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Tnnt2
Gene Detail
 Symbol
Name
ID
Tnnt2
troponin T2, cardiac
MGI:104597
Synonyms cardiac TnT, cTnT, Tnt
Feature Type protein coding gene
Genetic Map
Chromosome 1
59.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:135836354-135852260 bp, + strand
From VEGA annotation of GRCm38

  15907 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68050  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tnnt2

Human
homologs
Human Homolog TNNT2, troponin T type 2 (cardiac)
NCBI Gene ID 7139
neXtProt AC  NX_P45379
Human Synonyms  CMD1D, CMH2, CMPD2, cTnT, LVNC6, RCM3, TnTC
Human Chr (Location)  1q32; chr1:201359008-201377760 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human TNNT2
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit embryonic lethality during and prior to organogenesis and abnormal heart development. Mice homozygous for an allele that lacks the lysine residue at position 210 exhibit dilated cardiomyopathy.
 
Human Diseases Modeled Using Mouse Tnnt2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Tnnt2 interacts with 32 markers (Mir103-1, Mir103-2, Mir107, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process actin crosslink formation, ATP catabolic process, ...
Component cytoplasm, myofibril, ...
Function actin binding, ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (65 records)
Data Summary: Results (136)    Tissues (38)    Images (44)
Theiler Stages: 8, 9, 10, 11, 12, 13, 14, 15, 17, 19, 20, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 9
RNA in situ 66
Northern blot 4
Western blot 3
RT-PCR 54
cDNA source data(121)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(129) Genomic(1) cDNA(122) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000049830 (Evidence)
Ensembl Gene ModelENSMUSG00000026414 (Evidence)
Entrez Gene21956 (Evidence)
UniGene247470
DFCITC1574404, TC1587177, TC1615382, TC1633729, TC1638620
DoTSDT.40166128, DT.91381260, DT.94358364, DT.99864904
NIA Mouse Gene IndexU000847
Consensus CDS ProjectCCDS48375.1, CCDS48376.1, CCDS48377.1, CCDS48378.1
International Mouse Knockout Project StatusTnnt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049830 VEGA Gene Model | MGI Sequence Detail 15907 C57BL/6J ±  kb
transcript OTTMUST00000126900 VEGA | MGI Sequence Detail 1200 Not Applicable 
polypeptide OTTMUSP00000068588 VEGA | MGI Sequence Detail 302 Not Applicable 

For the selected sequences
All sequences(115) RefSeq(44) UniProt(8)
Polymorphisms SNPs within 2kb(242 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001978 Troponin
Protein Ontology PR:000016509 troponin T, cardiac muscle
References (Earliest) J:20882 Chen Z, et al., Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Dev. 1994 Oct 1;8(19):2293-301
(Latest) J:207089 Liu Y, et al., CHD7 interacts with BMP R-SMADs to epigenetically regulate cardiogenesis in mice. Hum Mol Genet. 2014 Apr 15;23(8):2145-56
All references(120)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-26031

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory