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Eps15l1
Gene Detail
 Symbol
Name
ID
Eps15l1
epidermal growth factor receptor pathway substrate 15-like 1
MGI:104582
Synonyms 9830147J04Rik, Eps15R, Eps15-rs
Feature Type protein coding gene
Genetic Map
Chromosome 8
35.02 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:72341001-72421474 bp, - strand
From Ensembl annotation of GRCm38

  80474 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31881  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Eps15l1

Human
homologs
Human Homolog EPS15L1, epidermal growth factor receptor pathway substrate 15-like 1
NCBI Gene ID 58513
neXtProt AC  NX_Q9UBC2
Human Synonyms  EPS15R
Human Chr (Location)  19p13.11; chr19:16355244-16472012 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(102) : Gene trapped(100) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Eps15l1 interacts with 119 markers (Mir1a-1, Mir1a-2, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process endocytosis
Component clathrin coat of coated pit, coated pit, ...
Function calcium ion binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (54)    Tissues (45)    Images (10)
Theiler Stages: 20, 22
Assay TypeResults
Immunohistochemistry 54
cDNA source data(119)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(119) cDNA(119)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000006276 (Evidence)
Entrez Gene13859 (Evidence)
UniGene288894
DFCITC1574989, TC1583768, TC1594465, TC1624220, TC1653944
NIA Mouse Gene IndexU084109
Consensus CDS ProjectCCDS52597.1
International Mouse Knockout Project StatusEps15l1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006276 Ensembl Gene Model | MGI Sequence Detail 80474 C57BL/6J ±  kb
transcript ENSMUST00000163643 Ensembl | MGI Sequence Detail 3141 Not Applicable 
polypeptide ENSMUSP00000129739 Ensembl | MGI Sequence Detail 907 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(25) UniProt(1)
Polymorphisms SNPs within 2kb(399 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR000261 EPS15 homology (EH)
InterPro IPR003903 Ubiquitin interacting motif
Protein Ontology PR:000007146 epidermal growth factor receptor substrate 15-like 1
References (Earliest) J:26202 Schumacher C, et al., The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R. J Biol Chem. 1995 Jun 23;270(25):15341-7
(Latest) J:190256 Teckchandani A, et al., The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis. Mol Biol Cell. 2012 Aug;23(15):2905-16
All references(40)
Other
accession IDs
MGD-MRK-26016, MGI:2142589, MGI:2444954

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory