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Eps15l1 Gene Detail
Summary
  • Symbol
    Eps15l1
  • Name
    epidermal growth factor receptor pathway substrate 15-like 1
  • Synonyms
    9830147J04Rik, Eps15R, Eps15-rs
  • Feature Type
    protein coding gene
  • IDs
    MGI:104582
    NCBI Gene: 13859
  • Gene Overview
    MyGene.info: EPS15L1
Location & Maps
more
  • Sequence Map
    Chr8:72341001-72421474 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      80474 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 35.02 cM, cytoband C1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    EPS15L1, epidermal growth factor receptor pathway substrate 15 like 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EPS15L1, epidermal growth factor receptor pathway substrate 15 like 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EPS15R
  • Links
    NCBI Gene ID: 58513
    neXtProt AC: NX_Q9UBC2

  • Chr Location
    19p13.11; chr19:16355244-16472012 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    103
  • Chemically induced (other)
    1
  • Gene trapped
    100
  • Targeted
    2
  • Genomic Mutations
    1 involving Eps15l1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006276 Ensembl Gene Model | MGI Sequence Detail 80474 C57BL/6J ±  kb
transcript ENSMUST00000163643 Ensembl | MGI Sequence Detail 3141 Not Applicable  
polypeptide ENSMUSP00000129739 Ensembl | MGI Sequence Detail 907 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    400 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 119
    cDNA 119

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-26016, MGI:2142589, MGI:2444954
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:26202 Schumacher C, et al., The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R. J Biol Chem. 1995 Jun 23;270(25):15341-7
  • Latest
    J:190256 Teckchandani A, et al., The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis. Mol Biol Cell. 2012 Aug;23(15):2905-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory