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Tff3 Gene Detail
Summary
  • Symbol
    Tff3
  • Name
    trefoil factor 3, intestinal
  • Synonyms
    ITF, mITF
  • Feature Type
    protein coding gene
  • IDs
    MGI:104638
    NCBI Gene: 21786
  • Gene Overview
    MyGene.info: TFF3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:31125306-31129646 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4341 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 15.80 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    TFF3, trefoil factor 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TFF3, trefoil factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ITF, P1B, TFI
  • Links
    NCBI Gene ID: 7033
    neXtProt AC: NX_Q07654
    UniProt: Q07654

  • Chr Location
    21q22.3; chr21:42311667-42315596 (-)  GRCh38.p7

Human Diseases
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  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired intestinal mucosal healing and death from colitis after administration of dextran sulfate sodium. Mice show poor epithelial regeneration after injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020099 VEGA Gene Model | MGI Sequence Detail 4341 C57BL/6J ±  kb
    transcript OTTMUST00000047795 VEGA | MGI Sequence Detail 493 Not Applicable  
    polypeptide OTTMUSP00000021729 VEGA | MGI Sequence Detail 81 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      83 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR017994 P-type trefoil, chordata
      IPR017957 P-type trefoil, conserved site
      IPR000519 P-type trefoil domain
    Molecular
    Reagents
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    • All nucleic 93
      Genomic 6
      cDNA 82
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-26075
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 26
      Diseases 3
      Gene Ontology 5
      Phenotypes 22
    • Earliest
      J:25263 Mashimo H, et al., Structure and expression of murine intestinal trefoil factor: high evolutionary conservation and postnatal expression. Biochem Biophys Res Commun. 1995 May 5;210(1):31-7
    • Latest
      J:257058 Liu C, et al., Triplications of human chromosome 21 orthologous regions in mice result in expansion of megakaryocyte-erythroid progenitors and reduction of granulocyte-macrophage progenitors. Oncotarget. 2018 Jan 12;9(4):4773-4786

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory