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Capzb
Gene Detail
Symbol

Name
ID
Capzb
capping protein (actin filament) muscle Z-line, beta
MGI:104652
Synonyms
1700120C01Rik, Cappb1, CPB1, CPB2, CPbeta1, CPbeta2
Feature Type
protein coding gene
Genetic Map
Chromosome 4
70.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:139192899-139291818 bp, + strand
From VEGA annotation of GRCm38

  98920 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3620  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: CAPZB
Protein SuperFamily: actin-capping protein beta chain
Gene Tree: Capzb

Human
homologs
CAPZB, capping protein (actin filament) muscle Z-line, beta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 832
neXtProt AC: NX_P47756

Human Synonyms: CAPB, CAPPB, CAPZ

Human Chr (Location): 1p36.1; chr1:19338773-19485641 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(175) : Gene trapped(173) Targeted(2)
Genomic Mutations involving Capzb (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Capzb interacts with 143 markers (Mir7-1, Mir16-2, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process actin cytoskeleton organization, actin filament capping, ...
Component acrosomal vesicle, actin filament, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (25)    Tissues (6)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
RT-PCR 18
cDNA source data(319)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase capzb    NEW 
Molecular
reagents
All nucleic(321) cDNA(320) Primer pair(1)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000009900 (Evidence)
Ensembl Gene Model ENSMUSG00000028745 (Evidence)
Entrez Gene 12345 (Evidence)
UniGene 2945
DFCI TC1586197, TC1573225, TC1779304, TC1618613, TC1763867, TC1689359
DoTS DT.101404567, DT.55119551, DT.99864878, DT.110816010, DT.101404568, DT.99864875, DT.94412695, DT.97358588, DT.94412707
NIA Mouse Gene Index U005012
Consensus CDS Project CCDS18841.1, CCDS18842.1, CCDS71503.1, CCDS71504.1
International Mouse Phenotyping Consortium Status Capzb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009900 VEGA Gene Model | MGI Sequence Detail 98920 C57BL/6J ±  kb
transcript OTTMUST00000022958 VEGA | MGI Sequence Detail 1390 Not Applicable 
polypeptide OTTMUSP00000010481 VEGA | MGI Sequence Detail 301 Not Applicable 

For the selected sequences
All sequences(124) RefSeq(10) UniProt(9)
Polymorphisms
SNPs within 2kb(813 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019771 F-actin capping protein, beta subunit, conserved site
InterPro IPR001698 WASH complex, F-actin capping protein, beta subunit
Protein Ontology PR:000005032 F-actin-capping protein subunit beta
References
(Earliest) J:20868 Schafer DA, et al., Differential localization and sequence analysis of capping protein beta-subunit isoforms of vertebrates. J Cell Biol. 1994 Oct;127(2):453-65
(Latest) J:208829 Fujiwara I, et al., Capping protein regulatory cycle driven by CARMIL and V-1 may promote actin network assembly at protruding edges. Proc Natl Acad Sci U S A. 2014 May 13;111(19):E1970-9
All references(61)
Other
accession IDs
MGD-MRK-26092, MGI:1923909, MGI:2140240

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory