Tnnt2
Gene Detail

Symbol Name ID

Tnnt2 troponin T2, cardiac MGI:104597

Synonyms

cardiac TnT, cTnT, Tnt

Feature Type

protein coding gene

Genetic Map

Chromosome 1

59.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:135836386-135852260 bp, + strand From Ensembl annotation of GRCm38   15875 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68050  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tnnt2

Human homologs

Human Homolog		TNNT2, troponin T type 2 (cardiac)
NCBI Gene ID		7139
neXtProt AC		NX_P45379
Human Synonyms		CMH2, CMPD2, cTnT, LVNC6, RCM3, TnTC
Human Chr (Location)		1q32; chr1:201328142-201346805 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human TNNT2

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a null allele exhibit embryonic lethality during and prior to organogenesis and abnormal heart development. Mice homozygous for an allele that lacks the lysine residue at position 210 exhibit dilated cardiomyopathy.

 
Human Diseases Modeled Using Mouse Tnnt2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	actin crosslink formation, ATP catabolic process, ...
Component	cytoplasm, myofibril, ...
Function	actin binding, ATPase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (58 records)
Data Summary: Results (136)    Tissues (36)    Images (44)
Theiler Stages: 8, 9, 10, 11, 12, 13, 14, 15, 17, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	9
RNA in situ	66
Northern blot	4
Western blot	3
RT-PCR	54

cDNA source data(121)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(129) Genomic(1) cDNA(122) Primer pair(5) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000026414 (Evidence)
Entrez Gene	21956 (Evidence)
UniGene	247470
DFCI	TC1574404, TC1587177, TC1615382, TC1633729, TC1638620
DoTS	DT.40166128, DT.91381260, DT.94358364, DT.99864904
NIA Mouse Gene Index	U000847
Consensus CDS Project	CCDS48375.1, CCDS48376.1, CCDS48377.1, CCDS48378.1
International Mouse Knockout Project Status	Tnnt2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000026414	Ensembl Gene Model | MGI Sequence Detail	15875	C57BL/6J
transcript	ENSMUST00000178204	Ensembl | MGI Sequence Detail	1172	Not Applicable
polypeptide	ENSMUSP00000137579	Ensembl | MGI Sequence Detail	302	Not Applicable

All sequences(73) RefSeq(18) UniProt(8)

Polymorphisms

SNPs(156 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001978	Troponin
Protein Ontology	PR:000016509	troponin T, cardiac muscle

References

(Earliest) J:20882 Chen Z, et al., Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Dev. 1994 Oct 1;8(19):2293-301
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(108)

Other accession IDs

MGD-MRK-26031