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Actg2 Gene Detail
Summary
  • Symbol
    Actg2
  • Name
    actin, gamma 2, smooth muscle, enteric
  • Synonyms
    Act4, Act-4, ACTA3, SMGA
  • Feature Type
    protein coding gene
  • IDs
    MGI:104589
    NCBI Gene: 11468
  • Gene Overview
    MyGene.info: ACTG2
  • Alliance
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83512909-83536251 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    208 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104589
protein coding gene Chr6:83512905-83536265 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030933
protein coding gene Chr6:84518471-84542755 (-)
A/J MGP_AJ_G0030902
protein coding gene Chr6:81310473-81333331 (-)
AKR/J MGP_AKRJ_G0030830
protein coding gene Chr6:83661712-83685218 (-)
BALB/cJ MGP_BALBcJ_G0030912
protein coding gene Chr6:81333194-81355785 (-)
C3H/HeJ MGP_C3HHeJ_G0030798
protein coding gene Chr6:100704152-100728223 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031372
protein coding gene Chr6:86845432-86870785 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028558
protein coding gene Chr6:79662395-79684898 (-)
CAST/EiJ MGP_CASTEiJ_G0030021
protein coding gene Chr6:83681512-83704427 (-)
CBA/J MGP_CBAJ_G0030599
protein coding gene Chr6:90250646-90276365 (-)
DBA/2J MGP_DBA2J_G0030752
protein coding gene Chr6:80625388-80648390 (-)
FVB/NJ MGP_FVBNJ_G0030705
protein coding gene Chr6:79833902-79857123 (-)
LP/J MGP_LPJ_G0030831
protein coding gene Chr6:84527903-84554470 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030741
protein coding gene Chr6:94559112-94581812 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031396
protein coding gene Chr6:83473650-83496406 (-)
PWK/PhJ MGP_PWKPhJ_G0029736
protein coding gene Chr6:79531279-79554167 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029564
protein coding gene Chr6:82323497-82346387 (-)
WSB/EiJ MGP_WSBEiJ_G0030102
protein coding gene Chr6:83908654-83931379 (-)



Homology
more
  • Human Ortholog
    ACTG2, actin, gamma 2, smooth muscle, enteric
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACTG2, actin, gamma 2, smooth muscle, enteric
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACT, ACTA3, ACTE, ACTL3, ACTSG, VSCM
  • Links
    NCBI Gene ID: 72
    neXtProt AC: NX_P63267
    UniProt: P63267

  • Chr Location
    2p13.1; chr2:73892966-73919653 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 123845
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ACTG2
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ACTG2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from multigenic genotypes
    1 images
    7 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11468 NCBI Gene Model | MGI Sequence Detail 23343 C57BL/6J ±  kb
transcript NM_009610 RefSeq | MGI Sequence Detail 1341 C57BL/6  
polypeptide P63268 UniProt | EBI | MGI Sequence Detail 376 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 135
    Genomic 5
    cDNA 128
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1075, MGD-MRK-1079, MGD-MRK-26023
References
more
  • Summaries
    All 53
    Developmental Gene Expression 16
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:9892 Kim E, et al., Identification and developmental expression of a smooth-muscle gamma-actin in postmeiotic male germ cells of mice. Mol Cell Biol. 1989 May;9(5):1875-81
  • Latest
    J:245870 Cotton JL, et al., YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme. Dev Cell. 2017 Oct 09;43(1):35-47.e4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory