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Ccr3
Gene Detail
Symbol

Name
ID
Ccr3
chemokine (C-C motif) receptor 3
MGI:104616
Synonyms
CC-CKR3, CKR3, Cmkbr3, MIP-1 alphaRL2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
75.05 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:124021971-124031689 bp, + strand
From Ensembl annotation of GRCm38

  9719 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20436  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CCR3
Protein SuperFamily: chemokine receptor
Gene Tree: Ccr3

Human
homologs
CCR3, chemokine (C-C motif) receptor 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1232
neXtProt AC: NX_P51677

Human Synonyms: CC-CKR-3, CD193, CKR3, CMKBR3

Human Chr (Location): 3p21.3; chr3:46210695-46266706 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in impaired eosinophil trafficking to the lungs and small intestine, and in increased bronchorestriction following methacholine challenge.
 
Interactions
Ccr3 interacts with 264 markers (Mir7b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process angioblast cell migration, chemokine-mediated signaling pathway, ...
Component endosome, extracellular space, ...
Function C-C chemokine receptor activity, chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (29)    Tissues (20)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
RNase protection 5
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ccr3    NEW 
Molecular
reagents
All nucleic(13) Genomic(2) cDNA(9) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000035448 (Evidence)
Entrez Gene 12771 (Evidence)
UniGene 57050
DFCI TC1599376, TC1589660
DoTS DT.101722979
NIA Mouse Gene Index U011203
Consensus CDS Project CCDS23668.1
International Mouse Phenotyping Consortium Status Ccr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035448 Ensembl Gene Model | MGI Sequence Detail 9719 C57BL/6J ±  kb
transcript ENSMUST00000039171 Ensembl | MGI Sequence Detail 3273 Not Applicable 
polypeptide ENSMUSP00000039107 Ensembl | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002238 CC chemokine receptor 3
InterPro IPR000355 Chemokine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001255 C-C chemokine receptor type 3
References
(Earliest) J:27219 Gao JL, et al., Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor. J Biol Chem. 1995 Jul 21;270(29):17494-501
(Latest) J:219562 Ong S, et al., Natural killer cells limit cardiac inflammation and fibrosis by halting eosinophil infiltration. Am J Pathol. 2015 Mar;185(3):847-61
All references(55)
Other
accession IDs
MGD-MRK-26053

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory