Cnr2
Gene Detail

Symbol Name ID

Cnr2 cannabinoid receptor 2 (macrophage) MGI:104650

Synonyms

cannabinoid receptor 2 (spleen), CB2, CB2-R

Feature Type

protein coding gene

Genetic Map

Chromosome 4

68.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:135895394-135920207 bp, + strand From VEGA annotation of GRCm38   24814 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Cnr2 ± 2 cM)

Protein SuperFamily: cannabinoid receptor 2
Gene Tree: Cnr2

Human ortholog

CNR2 cannabinoid receptor 2 (macrophage) NCBI Gene ID 1269
Human Synonyms: CB2, CB-2, CX5
Human Chr1:24200460-24239817 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Macrophages from homozygous mutant animals are resistant to the inhibitory effects of delta9-Tetrahydrocannabinol. Alopecia is seen in some but not all homozygotes.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	behavior, cannabinoid signaling pathway, ...
Component	cell projection, dendrite, ...
Function	cannabinoid receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (170)    Tissues (78)    Images (16)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	43
RT-PCR	127

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(5) cDNA(13) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000009846 (Evidence)
Ensembl Gene Model	ENSMUSG00000062585 (Evidence)
Entrez Gene	12802 (Evidence)
UniGene	297251
DFCI	TC1584973
DoTS	DT.101359438, DT.40182793
NIA Mouse Gene Index	U004954
Consensus CDS Project	CCDS18793.1
International Mouse Knockout Project Status	Cnr2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009846	VEGA Gene Model | MGI Sequence Detail	24814	C57BL/6J
transcript	OTTMUST00000022818	VEGA | MGI Sequence Detail	3867	Not Applicable
polypeptide	OTTMUSP00000010409	VEGA | MGI Sequence Detail	347	Not Applicable

All sequences(25) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(107 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002230	Cannabinoid receptor
InterPro	IPR001551	Cannabinoid receptor, type 2
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001126	cannabinoid receptor 2

References

(Earliest) J:46599 Munro S, et al., Molecular characterization of a peripheral receptor for cannabinoids [see comments]. Nature. 1993 Sep 2;365(6441):61-5
(Latest) J:194099 Karmaus PW, et al., Delta9-tetrahydrocannabinol impairs the inflammatory response to influenza infection: role of antigen-presenting cells and the cannabinoid receptors 1 and 2. Toxicol Sci. 2013 Feb;131(2):419-33
All references(96)

Other accession IDs

MGD-MRK-26090