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Atp2b1 Gene Detail
Summary
  • Symbol
    Atp2b1
  • Name
    ATPase, Ca++ transporting, plasma membrane 1
  • Synonyms
    2810442I22Rik, E130111D10Rik, PMCA1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104653
    NCBI Gene: 67972
  • Alliance
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:98750268-98862005 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 50.97 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    421 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104653
protein coding gene Chr10:98750243-98862005 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017682
protein coding gene Chr10:100714338-100831744 (+)
A/J MGP_AJ_G0017661
protein coding gene Chr10:97082491-97194162 (+)
AKR/J MGP_AKRJ_G0017621
protein coding gene Chr10:99873472-99984214 (+)
BALB/cJ MGP_BALBcJ_G0017625
protein coding gene Chr10:97358490-97472064 (+)
C3H/HeJ MGP_C3HHeJ_G0017448
protein coding gene Chr10:99882583-99997563 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018081
protein coding gene Chr10:104196681-104320844 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015762
protein coding gene Chr10:92521680-92628359 (+)
CAST/EiJ MGP_CASTEiJ_G0017011
protein coding gene Chr10:100009883-100070376 (+)
CBA/J MGP_CBAJ_G0017417
protein coding gene Chr10:108303172-108420710 (+)
DBA/2J MGP_DBA2J_G0017523
protein coding gene Chr10:96164229-96276674 (+)
FVB/NJ MGP_FVBNJ_G0017516
protein coding gene Chr10:95387224-95498846 (+)
LP/J MGP_LPJ_G0017597
protein coding gene Chr10:101293310-101410361 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017546
protein coding gene Chr10:109562270-109682279 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018119
protein coding gene Chr10:99779685-99891681 (+)
PWK/PhJ MGP_PWKPhJ_G0016793
protein coding gene Chr10:96358758-96417419 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016582
protein coding gene Chr10:98683251-98800857 (+)
WSB/EiJ MGP_WSBEiJ_G0017071
protein coding gene Chr10:99835474-99895796 (+)



Homology
more
  • Human Ortholog
    ATP2B1, ATPase plasma membrane Ca2+ transporting 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP2B1, ATPase plasma membrane Ca2+ transporting 1
  • Synonyms
    PMCA1, PMCA1kb
  • Links
    NCBI Gene ID: 490
    neXtProt AC: NX_P20020
    UniProt: P20020

  • Chr Location
    12q21.33; chr12:89588049-89709353 (-)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 4 alleles in 5 genetic backgrounds
    31 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation. Cultured blastocysts form outgrowths with apparent inner cell mass but no trophectoderm or primitive endoderm cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019943 Ensembl Gene Model | MGI Sequence Detail 111738 C57BL/6J ±  kb
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      13 Sequences
    • Protein Ontology
      PR:000004445 plasma membrane calcium-transporting ATPase 1
    • EC
    • InterPro Domains
      IPR006068 Cation-transporting P-type ATPase, C-terminal
      IPR004014 Cation-transporting P-type ATPase, N-terminal
      IPR036412 HAD-like superfamily
      IPR023214 HAD superfamily
      IPR030320 Plasma membrane calcium-transporting ATPase 1
      IPR030322 Plasma membrane calcium-transporting ATPase 2
      IPR034304 Plasma membrane calcium-transporting ATPase 4
      IPR022141 Plasma membrane calcium transporting P-type ATPase, C-terminal
      IPR001757 P-type ATPase
      IPR008250 P-type ATPase, A domain superfamily
      IPR023299 P-type ATPase, cytoplasmic domain N
      IPR044492 P-type ATPase, haloacid dehalogenase domain
      IPR018303 P-type ATPase, phosphorylation site
      IPR006408 P-type ATPase, subfamily IIB
      IPR023298 P-type ATPase, transmembrane domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 2
      cDNA 24
      Primer pair 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-26093, MGI:1915222, MGI:2444822
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 15
      Phenotypes 31
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:302967 Korthals M, et al., Plasma membrane Ca(2+) ATPase 1 (PMCA1) but not PMCA4 is critical for B-cell development and Ca(2+) homeostasis in mice. Eur J Immunol. 2021 Mar;51(3):594-602

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/10/2022
    MGI 6.19
    The Jackson Laboratory