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Pdcd2
Gene Detail
Symbol

Name
ID
Pdcd2
programmed cell death 2
MGI:104643
Synonyms
RP-8
Feature Type
protein coding gene
Genetic Map
Chromosome 17
8.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:15519208-15527301 bp, - strand
From VEGA annotation of GRCm38

  8094 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1951  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PDCD2
Protein SuperFamily: programmed cell death protein 2 homolog
Gene Tree: Pdcd2

Human
homologs
PDCD2, programmed cell death 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5134
neXtProt AC: NX_Q16342

Human Synonyms: RP8, ZMYND7

Human Chr (Location): 6q27; chr6:170575572-170584774 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display embryonic lethality before implantation with most arresting before the blastocyst satge.
 
Interactions
Pdcd2 interacts with 132 markers (Mir1b, Mir15a, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component cytoplasm, extracellular exosome, ...
Function DNA binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (36)    Tissues (8)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 36
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pdcd2 ; ZFIN pdcd2    NEW 
Molecular
reagents
All nucleic(10) Genomic(3) cDNA(6) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000032972 (Evidence)
Ensembl Gene Model ENSMUSG00000014771 (Evidence)
Entrez Gene 18567 (Evidence)
Consensus CDS Project CCDS28413.1
International Mouse Phenotyping Consortium Status Pdcd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032972 VEGA Gene Model | MGI Sequence Detail 8094 C57BL/6J ±  kb
transcript OTTMUST00000082215 VEGA | MGI Sequence Detail 1120 Not Applicable 
polypeptide OTTMUSP00000044046 VEGA | MGI Sequence Detail 343 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007320 Programmed cell death protein 2, C-terminal
InterPro IPR002893 Zinc finger, MYND-type
Protein Ontology PR:000012453 programmed cell death protein 2
References
(Earliest) J:23943 Vaux DL, et al., Cloning of mouse RP-8 cDNA and its expression during apoptosis of lymphoid and myeloid cells. DNA Cell Biol. 1995 Mar;14(3):189-93
(Latest) J:213699 Granier CJ, et al., Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest. Biol Open. 2014;3(9):821-31
All references(35)
Other
accession IDs
MGD-MRK-26081, MGI:2146889

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory