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Ccr3 Gene Detail
Summary
  • Symbol
    Ccr3
  • Name
    chemokine (C-C motif) receptor 3
  • Synonyms
    CC-CKR3, CKR3, Cmkbr3, MIP-1 alphaRL2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104616
    NCBI Gene: 12771
  • Gene Overview
    MyGene.info: CCR3
Location & Maps
more
  • Sequence Map
    Chr9:124021971-124031689 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9719 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 75.05 cM, cytoband F
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CCR3, C-C motif chemokine receptor 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CCR3, C-C motif chemokine receptor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CC-CKR-3, CD193, CKR3, CMKBR3
  • Links
    NCBI Gene ID: 1232
    neXtProt AC: NX_P51677

  • Chr Location
    3p21.3; chr3:46210695-46266706 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired eosinophil trafficking to the lungs and small intestine, and in increased bronchorestriction following methacholine challenge.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035448 Ensembl Gene Model | MGI Sequence Detail 9719 C57BL/6J ±  kb
transcript ENSMUST00000039171 Ensembl | MGI Sequence Detail 3273 Not Applicable  
polypeptide ENSMUSP00000039107 Ensembl | MGI Sequence Detail 359 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    162 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001255 C-C chemokine receptor type 3
  • InterPro Domains
    IPR002238 CC chemokine receptor 3
    IPR000355 Chemokine receptor family
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 13
    Genomic 2
    cDNA 9
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-26053
References
more
  • Summaries
    All 53
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 20
  • Earliest
    J:27219 Gao JL, et al., Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor. J Biol Chem. 1995 Jul 21;270(29):17494-501
  • Latest
    J:219562 Ong S, et al., Natural killer cells limit cardiac inflammation and fibrosis by halting eosinophil infiltration. Am J Pathol. 2015 Mar;185(3):847-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory