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Lct
Gene Detail
 Symbol
Name
ID
Lct
lactase
MGI:104576
Synonyms LOC226413, LPH, Lphl
Feature Type protein coding gene
Genetic Map
Chromosome 1
55.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr1:128284756-128328318 bp, - strand
From VEGA annotation of GRCm38

  43563 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:124204  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Gene Tree: Lct

Human
homologs
Human Homolog LCT, lactase
NCBI Gene ID 3938
neXtProt AC  NX_P09848
Human Synonyms  LAC, LPH, LPH1
Human Chr (Location)  2q21; chr2:135787845-135837180 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human LCT
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Lct interacts with 87 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process metabolic process, response to drug, ...
Component brush border
Function hydrolase activity, hydrolase activity, acting on glycosyl bonds, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000030320 (Evidence)
Ensembl Gene ModelENSMUSG00000026354 (Evidence)
Entrez Gene226413 (Evidence)
UniGene26930
DFCITC1646322
DoTSDT.101193991
NIA Mouse Gene IndexU021730
Consensus CDS ProjectCCDS35698.1
International Mouse Knockout Project StatusLct
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030320 VEGA Gene Model | MGI Sequence Detail 43563 C57BL/6J ±  kb
transcript OTTMUST00000075103 VEGA | MGI Sequence Detail 6174 Not Applicable 
polypeptide OTTMUSP00000039304 VEGA | MGI Sequence Detail 1931 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(261 from dbSNP Build 137)    SNPs within 2kb including multiple locations(263)
Protein-related
information
ResourceIDDescription
InterPro IPR013781 Glycoside hydrolase, catalytic domain
InterPro IPR001360 Glycoside hydrolase, family 1
InterPro IPR018120 Glycoside hydrolase, family 1, active site
InterPro IPR017853 Glycoside hydrolase, superfamily
Protein Ontology PR:000009734 lactase-phlorizin hydrolase
References (Earliest) J:29712 Uelmen PJ, et al., Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro. J Biol Chem. 1995 Nov 3;270(44):26192-201
(Latest) J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All references(42)
Other
accession IDs
MGD-MRK-26010, MGI:1261815, MGI:2684946

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory