Lct
Gene Detail

Symbol Name ID

Lct lactase MGI:104576

Synonyms

LOC226413, LPH, Lphl

Feature Type

protein coding gene

Genetic Map

Chromosome 1

55.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr1:128284756-128328318 bp, - strand From VEGA annotation of GRCm38   43563 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:124204  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Lct

Human homologs

Human Homolog		LCT, lactase
NCBI Gene ID		3938
neXtProt AC		NX_P09848
Human Synonyms		LAC, LPH, LPH1
Human Chr (Location)		2q21; chr2:136545415-136594750 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LCT

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	metabolic process, response to drug, ...
Component	brush border
Function	hydrolase activity, hydrolase activity, acting on glycosyl bonds, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000030320 (Evidence)
Ensembl Gene Model	ENSMUSG00000026354 (Evidence)
Entrez Gene	226413 (Evidence)
UniGene	26930
DFCI	TC1646322
DoTS	DT.101193991
NIA Mouse Gene Index	U021730
Consensus CDS Project	CCDS35698.1
International Mouse Knockout Project Status	Lct

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030320	VEGA Gene Model | MGI Sequence Detail	43563	C57BL/6J
transcript	OTTMUST00000075103	VEGA | MGI Sequence Detail	6174	Not Applicable
polypeptide	OTTMUSP00000039304	VEGA | MGI Sequence Detail	1931	Not Applicable

All sequences(22) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(125 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013781	Glycoside hydrolase, catalytic domain
InterPro	IPR001360	Glycoside hydrolase, family 1
InterPro	IPR018120	Glycoside hydrolase, family 1, active site
InterPro	IPR017853	Glycoside hydrolase, superfamily
Protein Ontology	PR:000009734	lactase-phlorizin hydrolase

References

(Earliest) J:29712 Uelmen PJ, et al., Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro. J Biol Chem. 1995 Nov 3;270(44):26192-201
(Latest) J:190582 Bondow BJ, et al., E-cadherin is required for intestinal morphogenesis in the mouse. Dev Biol. 2012 Nov 1;371(1):1-12
All references(40)

Other accession IDs

MGD-MRK-26010, MGI:1261815, MGI:2684946