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Il15ra Gene Detail
Summary
  • Symbol
    Il15ra
  • Name
    interleukin 15 receptor, alpha chain
  • Feature Type
    protein coding gene
  • IDs
    MGI:104644
    NCBI Gene: 16169
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:11705169-11733985 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 8.97 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104644
protein coding gene Chr2:11705169-11734317 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025347
protein coding gene Chr2:9125852-9157985 (+)
A/J MGP_AJ_G0025324
protein coding gene Chr2:8712717-8774766 (+)
AKR/J MGP_AKRJ_G0025293
protein coding gene Chr2:9018726-9084811 (+)
BALB/cJ MGP_BALBcJ_G0025320
protein coding gene Chr2:8726896-8764548 (+)
C3H/HeJ MGP_C3HHeJ_G0025080
protein coding gene Chr2:8932502-8994961 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025762
protein coding gene Chr2:9376870-9411254 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023177
protein coding gene Chr2:8171238-8202516 (+)
CAST/EiJ MGP_CASTEiJ_G0024543
protein coding gene Chr2:9001759-9034898 (+)
CBA/J MGP_CBAJ_G0025059
protein coding gene Chr2:9769595-9802551 (+)
DBA/2J MGP_DBA2J_G0025191
protein coding gene Chr2:8627142-8688254 (+)
FVB/NJ MGP_FVBNJ_G0025153
protein coding gene Chr2:8579409-8609237 (+)
LP/J MGP_LPJ_G0025277
protein coding gene Chr2:9006103-9077315 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025185
protein coding gene Chr2:9648087-9677983 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025820
protein coding gene Chr2:8974144-9004705 (+)
PWK/PhJ MGP_PWKPhJ_G0024294
protein coding gene Chr2:8635380-8666560 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024094
protein coding gene Chr2:8969541-9003745 (+)
WSB/EiJ MGP_WSBEiJ_G0024613
protein coding gene Chr2:9041275-9071675 (+)



Homology
more
  • Human Ortholog
    IL15RA, interleukin 15 receptor subunit alpha
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL15RA, interleukin 15 receptor subunit alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD215
  • Links
    NCBI Gene ID: 3601
    neXtProt AC: NX_Q13261
    UniProt: Q13261

  • Chr Location
    10p15.1; chr10:5948897-5978741 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 5 alleles in 8 genetic backgrounds
    1 phenotype from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutation of this gene results in absence of NK cell production in spleen and bone marrow.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16169 NCBI Gene Model | MGI Sequence Detail 28817 C57BL/6J ±  kb
    transcript NM_133836 RefSeq | MGI Sequence Detail 1717 C57BL/6  
    polypeptide Q60819 UniProt | EBI | MGI Sequence Detail 263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 34

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-26082, MGI:2138805
    References
    more
    • Summaries
      All 121
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 71
    • Earliest
      J:28202 Giri JG, et al., Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. 1995 Aug 1;14(15):3654-63
    • Latest
      J:257072 Loro E, et al., IL15RA is required for osteoblast function and bone mineralization. Bone. 2017 Oct;103:20-30

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory