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Lct Gene Detail
Summary
  • Symbol
    Lct
  • Name
    lactase
  • Synonyms
    LOC226413, LPH, Lphl
  • Feature Type
    protein coding gene
  • IDs
    MGI:104576
    NCBI Gene: 226413
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:128284756-128328318 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 55.80 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    253 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104576
protein coding gene Chr1:128284756-128328318 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016428
protein coding gene Chr1:131523029-131569118 (-)
A/J MGP_AJ_G0016411
protein coding gene Chr1:126618262-126661207 (-)
AKR/J MGP_AKRJ_G0016376
protein coding gene Chr1:130366999-130411857 (-)
BALB/cJ MGP_BALBcJ_G0016371
protein coding gene Chr1:126993969-127038090 (-)
C3H/HeJ MGP_C3HHeJ_G0016197
protein coding gene Chr1:130531815-130575026 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016832
protein coding gene Chr1:136464726-136516937 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014545
protein coding gene Chr1:119975315-120019352 (-)
CAST/EiJ MGP_CASTEiJ_G0015778
protein coding gene Chr1:129507725-129560014 (-)
CBA/J MGP_CBAJ_G0016170
protein coding gene Chr1:141059356-141121753 (-)
DBA/2J MGP_DBA2J_G0016276
protein coding gene Chr1:125655448-125698556 (-)
FVB/NJ MGP_FVBNJ_G0016275
protein coding gene Chr1:124373372-124415917 (-)
LP/J MGP_LPJ_G0016347
protein coding gene Chr1:132870895-132916822 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016300
protein coding gene Chr1:146916433-146965959 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016868
protein coding gene Chr1:130138276-130191149 (-)
PWK/PhJ MGP_PWKPhJ_G0015564
protein coding gene Chr1:124626025-124675915 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015352
protein coding gene Chr1:129097169-129141758 (-)
WSB/EiJ MGP_WSBEiJ_G0015840
protein coding gene Chr1:130097537-130149098 (-)



Homology
more
  • Human Ortholog
    LCT, lactase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LCT, lactase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LAC, LPH, LPH1
  • Links
    NCBI Gene ID: 3938
    neXtProt AC: NX_P09848
    UniProt: P09848

  • Chr Location
    2q21.3; chr2:135787840-135837200 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 124204
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;2 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LCT
  • Gene Tree
    Lct
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 226413 NCBI Gene Model | MGI Sequence Detail 43563 C57BL/6J ±  kb
transcript NM_001081078 RefSeq | MGI Sequence Detail 6174 C57BL/6  
polypeptide NP_001074547 RefSeq | MGI Sequence Detail 1931 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR001360 Glycoside hydrolase family 1
    IPR018120 Glycoside hydrolase family 1, active site
    IPR017853 Glycoside hydrolase superfamily
    IPR033132 Glycosyl hydrolases family 1, N-terminal conserved site
Molecular
Reagents
less
  • All nucleic 20
    cDNA 19
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-26010, MGI:1261815, MGI:2684946
References
more
  • Summaries
    All 47
    Developmental Gene Expression 9
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:263836 Srivillibhuthur M, et al., TFAM is required for maturation of the fetal and adult intestinal epithelium. Dev Biol. 2018 Jul 15;439(2):92-101

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory