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Ccr3
Gene Detail
 Symbol
Name
ID
Ccr3
chemokine (C-C motif) receptor 3
MGI:104616
Synonyms CC-CKR3, CKR3, Cmkbr3, MIP-1 alphaRL2
Feature Type protein coding gene
Genetic Map
Chromosome 9
75.05 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:124021971-124031689 bp, + strand
From NCBI annotation of GRCm38

  9719 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20436  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: chemokine receptor
Gene Tree: Ccr3

Human
homologs
Human Homolog CCR3, chemokine (C-C motif) receptor 3
NCBI Gene ID 1232
neXtProt AC  NX_P51677
Human Synonyms  CC-CKR-3, CD193, CKR3, CMKBR3
Human Chr (Location)  3p21.3; chr3:46242381-46266706 (+)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Homozygous mutation of this gene results in impaired eosinophil trafficking to the lungs and small intestine, and in increased bronchorestriction following methacholine challenge.
 
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process angioblast cell migration, chemokine-mediated signaling pathway, ...
Component endosome, extracellular space, ...
Function C-C chemokine receptor activity, chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (29)    Tissues (20)    Images (3)
Theiler Stages: 13, 20, 23
Assay TypeResults
RNA in situ 24
RNase protection 5
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(13) Genomic(2) cDNA(9) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000035448 (Evidence)
Entrez Gene12771 (Evidence)
UniGene57050
DFCITC1589660, TC1599376
DoTSDT.101722979
NIA Mouse Gene IndexU011203
Consensus CDS ProjectCCDS23668.1
International Mouse Knockout Project StatusCcr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12771 NCBI Gene Model | MGI Sequence Detail 9719 C57BL/6J ±  kb
transcript NM_009914 RefSeq | MGI Sequence Detail 3273 C57BL/6 
polypeptide P51678 UniProt | EBI | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002238 CC chemokine receptor 3
InterPro IPR000355 Chemokine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001255 chemokine receptor CCR3
Graphical View of Protein Domain Structure
References (Earliest) J:27219 Gao JL, et al., Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor. J Biol Chem. 1995 Jul 21;270(29):17494-501
(Latest) J:201014 Sturm EM, et al., Chemotaxis of bone marrow derived eosinophils in vivo: a novel method to explore receptor-dependent trafficking in the mouse. Eur J Immunol. 2013 Aug;43(8):2217-28
All references(54)
Other
accession IDs
MGD-MRK-26053

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory