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Ccr3 Gene Detail
Summary
  • Symbol
    Ccr3
  • Name
    chemokine (C-C motif) receptor 3
  • Synonyms
    CC-CKR3, CKR3, Cmkbr3, MIP-1 alphaRL2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104616
    NCBI Gene: 12771
  • Gene Overview
    MyGene.info: CCR3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:124021972-124031689 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9718 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 75.05 cM, cytoband F
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CCR3, C-C motif chemokine receptor 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CCR3, C-C motif chemokine receptor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CC-CKR-3, CD193, CKR3, CMKBR3
  • Links
    NCBI Gene ID: 1232
    neXtProt AC: NX_P51677
    UniProt: P51677

  • Chr Location
    3p21.31; chr3:46210699-46266706 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired eosinophil trafficking to the lungs and small intestine, and in increased bronchorestriction following methacholine challenge.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035448 Ensembl Gene Model | MGI Sequence Detail 9718 C57BL/6J ±  kb
    transcript ENSMUST00000039171 Ensembl | MGI Sequence Detail 3272 Not Applicable  
    polypeptide ENSMUSP00000039107 Ensembl | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      162 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 2
      cDNA 9
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-26053
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:27219 Gao JL, et al., Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor. J Biol Chem. 1995 Jul 21;270(29):17494-501
    • Latest
      J:252631 Toyoda H, et al., Narcolepsy susceptibility gene CCR3 modulates sleep-wake patterns in mice. PLoS One. 2017;12(11):e0187888

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory