Ccr3
Gene Detail

Symbol Name ID

Ccr3 chemokine (C-C motif) receptor 3 MGI:104616

Synonyms

CC-CKR3, CKR3, Cmkbr3, MIP-1 alphaRL2

Feature Type

protein coding gene

Genetic Map

Chromosome 9

75.05 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr9:124021971-124031689 bp, + strand From NCBI annotation of GRCm38   9719 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20436  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: chemokine receptor
Gene Tree: Ccr3

Human homologs

Human Homolog		CCR3, chemokine (C-C motif) receptor 3
NCBI Gene ID		1232
neXtProt AC		NX_P51677
Human Synonyms		CC-CKR-3, CD193, CKR3, CMKBR3
Human Chr (Location)		3p21.3; chr3:46283872-46308197 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous mutation of this gene results in impaired eosinophil trafficking to the lungs and small intestine, and in increased bronchorestriction following methacholine challenge.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	angioblast cell migration, chemokine-mediated signaling pathway, ...
Component	endosome, extracellular space, ...
Function	C-C chemokine binding, C-C chemokine receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (29)    Tissues (20)    Images (3)
Theiler Stages: 13, 20, 23

Assay Type	Results
RNA in situ	24
RNase protection	5

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) Genomic(2) cDNA(9) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000035448 (Evidence)
Entrez Gene	12771 (Evidence)
UniGene	57050
DFCI	TC1589660, TC1599376
DoTS	DT.101722979
NIA Mouse Gene Index	U011203
Consensus CDS Project	CCDS23668.1
International Mouse Knockout Project Status	Ccr3

Sequences

Length	Strain/Species
genomic	12771	NCBI Gene Model | MGI Sequence Detail	9719	C57BL/6J
transcript	NM_009914	RefSeq | MGI Sequence Detail	3273	C57BL/6
polypeptide	P51678	UniProt | EBI | MGI Sequence Detail	359	Not Applicable

All sequences(21) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(72 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002238	CC chemokine receptor, type 3
InterPro	IPR000355	Chemokine receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001255	chemokine receptor CCR3

Graphical View of Protein Domain Structure

References

(Earliest) J:27219 Gao JL, et al., Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor. J Biol Chem. 1995 Jul 21;270(29):17494-501
(Latest) J:189562 Chang LY, et al., The indispensable role of CCR5 for in vivo suppressor function of tumor-derived CD103+ effector/memory regulatory T cells. J Immunol. 2012 Jul 15;189(2):567-74
All references(53)

Other accession IDs

MGD-MRK-26053