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Ptprj Gene Detail
Summary
  • Symbol
    Ptprj
  • Name
    protein tyrosine phosphatase, receptor type, J
  • Synonyms
    Byp, CD148, DEP-1, RPTPJ, Scc1, Scc-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104574
    NCBI Gene: 19271
  • Gene Overview
    MyGene.info: PTPRJ
Location & Maps
more
  • Sequence Map
    Chr2:90429754-90479170 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      49417 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 50.19 cM, cytoband E1-2
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    PTPRJ, protein tyrosine phosphatase, receptor type J
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTPRJ, protein tyrosine phosphatase, receptor type J
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1
  • Links
    NCBI Gene ID: 5795
    neXtProt AC: NX_Q12913

  • Chr Location
    11p11.2; chr11:47980558-48170842 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 5 alleles in 6 genetic backgrounds
    17 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • QTL
    2
  • Radiation induced
    1
  • Targeted
    8
  • Genomic Mutations
    4 involving Ptprj
  • Incidental Mutations
Mice homozygous for a null allele die in utero displaying severe growth retardation and cardiovascular defects. Homozygotes for a second null allele are viable, fertile and healthy with no spontaneous tumor formation. Homozygotes for a third null allele show sterility and a block B cell development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014165 VEGA Gene Model | MGI Sequence Detail 49417 C57BL/6J ±  kb
transcript OTTMUST00000033432 VEGA | MGI Sequence Detail 4197 Not Applicable  
polypeptide OTTMUSP00000014997 VEGA | MGI Sequence Detail 1299 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    684 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000001924 receptor-type tyrosine-protein phosphatase eta
  • EC
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR000242 PTP type protein phosphatase
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
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  • All nucleic 27
    Genomic 1
    cDNA 24
    Primer pair 1
    Other 1

    Microarray probesets 9
Other
Accession IDs
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MGD-MRK-14303, MGD-MRK-14304, MGD-MRK-26008, MGI:2138959, MGI:98238
References
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  • Summaries
    All 59
    Developmental Gene Expression 6
    Gene Ontology 10
    Phenotypes 21
  • Earliest
    J:17866 Astigiano S, et al., Changes in gene expression following exposure of nulli-SCCl murine embryonal carcinoma cells to inducers of differentiation: characterization of a down-regulated mRNA. Differentiation. 1991 Feb;46(1):61-7
  • Latest
    J:220971 Kruger J, et al., Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout mice. Mol Metab. 2015 Apr;4(4):325-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory