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Ptprj
Gene Detail
Symbol

Name
ID
Ptprj
protein tyrosine phosphatase, receptor type, J
MGI:104574
Synonyms
Byp, CD148, DEP-1, RPTPJ, Scc1, Scc-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
50.19 cM, cytoband E1-2
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr2:90429754-90479170 bp, - strand
From VEGA annotation of GRCm38

  49417 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2130  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: PTPRJ
Gene Tree: Ptprj

Human
homologs
PTPRJ, protein tyrosine phosphatase, receptor type, J
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5795
neXtProt AC: NX_Q12913

Human Synonyms: CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1

Human Chr (Location): 11p11.2; chr11:47980558-48170842 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(8) QTL(2) Targeted(8)
Genomic Mutations involving Ptprj (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele die in utero displaying severe growth retardation and cardiovascular defects. Homozygotes for a second null allele are viable, fertile and healthy with no spontaneous tumor formation. Homozygotes for a third null allele show sterility and a block B cell development.
 
Interactions
Ptprj interacts with 454 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process blood coagulation, dephosphorylation, ...
Component cell-cell junction, cell junction, ...
Function beta-catenin binding, delta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (31)    Tissues (7)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 11
Western blot 9
RT-PCR 7
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN ptprja, ptprjb.1    NEW 
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(24) Primer pair(1) Other(1)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000014165 (Evidence)
Ensembl Gene Model ENSMUSG00000025314 (Evidence)
Entrez Gene 19271 (Evidence)
DFCI TC1582319, TC1605128, TC1631017, TC1678952
DoTS DT.110655944, DT.40185451
EC 3.1.3.48
Consensus CDS Project CCDS50629.1, CCDS50630.1
International Mouse Phenotyping Consortium Status Ptprj
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014165 VEGA Gene Model | MGI Sequence Detail 49417 C57BL/6J ±  kb
transcript OTTMUST00000033432 VEGA | MGI Sequence Detail 4197 Not Applicable 
polypeptide OTTMUSP00000014997 VEGA | MGI Sequence Detail 1299 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(12) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(700 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000001924 receptor-type tyrosine-protein phosphatase eta
References
(Earliest) J:17866 Astigiano S, et al., Changes in gene expression following exposure of nulli-SCCl murine embryonal carcinoma cells to inducers of differentiation: characterization of a down-regulated mRNA. Differentiation. 1991 Feb;46(1):61-7
(Latest) J:220971 Kruger J, et al., Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout mice. Mol Metab. 2015 Apr;4(4):325-36
All references(60)
Other
accession IDs
MGD-MRK-14303, MGD-MRK-14304, MGD-MRK-26008, MGI:2138959, MGI:98238

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory