Ptprj
Gene Detail

Symbol Name ID

Ptprj protein tyrosine phosphatase, receptor type, J MGI:104574

Synonyms

Byp, CD148, DEP-1, RPTPJ, Scc1, Scc-1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

50.19 cM, cytoband E1-2
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr2:90429754-90479170 bp, - strand From VEGA annotation of GRCm38   49417 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2130  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ptprj

Human homologs

Human Homolog		PTPRJ, protein tyrosine phosphatase, receptor type, J
NCBI Gene ID		5795
neXtProt AC		NX_Q12913
Human Synonyms		CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1
Human Chr (Location)		11p11.2; chr11:48002110-48192394 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PTPRJ

Alleles and phenotypes

All alleles(16) : Targeted(6) Gene trapped(8) QTL(2)
 

Mice homozygous for a null allele die in utero displaying severe growth retardation and cardiovascular defects. Homozygotes for a second null allele are viable, fertile and healthy with no spontaneous tumor formation. Homozygotes for a third null allele show sterility and a block B cell development.

 

Gene Ontology (GO) classifications

All GO classifications: (52 annotations)

Process	blood coagulation, dephosphorylation, ...
Component	cell-cell junction, cell junction, ...
Function	beta-catenin binding, delta-catenin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (31)    Tissues (6)    Images (9)
Theiler Stages: 21, 23, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	11
Western blot	9
RT-PCR	7

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(1) cDNA(24) Primer pair(1) Other(1)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000014165 (Evidence)
Ensembl Gene Model	ENSMUSG00000025314 (Evidence)
Entrez Gene	19271 (Evidence)
DFCI	TC1582319, TC1605128, TC1631017, TC1678952
DoTS	DT.110655944, DT.40185451
EC	3.1.3.48
Consensus CDS Project	CCDS50629.1, CCDS50630.1
International Mouse Knockout Project Status	Ptprj

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014165	VEGA Gene Model | MGI Sequence Detail	49417	C57BL/6J
transcript	OTTMUST00000033432	VEGA | MGI Sequence Detail	4197	Not Applicable
polypeptide	OTTMUSP00000014997	VEGA | MGI Sequence Detail	1299	Not Applicable

All sequences(65) RefSeq(4) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(484 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR000387	Protein-tyrosine/Dual specificity phosphatase
InterPro	IPR016130	Protein-tyrosine phosphatase, active site
InterPro	IPR000242	Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology	PR:000001924	receptor-type tyrosine-protein phosphatase eta

References

(Earliest) J:17866 Astigiano S, et al., Changes in gene expression following exposure of nulli-SCCl murine embryonal carcinoma cells to inducers of differentiation: characterization of a down-regulated mRNA. Differentiation. 1991 Feb;46(1):61-7
(Latest) J:182552 Giampietro C, et al., Overlapping and divergent signaling pathways of N-cadherin and VE-cadherin in endothelial cells. Blood. 2012 Mar 1;119(9):2159-70
All references(56)

Other accession IDs

MGD-MRK-14303, MGD-MRK-14304, MGD-MRK-26008, MGI:2138959, MGI:98238