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Il12rb1
Gene Detail
 Symbol
Name
ID
Il12rb1
interleukin 12 receptor, beta 1
MGI:104579
Synonyms CD212, IL-12R[b]
Feature Type protein coding gene
Genetic Map
Chromosome 8
34.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:70808449-70821424 bp, + strand
From NCBI annotation of GRCm38

  12976 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4042  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: interleukin-12 receptor beta 1
Gene Tree: Il12rb1

Human
homologs
Human Homolog IL12RB1, interleukin 12 receptor, beta 1
NCBI Gene ID 3594
neXtProt AC  NX_P42701
Human Synonyms  CD212, IL12RB, IL-12R-BETA1
Human Chr (Location)  19p13.1; chr19:18059561-18086996 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human IL12RB1
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased serum IFN-gamma levels in response to recombinant IL-12 or LPS treatment, and failure of ConA-activated splenocytes to proliferate or secrete IFN-gamma in response to IL-12.
 
Interactions
Il12rb1 interacts with 82 markers (Mir23a, Mir23b, Mir30c-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cellular response to interferon-gamma, interleukin-12-mediated signaling pathway, ...
Component external side of plasma membrane, integral component of membrane, ...
Function cytokine binding, interleukin-12 receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (33)    Tissues (4)    Images (15)
Theiler Stages: 23
Assay TypeResults
RNA in situ 33
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(2) cDNA(19)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000000791 (Evidence)
Entrez Gene16161 (Evidence)
UniGene731
DFCITC1583408, TC1666039
DoTSDT.40172346, DT.528041, DT.55124512
NIA Mouse Gene IndexU009446
Consensus CDS ProjectCCDS22382.1
International Mouse Knockout Project StatusIl12rb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16161 NCBI Gene Model | MGI Sequence Detail 12976 C57BL/6J ±  kb
transcript NM_008353 RefSeq | MGI Sequence Detail 2873 C57BL/6 
polypeptide Q60837 UniProt | EBI | MGI Sequence Detail 738 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(14) UniProt(3)
Polymorphisms SNPs within 2kb(97 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000001367 interleukin-12 receptor subunit beta-1
Graphical View of Protein Domain Structure
References (Earliest) J:29438 Chua AO, et al., Cloning and characterization of a mouse IL-12 receptor-beta component. J Immunol. 1995 Nov 1;155(9):4286-94
(Latest) J:209908 Bielinska AU, et al., Distinct pathways of humoral and cellular immunity induced with the mucosal administration of a nanoemulsion adjuvant. J Immunol. 2014 Mar 15;192(6):2722-33
All references(78)
Other
accession IDs
MGD-MRK-26013

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory