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Cox6a2
Gene Detail
Symbol

Name
ID
Cox6a2
cytochrome c oxidase subunit VIa polypeptide 2
MGI:104649
Synonyms
COXVIaH, subunit VIaH (heart-type), VIaH
Feature Type
protein coding gene
Genetic Map
Chromosome 7
70.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:128205436-128206366 bp, - strand
From Ensembl annotation of GRCm38

  931 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38020  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: COX6A2
Protein SuperFamily: cytochrome-c oxidase, subunit VIa
Gene Tree: Cox6a2

Human
homologs
COX6A2, cytochrome c oxidase subunit VIa polypeptide 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1339
neXtProt AC: NX_Q02221

Human Synonyms: COX6AH, COXVIAH

Human Chr (Location): 16p11.12; chr16:31427731-31428428 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation exhibit cardiac dysfunction as a result of abnormal ventricular filling or diastolic dysfunction under maximal cardiac load.
 
Interactions
Cox6a2 interacts with 20 markers (Mir18, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Component membrane, mitochondrial inner membrane, ...
Function cytochrome-c oxidase activity
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (170)    Tissues (105)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 157
RT-PCR 2
RNase protection 11
cDNA source data(162)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cox6a2    NEW 
Molecular
reagents
All nucleic(167) Genomic(4) cDNA(162) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000030785 (Evidence)
Entrez Gene 12862 (Evidence)
UniGene 43824
DFCI TC1688350, TC1575772
NIA Mouse Gene Index U029318
Consensus CDS Project CCDS21891.1
International Mouse Phenotyping Consortium Status Cox6a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030785 Ensembl Gene Model | MGI Sequence Detail 931 C57BL/6J ±  kb
transcript ENSMUST00000033049 Ensembl | MGI Sequence Detail 658 Not Applicable 
polypeptide ENSMUSP00000033049 Ensembl | MGI Sequence Detail 97 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(53 from dbSNP Build 137)    SNPs within 2kb including multiple locations(57)
Protein-related
information
ResourceIDDescription
InterPro IPR001349 Cytochrome c oxidase, subunit VIa
InterPro IPR018507 Cytochrome c oxidase, subunit VIa, conserved site
Protein Ontology PR:000005782 cytochrome c oxidase subunit 6A2, mitochondrial
References
(Earliest) J:29714 Wan B, et al., Structural characterization and regulatory element analysis of the heart isoform of cytochrome c oxidase VIa. J Biol Chem. 1995 Nov 3;270(44):26433-40
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(38)
Other
accession IDs
MGD-MRK-26089

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory