About   Help   FAQ
Lct
Gene Detail
Symbol

Name
ID
Lct
lactase
MGI:104576
Synonyms
LOC226413, LPH, Lphl
Feature Type
protein coding gene
Genetic Map
Chromosome 1
55.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr1:128284756-128328318 bp, - strand
From VEGA annotation of GRCm38

  43563 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:124204  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: LCT
Gene Tree: Lct

Human
homologs
LCT, lactase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3938
neXtProt AC: NX_P09848

Human Synonyms: LAC, LPH, LPH1

Human Chr (Location): 2q21; chr2:135787845-135837180 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LCT

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Lct interacts with 87 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process response to drug, response to ethanol, ...
Component brush border
Function lactase activity, transferase activity
External Resources: FuncBase
Expression
Literature Summary: (7 records)
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lct.2    NEW 
Molecular
reagents
All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000030320 (Evidence)
Ensembl Gene Model ENSMUSG00000026354 (Evidence)
Entrez Gene 226413 (Evidence)
UniGene 26930
DFCI TC1646322
DoTS DT.101193991
NIA Mouse Gene Index U021730
Consensus CDS Project CCDS35698.1
International Mouse Phenotyping Consortium Status Lct
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030320 VEGA Gene Model | MGI Sequence Detail 43563 C57BL/6J ±  kb
transcript OTTMUST00000075103 VEGA | MGI Sequence Detail 6174 Not Applicable 
polypeptide OTTMUSP00000039304 VEGA | MGI Sequence Detail 1931 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(261 from dbSNP Build 137)    SNPs within 2kb including multiple locations(263)
Protein-related
information
ResourceIDDescription
InterPro IPR013781 Glycoside hydrolase, catalytic domain
InterPro IPR001360 Glycoside hydrolase, family 1
InterPro IPR018120 Glycoside hydrolase, family 1, active site
InterPro IPR017853 Glycoside hydrolase, superfamily
Protein Ontology PR:000009734 lactase-phlorizin hydrolase
References
(Earliest) J:29712 Uelmen PJ, et al., Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro. J Biol Chem. 1995 Nov 3;270(44):26192-201
(Latest) J:214986 Walker EM, et al., GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development. Dev Biol. 2014 Aug 15;392(2):283-94
All references(40)
Other
accession IDs
MGD-MRK-26010, MGI:1261815, MGI:2684946

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory