-type ATPase, N-terminal
    IPR023214 HAD-like domain
    IPR030320 Plasma membrane calcium-transporting ATPase 1
    IPR030319 Plasma membrane calcium-transporting ATPase 1/4
    IPR022141 Plasma membrane calcium transporting P-type ATPase, C-terminal
    IPR001757 P-type ATPase
    IPR008250 P-type ATPase, A domain
    IPR023299 P-type ATPase, cytoplasmic domain N
    IPR018303 P-type ATPase, phosphorylation site
    IPR006408 P-type ATPase, subfamily IIB
    IPR023298 P-type ATPase, transmembrane domain
Molecular
Reagents
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  • All nucleic 21
    Genomic 2
    cDNA 17
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-26093, MGI:1915222, MGI:2444822
References
more
  • Summaries
    All 56
    Developmental Gene Expression 8
    Gene Ontology 7
    Phenotypes 22
  • Earliest
    J:24419 Du Y, et al., The mouse plasma membrane Ca2+ pump isoform 1 promoter: cloning and characterization. Arch Biochem Biophys. 1995 Jan 10;316(1):302-10
  • Latest
    J:216570 Brini M, et al., The plasma membrane calcium pump in health and disease. FEBS J. 2013 Nov;280(21):5385-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory