Capzb
Gene Detail

Symbol Name ID

Capzb capping protein (actin filament) muscle Z-line, beta MGI:104652

Synonyms

1700120C01Rik, Cappb1, CPB1, CPB2, CPbeta1, CPbeta2

Feature Type

protein coding gene

Genetic Map

Chromosome 4

70.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr4:139192899-139291818 bp, + strand From VEGA annotation of GRCm38   98920 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3620  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: actin-capping protein beta chain
Gene Tree: Capzb

Human homologs

Human Homolog		CAPZB, capping protein (actin filament) muscle Z-line, beta
NCBI Gene ID		832
neXtProt AC		NX_P47756
Human Synonyms		CAPB, CAPPB, CAPZ
Human Chr (Location)		1p36.1; chr1:19665267-19812066 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(174) : Targeted(1) Gene trapped(173)

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	actin cytoskeleton organization, actin filament capping, ...
Component	acrosomal vesicle, cortical cytoskeleton, ...
Function	actin binding, actin filament binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (25)    Tissues (5)    Images (9)
Theiler Stages: 22, 23, 26, 28

Assay Type	Results
RNA in situ	7
RT-PCR	18

cDNA source data(318)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(320) cDNA(319) Primer pair(1)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000009900 (Evidence)
Ensembl Gene Model	ENSMUSG00000028745 (Evidence)
Entrez Gene	12345 (Evidence)
UniGene	2945
DFCI	TC1573225, TC1586197, TC1618613, TC1689359, TC1763867, TC1779304
DoTS	DT.101404567, DT.101404568, DT.110816010, DT.55119551, DT.94412695, DT.94412707, DT.97358588, DT.99864875, DT.99864878
NIA Mouse Gene Index	U005012
Consensus CDS Project	CCDS18841.1, CCDS18842.1
International Mouse Knockout Project Status	Capzb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009900	VEGA Gene Model | MGI Sequence Detail	98920	C57BL/6J
transcript	OTTMUST00000022958	VEGA | MGI Sequence Detail	1390	Not Applicable
polypeptide	OTTMUSP00000010481	VEGA | MGI Sequence Detail	301	Not Applicable

All sequences(122) RefSeq(8) UniProt(9)

Polymorphisms

SNPs(594 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019771	F-actin capping protein, beta subunit, conserved site
InterPro	IPR001698	WASH complex, F-actin capping protein, beta subunit
Protein Ontology	PR:000005032	F-actin-capping protein subunit beta

References

(Earliest) J:20868 Schafer DA, et al., Differential localization and sequence analysis of capping protein beta-subunit isoforms of vertebrates. J Cell Biol. 1994 Oct;127(2):453-65
(Latest) J:183650 Yang FH, et al., Reduced cardiac CapZ protein protects hearts against acute ischemia-reperfusion injury and enhances preconditioning. J Mol Cell Cardiol. 2012 Mar;52(3):761-72
All references(58)

Other accession IDs

MGD-MRK-26092, MGI:1923909, MGI:2140240