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Il12rb1 Gene Detail
Summary
  • Symbol
    Il12rb1
  • Name
    interleukin 12 receptor, beta 1
  • Synonyms
    CD212, IL-12R[b]
  • Feature Type
    protein coding gene
  • IDs
    MGI:104579
    NCBI Gene: 16161
Location & Maps
more
  • Sequence Map
    Chr8:70808449-70821424 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12976 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.21 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    IL12RB1, interleukin 12 receptor subunit beta 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IL12RB1, interleukin 12 receptor subunit beta 1
    Orthology source: HomoloGene
  • Synonyms
    CD212, IL12RB, IL-12R-BETA1, IMD30
  • Links
    NCBI Gene ID: 3594
    neXtProt AC: NX_P42701

  • Chr Location
    19p13.1; chr19:18058995-18098986 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human IL12RB1 associations

Human Disease Mouse Models
       Immunodeficiency 30; IMD30   OMIM: 614891
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Targeted
    7
  • Genomic Mutations
    1 involving Il12rb1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit decreased serum IFN-gamma levels in response to recombinant IL-12 or LPS treatment, and failure of ConA-activated splenocytes to proliferate or secrete IFN-gamma in response to IL-12.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000791 Ensembl Gene Model | MGI Sequence Detail 12976 C57BL/6J ±  kb
transcript ENSMUST00000000808 Ensembl | MGI Sequence Detail 2873 Not Applicable  
polypeptide ENSMUSP00000000808 Ensembl | MGI Sequence Detail 738 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    97 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001367 interleukin-12 receptor subunit beta-1
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
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  • All nucleic 21
    Genomic 2
    cDNA 19

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-26013
References
more
  • Summaries
    All 75
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 43
  • Earliest
    J:29438 Chua AO, et al., Cloning and characterization of a mouse IL-12 receptor-beta component. J Immunol. 1995 Nov 1;155(9):4286-94
  • Latest
    J:211495 Jana M, et al., Interleukin-12 (IL-12), but not IL-23, induces the expression of IL-7 in microglia and macrophages: implications for multiple sclerosis. Immunology. 2014 Apr;141(4):549-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory