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Pdcd2
Gene Detail
Symbol

Name
ID
Pdcd2
programmed cell death 2
MGI:104643
Synonyms
RP-8
Feature Type
protein coding gene
Genetic Map
Chromosome 17
8.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:15519208-15527301 bp, - strand
From VEGA annotation of GRCm38

  8094 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1951  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: programmed cell death protein 2 homolog
Gene Tree: Pdcd2

Human
homologs
Human Homolog PDCD2, programmed cell death 2
NCBI Gene ID 5134
neXtProt AC  NX_Q16342
Human Synonyms  RP8, ZMYND7
Human Chr (Location)  6q27; chr6:170575572-170584692 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display embryonic lethality before implantation with most arresting before the blastocyst satge.
 
Interactions
Pdcd2 interacts with 132 markers (Mir1b, Mir15a, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process apoptotic process
Component cytoplasm, extracellular vesicular exosome, ...
Function DNA binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (36)    Tissues (8)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 36
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) Genomic(3) cDNA(6) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000032972 (Evidence)
Ensembl Gene ModelENSMUSG00000014771 (Evidence)
Entrez Gene18567 (Evidence)
NIA Mouse Gene IndexU037450
Consensus CDS ProjectCCDS28413.1
International Mouse Knockout Project StatusPdcd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032972 VEGA Gene Model | MGI Sequence Detail 8094 C57BL/6J ±  kb
transcript OTTMUST00000082215 VEGA | MGI Sequence Detail 1120 Not Applicable 
polypeptide OTTMUSP00000044046 VEGA | MGI Sequence Detail 343 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007320 Programmed cell death protein 2, C-terminal
InterPro IPR002893 Zinc finger, MYND-type
Protein Ontology PR:000012453 programmed cell death protein 2
References
(Earliest) J:23943 Vaux DL, et al., Cloning of mouse RP-8 cDNA and its expression during apoptosis of lymphoid and myeloid cells. DNA Cell Biol. 1995 Mar;14(3):189-93
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)
Other
accession IDs
MGD-MRK-26081, MGI:2146889

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory