Il12rb1
Gene Detail

Symbol Name ID

Il12rb1 interleukin 12 receptor, beta 1 MGI:104579

Synonyms

CD212, IL-12R[b]

Feature Type

protein coding gene

Genetic Map

Chromosome 8

34.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr8:70808449-70821424 bp, + strand From NCBI annotation of GRCm38   12976 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4042  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: interleukin-12 receptor beta 1
Gene Tree: Il12rb1

Human homologs

Human Homolog		IL12RB1, interleukin 12 receptor, beta 1
NCBI Gene ID		3594
neXtProt AC		NX_P42701
Human Synonyms		CD212, IL12RB, IL-12R-BETA1
Human Chr (Location)		19p13.1; chr19:18170371-18197697 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human IL12RB1

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele exhibit decreased serum IFN-gamma levels in response to recombinant IL-12 or LPS treatment, and failure of ConA-activated splenocytes to proliferate or secrete IFN-gamma in response to IL-12.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	cellular response to interferon-gamma, interleukin-12-mediated signaling pathway, ...
Component	external side of plasma membrane, integral to membrane, ...
Function	cytokine binding, interleukin-12 receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (33)    Tissues (4)    Images (15)
Theiler Stages: 23

Assay Type	Results
RNA in situ	33

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(2) cDNA(19)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000000791 (Evidence)
Entrez Gene	16161 (Evidence)
UniGene	731
DFCI	TC1583408, TC1666039
DoTS	DT.40172346, DT.528041, DT.55124512
NIA Mouse Gene Index	U009446
Consensus CDS Project	CCDS22382.1
International Mouse Knockout Project Status	Il12rb1

Sequences

Length	Strain/Species
genomic	16161	NCBI Gene Model | MGI Sequence Detail	12976	C57BL/6J
transcript	NM_008353	RefSeq | MGI Sequence Detail	2873	C57BL/6
polypeptide	Q60837	UniProt | EBI | MGI Sequence Detail	738	Not Applicable

All sequences(21) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(54 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
Protein Ontology	PR:000001367	interleukin-12 receptor subunit beta-1

Graphical View of Protein Domain Structure

References

(Earliest) J:29438 Chua AO, et al., Cloning and characterization of a mouse IL-12 receptor-beta component. J Immunol. 1995 Nov 1;155(9):4286-94
(Latest) J:192617 Richer MJ, et al., Pathogen-specific inflammatory milieux tune the antigen sensitivity of CD8(+) T cells by enhancing T cell receptor signaling. Immunity. 2013 Jan 24;38(1):140-52
All references(72)

Other accession IDs

MGD-MRK-26013