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Wars Gene Detail
Summary
  • Symbol
    Wars
  • Name
    tryptophanyl-tRNA synthetase
  • Feature Type
    protein coding gene
  • IDs
    MGI:104630
    NCBI Gene: 22375
  • Gene Overview
    MyGene.info: WARS
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:108860030-108894174 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 59.66 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    314 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104630
protein coding gene Chr12:108860030-108894174 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020111
protein coding gene Chr12:111020753-111055813 (-)
A/J MGP_AJ_G0020065
protein coding gene Chr12:106797600-106833660 (-)
AKR/J MGP_AKRJ_G0020041
protein coding gene Chr12:109895012-109931005 (-)
BALB/cJ MGP_BALBcJ_G0020051
protein coding gene Chr12:107220676-107254636 (-)
C3H/HeJ MGP_C3HHeJ_G0019853
protein coding gene Chr12:110343796-110378969 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020496
protein coding gene Chr12:114435691-114470339 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018108
protein coding gene Chr12:103315367-103355454 (-)
CAST/EiJ MGP_CASTEiJ_G0019395
protein coding gene Chr12:105288087-105323246 (-)
CBA/J MGP_CBAJ_G0019820
protein coding gene Chr12:119000617-119034686 (-)
DBA/2J MGP_DBA2J_G0019937
protein coding gene Chr12:106335048-106370359 (-)
FVB/NJ MGP_FVBNJ_G0019922
protein coding gene Chr12:105121648-105161144 (-)
LP/J MGP_LPJ_G0020012
protein coding gene Chr12:110883698-110919092 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019960
protein coding gene Chr12:122139405-122174448 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020525
protein coding gene Chr12:109380417-109415346 (-)
PWK/PhJ MGP_PWKPhJ_G0019154
protein coding gene Chr12:100957422-100992262 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018958
protein coding gene Chr12:103586456-103620423 (-)
WSB/EiJ MGP_WSBEiJ_G0019452
protein coding gene Chr12:110318651-110353472 (-)



Homology
more
  • Human Ortholog
    WARS, tryptophanyl-tRNA synthetase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WARS, tryptophanyl-tRNA synthetase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GAMMA-2, HMN9, IFI53, IFP53
  • Links
    NCBI Gene ID: 7453
    neXtProt AC: NX_P23381
    UniProt: P23381

  • Chr Location
    14q32.2; chr14:100333788-100376343 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22375 NCBI Gene Model | MGI Sequence Detail 34145 C57BL/6J ±  kb
    transcript NM_001164314 RefSeq | MGI Sequence Detail 2831 C57BL/6  
    polypeptide P32921 UniProt | EBI | MGI Sequence Detail 481 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 214
      cDNA 212
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-26067
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:20958 Pajot B, et al., An alternative splicing modifies the C-terminal end of tryptophanyl-tRNA synthetase in murine embryonic stem cells. J Mol Biol. 1994 Sep 30;242(4):599-603
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory