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Ptprj
Gene Detail
 Symbol
Name
ID
Ptprj
protein tyrosine phosphatase, receptor type, J
MGI:104574
Synonyms Byp, CD148, DEP-1, RPTPJ, Scc1, Scc-1
Feature Type protein coding gene
Genetic Map
Chromosome 2
50.19 cM, cytoband E1-2
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr2:90429754-90479170 bp, - strand
From VEGA annotation of GRCm38

  49417 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2130  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ptprj

Human
homologs
Human Homolog PTPRJ, protein tyrosine phosphatase, receptor type, J
NCBI Gene ID 5795
neXtProt AC  NX_Q12913
Human Synonyms  CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1
Human Chr (Location)  11p11.2; chr11:47980558-48170842 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(8) QTL(2) Targeted(8)
Genomic Mutations involving Ptprj (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele die in utero displaying severe growth retardation and cardiovascular defects. Homozygotes for a second null allele are viable, fertile and healthy with no spontaneous tumor formation. Homozygotes for a third null allele show sterility and a block B cell development.
 
Interactions
Ptprj interacts with 455 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process blood coagulation, dephosphorylation, ...
Component cell-cell junction, cell junction, ...
Function beta-catenin binding, delta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (31)    Tissues (7)    Images (9)
Theiler Stages: 21, 23, 26, 27, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 11
Western blot 9
RT-PCR 7
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(24) Primer pair(1) Other(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000014165 (Evidence)
Ensembl Gene ModelENSMUSG00000025314 (Evidence)
Entrez Gene19271 (Evidence)
DFCITC1582319, TC1605128, TC1631017, TC1678952
DoTSDT.110655944, DT.40185451
EC3.1.3.48
Consensus CDS ProjectCCDS50629.1, CCDS50630.1
International Mouse Knockout Project StatusPtprj
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014165 VEGA Gene Model | MGI Sequence Detail 49417 C57BL/6J ±  kb
transcript OTTMUST00000033432 VEGA | MGI Sequence Detail 4197 Not Applicable 
polypeptide OTTMUSP00000014997 VEGA | MGI Sequence Detail 1299 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(12) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(700 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000001924 receptor-type tyrosine-protein phosphatase eta
References (Earliest) J:17866 Astigiano S, et al., Changes in gene expression following exposure of nulli-SCCl murine embryonal carcinoma cells to inducers of differentiation: characterization of a down-regulated mRNA. Differentiation. 1991 Feb;46(1):61-7
(Latest) J:201353 Katsumoto TR, et al., The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. J Clin Invest. 2013 May 1;123(5):2037-48
All references(59)
Other
accession IDs
MGD-MRK-14303, MGD-MRK-14304, MGD-MRK-26008, MGI:2138959, MGI:98238

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory