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Tnnt2 Gene Detail
Summary
  • Symbol
    Tnnt2
  • Name
    troponin T2, cardiac
  • Synonyms
    cardiac TnT, cTnT, Tnt
  • Feature Type
    protein coding gene
  • IDs
    MGI:104597
    NCBI Gene: 21956
  • Gene Overview
    MyGene.info: TNNT2
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:135836354-135852260 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 59.32 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    245 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104597
protein coding gene Chr1:135836315-135852268 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016530
protein coding gene Chr1:139624009-139639753 (+)
A/J MGP_AJ_G0016513
protein coding gene Chr1:134340455-134356165 (+)
AKR/J MGP_AKRJ_G0016478
protein coding gene Chr1:138337919-138353728 (+)
BALB/cJ MGP_BALBcJ_G0016473
protein coding gene Chr1:134660894-134677142 (+)
C3H/HeJ MGP_C3HHeJ_G0016299
protein coding gene Chr1:138435568-138452370 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016934
protein coding gene Chr1:144650228-144666073 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014645
protein coding gene Chr1:127445423-127461111 (+)
CAST/EiJ MGP_CASTEiJ_G0015879
protein coding gene Chr1:137517728-137533638 (+)
CBA/J MGP_CBAJ_G0016272
protein coding gene Chr1:149655159-149671014 (+)
DBA/2J MGP_DBA2J_G0016378
protein coding gene Chr1:133335629-133351430 (+)
FVB/NJ MGP_FVBNJ_G0016377
protein coding gene Chr1:131981666-131997581 (+)
LP/J MGP_LPJ_G0016449
protein coding gene Chr1:140855403-140871137 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016402
protein coding gene Chr1:155312491-155328394 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016970
protein coding gene Chr1:138105356-138123616 (+)
PWK/PhJ MGP_PWKPhJ_G0015665
protein coding gene Chr1:132373983-132389891 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015452
protein coding gene Chr1:137085075-137101460 (+)
WSB/EiJ MGP_WSBEiJ_G0015942
protein coding gene Chr1:138141499-138157723 (+)



Homology
more
  • Human Ortholog
    TNNT2, troponin T2, cardiac type
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TNNT2, troponin T2, cardiac type
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMD1D, CMH2, CMPD2, cTnT, LVNC6, RCM3, TnTC
  • Links
    NCBI Gene ID: 7139
    neXtProt AC: NX_P45379
    UniProt: P45379

  • Chr Location
    1q32.1; chr1:201359008-201377828 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68050
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TNNT2
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Tnnt2 mouse models; 3 with human TNNT2 associations

Human Disease Mouse Models
      
IDs
View 5 models
IDs
View 9 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    14 with disease annotations
  • References
    11 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    61 phenotypes from 12 alleles in 8 genetic backgrounds
    24 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality during and prior to organogenesis and abnormal heart development. Mice homozygous for an allele that lacks the lysine residue at position 210 exhibit dilated cardiomyopathy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026414 Ensembl Gene Model | MGI Sequence Detail 15907 C57BL/6J ±  kb
    transcript ENSMUST00000188028 Ensembl | MGI Sequence Detail 1200 Not Applicable  
    polypeptide ENSMUSP00000140941 Ensembl | MGI Sequence Detail 302 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 131
      Genomic 1
      cDNA 124
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-26031
    References
    more
    • Summaries
      All 241
      Developmental Gene Expression 136
      Diseases 11
      Gene Ontology 14
      Phenotypes 58
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:266263 Andersen P, et al., Precardiac organoids form two heart fields via Bmp/Wnt signaling. Nat Commun. 2018 Aug 7;9(1):3140

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory