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Ptx3
Gene Detail
Symbol

Name
ID
Ptx3
pentraxin related gene
MGI:104641
Synonyms
pentraxin 3, TSG-14
Feature Type
protein coding gene
Genetic Map
Chromosome 3
30.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:66219910-66225805 bp, + strand
From VEGA annotation of GRCm38

  5896 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7500  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PTX3
Gene Tree: Ptx3

Human
homologs
PTX3, pentraxin 3, long
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5806
neXtProt AC: NX_P26022

Human Synonyms: TNFAIP5, TSG-14

Human Chr (Location): 3q25; chr3:157436791-157443628 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice display female subfertility due to abnormalities of the cumulus oophorus and are susceptible to invasive pulmonary aspergillosis associated with defective recognition of conidia by alveolar macrophages and dendritic cells and impaired induction of adaptive type 2 responses.
 
Interactions
Ptx3 interacts with 141 markers (Mir16-1, Mir16-2, Mir23a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
cDNA source data(5)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ptx3    NEW 
Molecular
reagents
All nucleic(10) Genomic(3) cDNA(6) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000043511 (Evidence)
Ensembl Gene Model ENSMUSG00000027832 (Evidence)
Entrez Gene 19288 (Evidence)
DFCI TC1582385, TC1604200
DoTS DT.521720, DT.94123460, DT.94123467
NIA Mouse Gene Index U003302
Consensus CDS Project CCDS17392.1
International Mouse Phenotyping Consortium Status Ptx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043511 VEGA Gene Model | MGI Sequence Detail 5896 C57BL/6J ±  kb
transcript OTTMUST00000114114 VEGA | MGI Sequence Detail 1898 Not Applicable 
polypeptide OTTMUSP00000063684 VEGA | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001759 Pentaxin
Protein Ontology PR:000013490 pentraxin-related protein PTX3
References
(Earliest) J:29540 Altmeyer A, et al., Promoter structure and transcriptional activation of the murine TSG-14 gene encoding a tumor necrosis factor/interleukin-1-inducible pentraxin protein. J Biol Chem. 1995 Oct 27;270(43):25584-90
(Latest) J:219871 Bonavita E, et al., PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer. Cell. 2015 Feb 12;160(4):700-14
All references(57)
Other
accession IDs
MGD-MRK-26079, MGI:2139768

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory