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Il15ra Gene Detail
Summary
  • Symbol
    Il15ra
  • Name
    interleukin 15 receptor, alpha chain
  • Feature Type
    protein coding gene
  • IDs
    MGI:104644
    NCBI Gene: 16169
Location & Maps
more
  • Sequence Map
    Chr2:11705290-11734317 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29028 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 8.97 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    IL15RA, interleukin 15 receptor subunit alpha
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL15RA, interleukin 15 receptor subunit alpha
    Orthology source: HomoloGene
  • Synonyms
    CD215
  • Links
    NCBI Gene ID: 3601
    neXtProt AC: NX_Q13261

  • Chr Location
    10p15.1; chr10:5948900-5978634 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 5 alleles in 8 genetic backgrounds
    1 phenotype from multigenic genotypes
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutation of this gene results in absence of NK cell production in spleen and bone marrow.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011178 VEGA Gene Model | MGI Sequence Detail 29028 C57BL/6J ±  kb
transcript OTTMUST00000093526 VEGA | MGI Sequence Detail 1600 Not Applicable  
polypeptide OTTMUSP00000051907 VEGA | MGI Sequence Detail 263 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    166 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000008981 interleukin-15 receptor subunit alpha
  • PDB
  • InterPro Domains
    IPR000436 Sushi/SCR/CCP domain
Molecular
Reagents
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  • All nucleic 33
    cDNA 33

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-26082, MGI:2138805
References
more
  • Summaries
    All 109
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 65
  • Earliest
    J:28202 Giri JG, et al., Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. 1995 Aug 1;14(15):3654-63
  • Latest
    J:233785 Dupaul-Chicoine J, et al., The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity. Immunity. 2015 Oct 20;43(4):751-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory