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Lct Gene Detail
Summary
  • Symbol
    Lct
  • Name
    lactase
  • Synonyms
    LOC226413, LPH, Lphl
  • Feature Type
    protein coding gene
  • IDs
    MGI:104576
    NCBI Gene: 226413
Location & Maps
more
  • Sequence Map
    Chr1:128284756-128328318 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43563 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 55.80 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    LCT, lactase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LCT, lactase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LAC, LPH, LPH1
  • Links
    NCBI Gene ID: 3938
    neXtProt AC: NX_P09848
    UniProt: P09848

  • Chr Location
    2q21.3; chr2:135787840-135837200 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 124204
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;2 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LCT
  • Gene Tree
    Lct
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030320 VEGA Gene Model | MGI Sequence Detail 43563 C57BL/6J ±  kb
transcript OTTMUST00000075103 VEGA | MGI Sequence Detail 6174 Not Applicable  
polypeptide OTTMUSP00000039304 VEGA | MGI Sequence Detail 1931 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    253 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR001360 Glycoside hydrolase family 1
    IPR018120 Glycoside hydrolase family 1, active site
    IPR017853 Glycoside hydrolase superfamily
    IPR033132 Glycosyl hydrolases family 1, N-terminal conserved site
Molecular
Reagents
less
  • All nucleic 19
    cDNA 18
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-26010, MGI:1261815, MGI:2684946
References
more
  • Summaries
    All 44
    Developmental Gene Expression 8
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory