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Eps15l1 Gene Detail
Summary
  • Symbol
    Eps15l1
  • Name
    epidermal growth factor receptor pathway substrate 15-like 1
  • Synonyms
    9830147J04Rik, Eps15R, Eps15-rs
  • Feature Type
    protein coding gene
  • IDs
    MGI:104582
    NCBI Gene: 13859
  • Gene Overview
    MyGene.info: EPS15L1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:72340999-72421460 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 35.02 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    400 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104582
protein coding gene Chr8:72340990-72421541 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033780
protein coding gene Chr8:72824220-72912850 (-)
A/J MGP_AJ_G0033762
protein coding gene Chr8:69877256-69957338 (-)
AKR/J MGP_AKRJ_G0033689
protein coding gene Chr8:71941438-72024821 (-)
BALB/cJ MGP_BALBcJ_G0033756
protein coding gene Chr8:70011807-70095700 (-)
C3H/HeJ MGP_C3HHeJ_G0033465
protein coding gene Chr8:72574155-72658084 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034276
protein coding gene Chr8:75584094-75675999 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031217
protein coding gene Chr8:64396897-64480708 (-)
CAST/EiJ MGP_CASTEiJ_G0032794
protein coding gene Chr8:71926180-72008399 (-)
CBA/J MGP_CBAJ_G0033444
protein coding gene Chr8:78290213-78387263 (-)
DBA/2J MGP_DBA2J_G0033598
protein coding gene Chr8:69619780-69703556 (-)
FVB/NJ MGP_FVBNJ_G0033543
protein coding gene Chr8:68694967-68781035 (-)
LP/J MGP_LPJ_G0033687
protein coding gene Chr8:72912141-72998973 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033587
protein coding gene Chr8:80781093-80869661 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034293
protein coding gene Chr8:72011266-72098609 (-)
PWK/PhJ MGP_PWKPhJ_G0032500
protein coding gene Chr8:68878528-68961264 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032337
protein coding gene Chr8:70933171-71033487 (-)
WSB/EiJ MGP_WSBEiJ_G0032909
protein coding gene Chr8:72316077-72403221 (-)



Homology
more
  • Human Ortholog
    EPS15L1, epidermal growth factor receptor pathway substrate 15 like 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EPS15L1, epidermal growth factor receptor pathway substrate 15 like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPS15R
  • Links
    NCBI Gene ID: 58513
    neXtProt AC: NX_Q9UBC2
    UniProt: Q9UBC2

  • Chr Location
    19p13.11; chr19:16355244-16472012 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006276 Ensembl Gene Model | MGI Sequence Detail 80462 C57BL/6J ±  kb
transcript ENSMUST00000163643 Ensembl | MGI Sequence Detail 3129 Not Applicable  
polypeptide ENSMUSP00000129739 Ensembl | MGI Sequence Detail 907 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 120
    cDNA 120

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-26016, MGI:2142589, MGI:2444954
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:26202 Schumacher C, et al., The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R. J Biol Chem. 1995 Jun 23;270(25):15341-7
  • Latest
    J:190256 Teckchandani A, et al., The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis. Mol Biol Cell. 2012 Aug;23(15):2905-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory