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Capzb
Gene Detail
 Symbol
Name
ID
Capzb
capping protein (actin filament) muscle Z-line, beta
MGI:104652
Synonyms 1700120C01Rik, Cappb1, CPB1, CPB2, CPbeta1, CPbeta2
Feature Type protein coding gene
Genetic Map
Chromosome 4
70.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:139192899-139291818 bp, + strand
From VEGA annotation of GRCm38

  98920 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3620  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: actin-capping protein beta chain
Gene Tree: Capzb

Human
homologs
Human Homolog CAPZB, capping protein (actin filament) muscle Z-line, beta
NCBI Gene ID 832
neXtProt AC  NX_P47756
Human Synonyms  CAPB, CAPPB, CAPZ
Human Chr (Location)  1p36.1; chr1:19338773-19485641 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(174) : Gene trapped(173) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Capzb interacts with 143 markers (Mir7-1, Mir16-2, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process actin cytoskeleton organization, actin filament capping, ...
Component acrosomal vesicle, cortical cytoskeleton, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (25)    Tissues (6)    Images (9)
Theiler Stages: 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 7
RT-PCR 18
cDNA source data(319)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(321) cDNA(320) Primer pair(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000009900 (Evidence)
Ensembl Gene ModelENSMUSG00000028745 (Evidence)
Entrez Gene12345 (Evidence)
UniGene2945
DFCITC1573225, TC1586197, TC1618613, TC1689359, TC1763867, TC1779304
DoTSDT.101404567, DT.101404568, DT.110816010, DT.55119551, DT.94412695, DT.94412707, DT.97358588, DT.99864875, DT.99864878
NIA Mouse Gene IndexU005012
Consensus CDS ProjectCCDS18841.1, CCDS18842.1, CCDS71503.1, CCDS71504.1
International Mouse Knockout Project StatusCapzb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009900 VEGA Gene Model | MGI Sequence Detail 98920 C57BL/6J ±  kb
transcript OTTMUST00000022958 VEGA | MGI Sequence Detail 1390 Not Applicable 
polypeptide OTTMUSP00000010481 VEGA | MGI Sequence Detail 301 Not Applicable 

For the selected sequences
All sequences(125) RefSeq(12) UniProt(8)
Polymorphisms SNPs within 2kb(813 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019771 F-actin capping protein, beta subunit, conserved site
InterPro IPR001698 WASH complex, F-actin capping protein, beta subunit
Protein Ontology PR:000005032 F-actin-capping protein subunit beta
References (Earliest) J:20868 Schafer DA, et al., Differential localization and sequence analysis of capping protein beta-subunit isoforms of vertebrates. J Cell Biol. 1994 Oct;127(2):453-65
(Latest) J:183650 Yang FH, et al., Reduced cardiac CapZ protein protects hearts against acute ischemia-reperfusion injury and enhances preconditioning. J Mol Cell Cardiol. 2012 Mar;52(3):761-72
All references(58)
Other
accession IDs
MGD-MRK-26092, MGI:1923909, MGI:2140240

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory