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Ptx3
Gene Detail
 Symbol
Name
ID
Ptx3
pentraxin related gene
MGI:104641
Synonyms pentraxin 3, TSG-14
Feature Type protein coding gene
Genetic Map
Chromosome 3
30.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:66219910-66225805 bp, + strand
From VEGA annotation of GRCm38

  5896 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7500  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Ptx3

Human
homologs
Human Homolog PTX3, pentraxin 3, long
NCBI Gene ID 5806
neXtProt AC  NX_P26022
Human Synonyms  TNFAIP5, TSG-14
Human Chr (Location)  3q25; chr3:157436791-157443628 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice display female subfertility due to abnormalities of the cumulus oophorus and are susceptible to invasive pulmonary aspergillosis associated with defective recognition of conidia by alveolar macrophages and dendritic cells and impaired induction of adaptive type 2 responses.
 
Interactions
Ptx3 interacts with 141 markers (Mir16-1, Mir16-2, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process innate immune response, negative regulation of exo-alpha-sialidase activity, ...
Component extracellular region, extracellular space
Function (1->3)-beta-D-glucan binding, complement component C1q binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) Genomic(3) cDNA(6) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000043511 (Evidence)
Ensembl Gene ModelENSMUSG00000027832 (Evidence)
Entrez Gene19288 (Evidence)
DFCITC1582385, TC1604200
DoTSDT.521720, DT.94123460, DT.94123467
NIA Mouse Gene IndexU003302
Consensus CDS ProjectCCDS17392.1
International Mouse Knockout Project StatusPtx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043511 VEGA Gene Model | MGI Sequence Detail 5896 C57BL/6J ±  kb
transcript OTTMUST00000114114 VEGA | MGI Sequence Detail 1898 Not Applicable 
polypeptide OTTMUSP00000063684 VEGA | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001759 Pentaxin
Protein Ontology PR:000013490 pentraxin-related protein PTX3
References (Earliest) J:29540 Altmeyer A, et al., Promoter structure and transcriptional activation of the murine TSG-14 gene encoding a tumor necrosis factor/interleukin-1-inducible pentraxin protein. J Biol Chem. 1995 Oct 27;270(43):25584-90
(Latest) J:209948 Jaillon S, et al., The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection. Immunity. 2014 Apr 17;40(4):621-32
All references(55)
Other
accession IDs
MGD-MRK-26079, MGI:2139768

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory