Nbl1
Gene Detail

Symbol Name ID

Nbl1 neuroblastoma, suppression of tumorigenicity 1 MGI:104591

Synonyms

D4H1S1733E, DAN, Dana, NO3

Feature Type

protein coding gene

Genetic Map

Chromosome 4

70.57 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:139082284-139092993 bp, - strand From VEGA annotation of GRCm38   10710 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3924  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DAN protein
Gene Tree: Nbl1

Human homologs

Human Homolog		C1orf151-NBL1, C1orf151-NBL1 readthrough
NCBI Gene ID		100532736
neXtProt AC		NX_P41271
Human Chr (Location)		1p36.13; chr1:19923471-19984949 (+)  GRCh37.p10
Human Homolog		NBL1, neuroblastoma 1, DAN family BMP antagonist
NCBI Gene ID		4681
neXtProt AC		NX_P41271
Human Synonyms		D1S1733E, DAN, DAND1, NB, NO3
Human Chr (Location)		1p36.13; chr1:19969723-19984949 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for disruptions in this gene appear to have a normal nervous system, although one allele exhibits reduced sensitivity to pain during inflammation.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	determination of dorsal identity, negative regulation of monocyte chemotaxis, ...
Component	extracellular region
Function	BMP binding, morphogen activity, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (363)    Tissues (100)    Images (74)
Theiler Stages: 9, 11, 12, 13, 15, 17, 18, 20, 23, 28

Assay Type	Results
RNA in situ	344
RNase protection	19

cDNA source data(73)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(74) cDNA(74)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000009896 (Evidence)
Ensembl Gene Model	ENSMUSG00000041120 (Evidence)
Entrez Gene	17965 (Evidence)
UniGene	9404
DFCI	TC1577577
DoTS	DT.494461
NIA Mouse Gene Index	U025695
Consensus CDS Project	CCDS18839.1
International Mouse Knockout Project Status	Nbl1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009896	VEGA Gene Model | MGI Sequence Detail	10710	C57BL/6J
transcript	OTTMUST00000022949	VEGA | MGI Sequence Detail	1793	Not Applicable
polypeptide	OTTMUSP00000010476	VEGA | MGI Sequence Detail	178	Not Applicable

All sequences(26) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(57 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006207	Cystine knot, C-terminal
InterPro	IPR004133	DAN
InterPro	IPR016728	Neuroblastoma suppressor of tumorigenicity 1
Protein Ontology	PR:000011013	neuroblastoma suppressor of tumorigenicity 1

References

(Earliest) J:31883 Ozaki T, et al., Cloning of mouse DAN cDNA and its down-regulation in transformed cells. Jpn J Cancer Res. 1996 Jan;87(1):58-61
(Latest) J:187360 McKean DM, et al., Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly. Biol Open. 2012;1:874-883
All references(42)

Other accession IDs

MGD-MRK-26025, MGD-MRK-33709