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Tnnt2 Gene Detail
Summary
  • Symbol
    Tnnt2
  • Name
    troponin T2, cardiac
  • Synonyms
    cardiac TnT, cTnT, Tnt
  • Feature Type
    protein coding gene
  • IDs
    MGI:104597
    NCBI Gene: 21956
  • Gene Overview
    MyGene.info: TNNT2
Location & Maps
more
  • Sequence Map
    Chr1:135836354-135852260 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15907 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TNNT2, troponin T2, cardiac type
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TNNT2, troponin T2, cardiac type
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMD1D, CMH2, CMPD2, cTnT, LVNC6, RCM3, TnTC
  • Links
    NCBI Gene ID: 7139
    neXtProt AC: NX_P45379

  • Chr Location
    1q32; chr1:201359008-201377765 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 68050
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TNNT2
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Tnnt2 mouse models; 3 with human TNNT2 associations

Human Disease Mouse Models
       Cardiomyopathy, Dilated, 1D; CMD1D   OMIM: 601494 View 4 models
Cardiomyopathy, Familial Hypertrophic, 2; CMH2   OMIM: 115195 View 6 models
       Cardiomyopathy, Familial Restrictive, 3; RCM3   OMIM: 612422
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    10 with disease annotations
  • References
    11 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 9 alleles in 6 genetic backgrounds
    17 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    29
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    5
  • Transgenic
    21
  • Genomic Mutations
    3 involving Tnnt2
  • Incidental Mutations
Mice homozygous for a null allele exhibit embryonic lethality during and prior to organogenesis and abnormal heart development. Mice homozygous for an allele that lacks the lysine residue at position 210 exhibit dilated cardiomyopathy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049830 VEGA Gene Model | MGI Sequence Detail 15907 C57BL/6J ±  kb
transcript OTTMUST00000126900 VEGA | MGI Sequence Detail 1200 Not Applicable  
polypeptide OTTMUSP00000068588 VEGA | MGI Sequence Detail 302 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    245 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 129
    Genomic 1
    cDNA 122
    Primer pair 5
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-26031
References
more
  • Summaries
    All 142
    Developmental Gene Expression 87
    Diseases 11
    Gene Ontology 11
    Phenotypes 49
  • Earliest
    J:20882 Chen Z, et al., Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Dev. 1994 Oct 1;8(19):2293-301
  • Latest
    J:228946 Wei N, et al., SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing. Cell Rep. 2015 Nov 24;13(8):1647-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory